Accumulation of bisphenol A in hemodialysis patients

Kazutaka Murakami, Atsushi Ohashi, Hideo Hori, Makoto Hibiya, Yumiko Shoji, Miyuki Kunisaki, Miho Akita, Akira Yagi, Kazuhiro Sugiyama, Sachiko Shimozato, Kazuhiro Ito, Hiroki Takahashi, Kazuo Takahashi, Kouichirou Yamamoto, Masami Kasugai, Nahoko Kawamura, Shigeru Nakai, Midori Hasegawa, Makoto Tomita, Kunihiro NabeshimaYoshiyuki Hiki, Satoshi Sugiyama

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Bisphenol A [BPA, 2,2-bis(4-hydoxyphenyl)propane], an industrial chemical used in the production of polycarbonate, epoxide resin, and polyarylate, is considered to be an endocrine-disrupting chemical. BPA may be present in some hollow-fiber dialyzers used in hemodialysis. In this study, we tested the amounts of BPA eluted from various hollow fibers. Furthermore, we measured the BPA concentration in the sera of 22 renal disease predialysis patients, as well as 15 patients who were receiving hemodialysis, to see if there is BPA accumulation in these patients. The elution test of BPA showed that a much larger amount of BPA was eluted from polysulfone (PS), and polyester- polymeralloy hollow fibers. Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association. In a crossover test between PS and cellulose (Ce) dialyzers, the predialysis serum BPA concentration of PS dialyzer users decreased after changing to a Ce dialyzer, and the serum BPA increased again after switching back to PS dialyzers. In patients who were using PS dialyzers, the BPA level significantly increased after a dialysis session. However, in the Ce dialyzer users, the BPA level decreased. Since accumulation of BPA could affect the endocrine or metabolic system of the human body, it is important to perform further investigations on dialysis patients.

Original languageEnglish
Pages (from-to)290-294
Number of pages5
JournalBlood Purification
Volume25
Issue number3
DOIs
Publication statusPublished - 01-07-2007

Fingerprint

Renal Dialysis
Cellulose
polycarbonate
Serum
Kidney
Dialysis
Endocrine Disruptors
Propane
Polyesters
Epoxy Compounds
Human Body
bisphenol A
polysulfone P 1700

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Murakami, K., Ohashi, A., Hori, H., Hibiya, M., Shoji, Y., Kunisaki, M., ... Sugiyama, S. (2007). Accumulation of bisphenol A in hemodialysis patients. Blood Purification, 25(3), 290-294. https://doi.org/10.1159/000104869
Murakami, Kazutaka ; Ohashi, Atsushi ; Hori, Hideo ; Hibiya, Makoto ; Shoji, Yumiko ; Kunisaki, Miyuki ; Akita, Miho ; Yagi, Akira ; Sugiyama, Kazuhiro ; Shimozato, Sachiko ; Ito, Kazuhiro ; Takahashi, Hiroki ; Takahashi, Kazuo ; Yamamoto, Kouichirou ; Kasugai, Masami ; Kawamura, Nahoko ; Nakai, Shigeru ; Hasegawa, Midori ; Tomita, Makoto ; Nabeshima, Kunihiro ; Hiki, Yoshiyuki ; Sugiyama, Satoshi. / Accumulation of bisphenol A in hemodialysis patients. In: Blood Purification. 2007 ; Vol. 25, No. 3. pp. 290-294.
@article{133037bfe33b479f9ef0d76bc652bc24,
title = "Accumulation of bisphenol A in hemodialysis patients",
abstract = "Bisphenol A [BPA, 2,2-bis(4-hydoxyphenyl)propane], an industrial chemical used in the production of polycarbonate, epoxide resin, and polyarylate, is considered to be an endocrine-disrupting chemical. BPA may be present in some hollow-fiber dialyzers used in hemodialysis. In this study, we tested the amounts of BPA eluted from various hollow fibers. Furthermore, we measured the BPA concentration in the sera of 22 renal disease predialysis patients, as well as 15 patients who were receiving hemodialysis, to see if there is BPA accumulation in these patients. The elution test of BPA showed that a much larger amount of BPA was eluted from polysulfone (PS), and polyester- polymeralloy hollow fibers. Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association. In a crossover test between PS and cellulose (Ce) dialyzers, the predialysis serum BPA concentration of PS dialyzer users decreased after changing to a Ce dialyzer, and the serum BPA increased again after switching back to PS dialyzers. In patients who were using PS dialyzers, the BPA level significantly increased after a dialysis session. However, in the Ce dialyzer users, the BPA level decreased. Since accumulation of BPA could affect the endocrine or metabolic system of the human body, it is important to perform further investigations on dialysis patients.",
author = "Kazutaka Murakami and Atsushi Ohashi and Hideo Hori and Makoto Hibiya and Yumiko Shoji and Miyuki Kunisaki and Miho Akita and Akira Yagi and Kazuhiro Sugiyama and Sachiko Shimozato and Kazuhiro Ito and Hiroki Takahashi and Kazuo Takahashi and Kouichirou Yamamoto and Masami Kasugai and Nahoko Kawamura and Shigeru Nakai and Midori Hasegawa and Makoto Tomita and Kunihiro Nabeshima and Yoshiyuki Hiki and Satoshi Sugiyama",
year = "2007",
month = "7",
day = "1",
doi = "10.1159/000104869",
language = "English",
volume = "25",
pages = "290--294",
journal = "Blood Purification",
issn = "0253-5068",
publisher = "S. Karger AG",
number = "3",

