Accumulation of bisphenol A in hemodialysis patients

Kazutaka Murakami, Atsushi Ohashi, Hideo Hori, Makoto Hibiya, Yumiko Shoji, Miyuki Kunisaki, Miho Akita, Akira Yagi, Kazuhiro Sugiyama, Sachiko Shimozato, Kazuhiro Ito, Hiroki Takahashi, Kazuo Takahashi, Kouichirou Yamamoto, Masami Kasugai, Nahoko Kawamura, Shigeru Nakai, Midori Hasegawa, Makoto Tomita, Kunihiro NabeshimaYoshiyuki Hiki, Satoshi Sugiyama

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Bisphenol A [BPA, 2,2-bis(4-hydoxyphenyl)propane], an industrial chemical used in the production of polycarbonate, epoxide resin, and polyarylate, is considered to be an endocrine-disrupting chemical. BPA may be present in some hollow-fiber dialyzers used in hemodialysis. In this study, we tested the amounts of BPA eluted from various hollow fibers. Furthermore, we measured the BPA concentration in the sera of 22 renal disease predialysis patients, as well as 15 patients who were receiving hemodialysis, to see if there is BPA accumulation in these patients. The elution test of BPA showed that a much larger amount of BPA was eluted from polysulfone (PS), and polyester- polymeralloy hollow fibers. Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association. In a crossover test between PS and cellulose (Ce) dialyzers, the predialysis serum BPA concentration of PS dialyzer users decreased after changing to a Ce dialyzer, and the serum BPA increased again after switching back to PS dialyzers. In patients who were using PS dialyzers, the BPA level significantly increased after a dialysis session. However, in the Ce dialyzer users, the BPA level decreased. Since accumulation of BPA could affect the endocrine or metabolic system of the human body, it is important to perform further investigations on dialysis patients.

Original languageEnglish
Pages (from-to)290-294
Number of pages5
JournalBlood Purification
Issue number3
Publication statusPublished - 07-2007

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology


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