Acceleration of Phagocytosis in Human Neutrophils Incubated with Gabexate Mesilate

K. Mikawa, H. Akamatsu, N. Maekawa, K. Nishina, H. Obara, Y. Niwa

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

It has recently been shown that gabexate mesilate inhibited human neutrophil functions including chemotaxis and reactive oxygen species production. In the present study, the effects of gabexate mesilate on phagocytosis by human neutrophils in vitro were investigated. Gabexate mesilate significantly enhanced neutrophil phagocytosis in a dose-dependent manner. This characteristic of gabexate mesilate may facilitate protection against infecting micro-organisms, although the inhibition of reactive oxygen species production by neutrophils may be a disadvantage for host-defense against infection.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalJournal of International Medical Research
Volume22
Issue number5
DOIs
Publication statusPublished - 09-1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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