Absence of common polymorphisms of toll like receptor 4 (TLR4)

Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japan

Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Ichiro Hirata, Hiroshi Nakano

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Host genetic factors may play a key role in determining the long-term outcome of the Helicobacter pylori (H. pylori) infection. Toll-like receptor 4 (TLR4) mediated recognition of lipo-polysaccharide (LPS) is required for efficient recognition of gram-negative bacterial infections. The aim of this study is to investigate the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japanese population. The study was performed in 149 gastric cancer (GC) cases (mean age 64.0 ± 12.4, M:F = 109:40) and 94 patients without evidence of GC (mean age 64.1 ± 12.3, M:F = 65:25) as the control group. TLR4 Asp299Gly, Thr399Ile were determined by Polymerase chain reaction-length of polymorphisms (PCR-RFLP) in all the patients. Asp299Gly, Thr399Ile were not detected in all 243 patients enrolled in this study. In conclusion, our data suggest that TLR4 Asp299Gly, Thr399Ile are very rare in Japanese population and thus they may not be a important factor in determining the outcome of H. pylori infected individuals in Japan.

Original languageEnglish
Pages (from-to)62-65
Number of pages4
JournalJournal of Clinical Biochemistry and Nutrition
Volume40
Issue number1
DOIs
Publication statusPublished - 01-01-2007

Fingerprint

Toll-Like Receptor 4
Polymorphism
Japan
Helicobacter pylori
Stomach Neoplasms
Gram-Negative Bacterial Infections
Polymerase Chain Reaction
Polymerase chain reaction
Helicobacter Infections
Restriction Fragment Length Polymorphisms
Population
Polysaccharides
Control Groups

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

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title = "Absence of common polymorphisms of toll like receptor 4 (TLR4): Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japan",
abstract = "Host genetic factors may play a key role in determining the long-term outcome of the Helicobacter pylori (H. pylori) infection. Toll-like receptor 4 (TLR4) mediated recognition of lipo-polysaccharide (LPS) is required for efficient recognition of gram-negative bacterial infections. The aim of this study is to investigate the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japanese population. The study was performed in 149 gastric cancer (GC) cases (mean age 64.0 ± 12.4, M:F = 109:40) and 94 patients without evidence of GC (mean age 64.1 ± 12.3, M:F = 65:25) as the control group. TLR4 Asp299Gly, Thr399Ile were determined by Polymerase chain reaction-length of polymorphisms (PCR-RFLP) in all the patients. Asp299Gly, Thr399Ile were not detected in all 243 patients enrolled in this study. In conclusion, our data suggest that TLR4 Asp299Gly, Thr399Ile are very rare in Japanese population and thus they may not be a important factor in determining the outcome of H. pylori infected individuals in Japan.",
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Absence of common polymorphisms of toll like receptor 4 (TLR4) : Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japan. / Tahara, Tomomitsu; Arisawa, Tomiyasu; Shibata, Tomoyuki; Hirata, Ichiro; Nakano, Hiroshi.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 40, No. 1, 01.01.2007, p. 62-65.

Research output: Contribution to journalArticle

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