TY - JOUR
T1 - Acceleration of palatal wound healing in Smad3-deficient mice
AU - Jinno, K.
AU - Takahashi, T.
AU - Tsuchida, K.
AU - Tanaka, E.
AU - Moriyama, K.
PY - 2009/8
Y1 - 2009/8
N2 - Wound healing is a well-orchestrated complex process leading to the repair of injured tissues. It is suggested that transforming growth factor (TGF)-β/ Smad3 signaling is involved in wound healing. The purpose of this study was to investigate the role of TGF-β/Smad3 signaling in palatal wound healing in Smad3-deficient (Smad3-/-) mice. Histological examination showed that wound closure was accelerated by the proliferation of epithelium and dermal cells in Smad3-/- mice compared with wild-type (WT) mice. Macrophage/monocyte infiltration at wounded regions in Smad3-/- mice was decreased in parallel with the diminished production of TGF-β1, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α compared with WT mice. Fibrocytes, expressing hematopoietic surface marker and fibroblast products, were recruited and produced α-smooth-muscle actin in WT mice, but were not observed in Smad3-/- mice. These results suggest that TGF-β/Smad3 signaling may play an important role in the regulation of palatal wound healing.
AB - Wound healing is a well-orchestrated complex process leading to the repair of injured tissues. It is suggested that transforming growth factor (TGF)-β/ Smad3 signaling is involved in wound healing. The purpose of this study was to investigate the role of TGF-β/Smad3 signaling in palatal wound healing in Smad3-deficient (Smad3-/-) mice. Histological examination showed that wound closure was accelerated by the proliferation of epithelium and dermal cells in Smad3-/- mice compared with wild-type (WT) mice. Macrophage/monocyte infiltration at wounded regions in Smad3-/- mice was decreased in parallel with the diminished production of TGF-β1, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α compared with WT mice. Fibrocytes, expressing hematopoietic surface marker and fibroblast products, were recruited and produced α-smooth-muscle actin in WT mice, but were not observed in Smad3-/- mice. These results suggest that TGF-β/Smad3 signaling may play an important role in the regulation of palatal wound healing.
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U2 - 10.1177/0022034509341798
DO - 10.1177/0022034509341798
M3 - Article
C2 - 19734465
AN - SCOPUS:70349310420
SN - 0022-0345
VL - 88
SP - 757
EP - 761
JO - Journal of Dental Research
JF - Journal of Dental Research
IS - 8
ER -