TY - JOUR
T1 - Absence of SHATI/Nat8l reduces social interaction in mice
AU - Furukawa-Hibi, Yoko
AU - Nitta, Atsumi
AU - Fukumitsu, Hidefumi
AU - Somiya, Hitomi
AU - Toriumi, Kazuya
AU - Furukawa, Shoei
AU - Nabeshima, Toshitaka
AU - Yamada, Kiyofumi
N1 - Funding Information:
Yoko Furukawa-Hibi is a research resident of the Japan Foundation for Aging and Health. This study was supported in part by a Comprehensive Research grant on Aging and Health from the Ministry of Health, Labor and Welfare of Japan ; the Global Center of Excellence program ‘Integrated Functional Molecular Medicine for Neuronal and Neoplastic Disorders’ from the Ministry of Education, Culture, Sports, Science and Technology of Japan ; a Grant-in-aid for Exploratory Research and Scientific Research from the JSPS (Kakenhi) ; a Smoking Research Foundation Grant for Biomedical Research; an Academic Frontier Project grant for Private Universities (2007–2011) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan; and Funding Program for Next Generation World-Leading Researchers (NEXT Program) .
PY - 2012/9/27
Y1 - 2012/9/27
N2 - We previously identified a novel molecule "Shati/Nat8l" from the nucleus accumbens of mice. However, the physiological roles of the SHATI protein are not clear. To investigate the effect of SHATI on the central nervous system and behavior, we studied knockout mice of this protein. We carried out various behavior tests using Shati-knockout mice. Shati-knockout mice did not differ from wild type mice in learning and memory. In the open field test, Shati-knockout mice did not differ from wild-type mice in time of stay in the outer, middle and center areas. On the other hand, Shati-knockout mice showed increases in rearing and grooming time in the open field test, and exploration time of novel objects. These results suggested that knockout of the Shati gene may increase exploration in specific circumstances. Interestingly, the Shati-knockout mice avoided social interaction with unfamiliar mice out of their home cage, although there was no difference in social interaction in their home cage compared with wild type mice. Lack of the Shati gene increased brain-derived neurotrophic factor (BDNF) mRNA in the prefrontal cortex and hippocampus, and decreased glial cell line-derived neurotrophic factor (GDNF) mRNA in the striatum and hippocampus, and lipopolysaccharides-induced TNF-α factor (LITAF) mRNA in the striatum. Since these factors play important roles in behavior, alteration of expression of these factors may be related to the induction of exploration and reduction of social interaction in Shati-knockout mice.
AB - We previously identified a novel molecule "Shati/Nat8l" from the nucleus accumbens of mice. However, the physiological roles of the SHATI protein are not clear. To investigate the effect of SHATI on the central nervous system and behavior, we studied knockout mice of this protein. We carried out various behavior tests using Shati-knockout mice. Shati-knockout mice did not differ from wild type mice in learning and memory. In the open field test, Shati-knockout mice did not differ from wild-type mice in time of stay in the outer, middle and center areas. On the other hand, Shati-knockout mice showed increases in rearing and grooming time in the open field test, and exploration time of novel objects. These results suggested that knockout of the Shati gene may increase exploration in specific circumstances. Interestingly, the Shati-knockout mice avoided social interaction with unfamiliar mice out of their home cage, although there was no difference in social interaction in their home cage compared with wild type mice. Lack of the Shati gene increased brain-derived neurotrophic factor (BDNF) mRNA in the prefrontal cortex and hippocampus, and decreased glial cell line-derived neurotrophic factor (GDNF) mRNA in the striatum and hippocampus, and lipopolysaccharides-induced TNF-α factor (LITAF) mRNA in the striatum. Since these factors play important roles in behavior, alteration of expression of these factors may be related to the induction of exploration and reduction of social interaction in Shati-knockout mice.
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U2 - 10.1016/j.neulet.2012.08.028
DO - 10.1016/j.neulet.2012.08.028
M3 - Article
C2 - 22940080
AN - SCOPUS:84865996636
SN - 0304-3940
VL - 526
SP - 79
EP - 84
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -