Accuracy of 64-slice multidetector computed tomography for classification and quantitation of coronary plaque: Comparison with integrated backscatter intravascular ultrasound

Ken Harada, Tetsuya Amano, Tadayuki Uetani, Hidehito Funahashi, Kosuke Arai, Koji Okada, Akihiro Hirashiki, Mutsuharu Hayashi, Satoru Oshima, Hideki Ishii, Hideo Izawa, Tatsuaki Matsubara, Toyoaki Murohara

Research output: Contribution to journalArticle

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Abstract

Background: Noninvasive assessment of coronary plaque is important for coronary risk stratification. Whereas integrated backscatter intravascular ultrasound (IB-IVUS) has proven effective for analysis of the tissue components of coronary plaque, plaque assessment by 64-slice multidetector computed tomography (MDCT) has not been established. We therefore evaluated the accuracy of MDCT compared with IB-IVUS for identification of coronary plaque components and determination of plaque volume. Methods: Thirty-one sites in 17 coronary vessels (7 left anterior descending, 5 left circumflex, and 5 right coronary arteries) with substantial stenosis were visualized by both 64-slice MDCT and IB-IVUS. Coronary plaque was evaluated by MDCT and the findings were compared with those of IB-IVUS at the same sites and for the same vessel lengths. Plaque was classified as low-attenuated, fibrous, or calcified, and the volume of each plaque component and total plaque volume were calculated. Results: Total plaque volume per vessel determined by MDCT was significantly correlated with that determined by IB-IVUS (r = 0.704, P < 0.05, n = 17). However, the volumes of individual plaque components determined by the two approaches were not correlated. The predominant plaque morphology as determined by the two approaches was consistent in 12 of the 17 vessels (70.6%), whereas calcified and low-attenuated plaques were overestimated by MDCT in the remaining vessels. Conclusions: MDCT is a promising approach for noninvasive detection of different types of coronary plaque and may therefore contribute to coronary risk stratification. The ability of MDCT to determine the volume of individual plaque components, however, is limited.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalInternational Journal of Cardiology
Volume149
Issue number1
DOIs
Publication statusPublished - 19-05-2011
Externally publishedYes

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Multidetector Computed Tomography
Coronary Vessels
Pathologic Constriction

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Harada, Ken ; Amano, Tetsuya ; Uetani, Tadayuki ; Funahashi, Hidehito ; Arai, Kosuke ; Okada, Koji ; Hirashiki, Akihiro ; Hayashi, Mutsuharu ; Oshima, Satoru ; Ishii, Hideki ; Izawa, Hideo ; Matsubara, Tatsuaki ; Murohara, Toyoaki. / Accuracy of 64-slice multidetector computed tomography for classification and quantitation of coronary plaque : Comparison with integrated backscatter intravascular ultrasound. In: International Journal of Cardiology. 2011 ; Vol. 149, No. 1. pp. 95-101.
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title = "Accuracy of 64-slice multidetector computed tomography for classification and quantitation of coronary plaque: Comparison with integrated backscatter intravascular ultrasound",
abstract = "Background: Noninvasive assessment of coronary plaque is important for coronary risk stratification. Whereas integrated backscatter intravascular ultrasound (IB-IVUS) has proven effective for analysis of the tissue components of coronary plaque, plaque assessment by 64-slice multidetector computed tomography (MDCT) has not been established. We therefore evaluated the accuracy of MDCT compared with IB-IVUS for identification of coronary plaque components and determination of plaque volume. Methods: Thirty-one sites in 17 coronary vessels (7 left anterior descending, 5 left circumflex, and 5 right coronary arteries) with substantial stenosis were visualized by both 64-slice MDCT and IB-IVUS. Coronary plaque was evaluated by MDCT and the findings were compared with those of IB-IVUS at the same sites and for the same vessel lengths. Plaque was classified as low-attenuated, fibrous, or calcified, and the volume of each plaque component and total plaque volume were calculated. Results: Total plaque volume per vessel determined by MDCT was significantly correlated with that determined by IB-IVUS (r = 0.704, P < 0.05, n = 17). However, the volumes of individual plaque components determined by the two approaches were not correlated. The predominant plaque morphology as determined by the two approaches was consistent in 12 of the 17 vessels (70.6{\%}), whereas calcified and low-attenuated plaques were overestimated by MDCT in the remaining vessels. Conclusions: MDCT is a promising approach for noninvasive detection of different types of coronary plaque and may therefore contribute to coronary risk stratification. The ability of MDCT to determine the volume of individual plaque components, however, is limited.",
author = "Ken Harada and Tetsuya Amano and Tadayuki Uetani and Hidehito Funahashi and Kosuke Arai and Koji Okada and Akihiro Hirashiki and Mutsuharu Hayashi and Satoru Oshima and Hideki Ishii and Hideo Izawa and Tatsuaki Matsubara and Toyoaki Murohara",
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Harada, K, Amano, T, Uetani, T, Funahashi, H, Arai, K, Okada, K, Hirashiki, A, Hayashi, M, Oshima, S, Ishii, H, Izawa, H, Matsubara, T & Murohara, T 2011, 'Accuracy of 64-slice multidetector computed tomography for classification and quantitation of coronary plaque: Comparison with integrated backscatter intravascular ultrasound', International Journal of Cardiology, vol. 149, no. 1, pp. 95-101. https://doi.org/10.1016/j.ijcard.2010.04.002