}

Murakami, K, Ohashi, A, Hori, H, Hibiya, M, Shoji, Y, Kunisaki, M, Akita, M, Yagi, A, Sugiyama, K, Shimozato, S, Ito, K, Takahashi, H, Takahashi, K, Yamamoto, K, Kasugai, M, Kawamura, N, Nakai, S, Hasegawa, M, Tomita, M, Nabeshima, K, Hiki, Y & Sugiyama, S 2007, 'Accumulation of bisphenol A in hemodialysis patients', Blood Purification, vol. 25, no. 3, pp. 290-294. https://doi.org/10.1159/000104869

Accumulation of bisphenol A in hemodialysis patients. / Murakami, Kazutaka; Ohashi, Atsushi; Hori, Hideo; Hibiya, Makoto; Shoji, Yumiko; Kunisaki, Miyuki; Akita, Miho; Yagi, Akira; Sugiyama, Kazuhiro; Shimozato, Sachiko; Ito, Kazuhiro; Takahashi, Hiroki; Takahashi, Kazuo; Yamamoto, Kouichirou; Kasugai, Masami; Kawamura, Nahoko; Nakai, Shigeru; Hasegawa, Midori; Tomita, Makoto; Nabeshima, Kunihiro; Hiki, Yoshiyuki; Sugiyama, Satoshi.

In: Blood Purification, Vol. 25, No. 3, 01.07.2007, p. 290-294.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Accumulation of bisphenol A in hemodialysis patients

AU - Murakami, Kazutaka

AU - Ohashi, Atsushi

AU - Hori, Hideo

AU - Hibiya, Makoto

AU - Shoji, Yumiko

AU - Kunisaki, Miyuki

AU - Akita, Miho

AU - Yagi, Akira

AU - Sugiyama, Kazuhiro

AU - Shimozato, Sachiko

AU - Ito, Kazuhiro

AU - Takahashi, Hiroki

AU - Takahashi, Kazuo

AU - Yamamoto, Kouichirou

AU - Kasugai, Masami

AU - Kawamura, Nahoko

AU - Nakai, Shigeru

AU - Hasegawa, Midori

AU - Tomita, Makoto

AU - Nabeshima, Kunihiro

AU - Hiki, Yoshiyuki

AU - Sugiyama, Satoshi

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Bisphenol A [BPA, 2,2-bis(4-hydoxyphenyl)propane], an industrial chemical used in the production of polycarbonate, epoxide resin, and polyarylate, is considered to be an endocrine-disrupting chemical. BPA may be present in some hollow-fiber dialyzers used in hemodialysis. In this study, we tested the amounts of BPA eluted from various hollow fibers. Furthermore, we measured the BPA concentration in the sera of 22 renal disease predialysis patients, as well as 15 patients who were receiving hemodialysis, to see if there is BPA accumulation in these patients. The elution test of BPA showed that a much larger amount of BPA was eluted from polysulfone (PS), and polyester- polymeralloy hollow fibers. Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association. In a crossover test between PS and cellulose (Ce) dialyzers, the predialysis serum BPA concentration of PS dialyzer users decreased after changing to a Ce dialyzer, and the serum BPA increased again after switching back to PS dialyzers. In patients who were using PS dialyzers, the BPA level significantly increased after a dialysis session. However, in the Ce dialyzer users, the BPA level decreased. Since accumulation of BPA could affect the endocrine or metabolic system of the human body, it is important to perform further investigations on dialysis patients.

AB - Bisphenol A [BPA, 2,2-bis(4-hydoxyphenyl)propane], an industrial chemical used in the production of polycarbonate, epoxide resin, and polyarylate, is considered to be an endocrine-disrupting chemical. BPA may be present in some hollow-fiber dialyzers used in hemodialysis. In this study, we tested the amounts of BPA eluted from various hollow fibers. Furthermore, we measured the BPA concentration in the sera of 22 renal disease predialysis patients, as well as 15 patients who were receiving hemodialysis, to see if there is BPA accumulation in these patients. The elution test of BPA showed that a much larger amount of BPA was eluted from polysulfone (PS), and polyester- polymeralloy hollow fibers. Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association. In a crossover test between PS and cellulose (Ce) dialyzers, the predialysis serum BPA concentration of PS dialyzer users decreased after changing to a Ce dialyzer, and the serum BPA increased again after switching back to PS dialyzers. In patients who were using PS dialyzers, the BPA level significantly increased after a dialysis session. However, in the Ce dialyzer users, the BPA level decreased. Since accumulation of BPA could affect the endocrine or metabolic system of the human body, it is important to perform further investigations on dialysis patients.

UR - http://www.scopus.com/inward/record.url?scp=34447519144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447519144&partnerID=8YFLogxK

U2 - 10.1159/000104869

DO - 10.1159/000104869

M3 - Article

C2 - 17622711

AN - SCOPUS:34447519144

VL - 25

SP - 290

EP - 294

JO - Blood Purification

JF - Blood Purification

SN - 0253-5068

IS - 3

ER -