Accuracy of 64-slice multidetector computed tomography for classification and quantitation of coronary plaque : Comparison with integrated backscatter intravascular ultrasound. / Harada, Ken; Amano, Tetsuya; Uetani, Tadayuki; Funahashi, Hidehito; Arai, Kosuke; Okada, Koji; Hirashiki, Akihiro; Hayashi, Mutsuharu; Oshima, Satoru; Ishii, Hideki; Izawa, Hideo; Matsubara, Tatsuaki; Murohara, Toyoaki.

In: International Journal of Cardiology, Vol. 149, No. 1, 19.05.2011, p. 95-101.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Accuracy of 64-slice multidetector computed tomography for classification and quantitation of coronary plaque

T2 - Comparison with integrated backscatter intravascular ultrasound

AU - Harada, Ken

AU - Amano, Tetsuya

AU - Uetani, Tadayuki

AU - Funahashi, Hidehito

AU - Arai, Kosuke

AU - Okada, Koji

AU - Hirashiki, Akihiro

AU - Hayashi, Mutsuharu

AU - Oshima, Satoru

AU - Ishii, Hideki

AU - Izawa, Hideo

AU - Matsubara, Tatsuaki

AU - Murohara, Toyoaki

PY - 2011/5/19

Y1 - 2011/5/19

N2 - Background: Noninvasive assessment of coronary plaque is important for coronary risk stratification. Whereas integrated backscatter intravascular ultrasound (IB-IVUS) has proven effective for analysis of the tissue components of coronary plaque, plaque assessment by 64-slice multidetector computed tomography (MDCT) has not been established. We therefore evaluated the accuracy of MDCT compared with IB-IVUS for identification of coronary plaque components and determination of plaque volume. Methods: Thirty-one sites in 17 coronary vessels (7 left anterior descending, 5 left circumflex, and 5 right coronary arteries) with substantial stenosis were visualized by both 64-slice MDCT and IB-IVUS. Coronary plaque was evaluated by MDCT and the findings were compared with those of IB-IVUS at the same sites and for the same vessel lengths. Plaque was classified as low-attenuated, fibrous, or calcified, and the volume of each plaque component and total plaque volume were calculated. Results: Total plaque volume per vessel determined by MDCT was significantly correlated with that determined by IB-IVUS (r = 0.704, P < 0.05, n = 17). However, the volumes of individual plaque components determined by the two approaches were not correlated. The predominant plaque morphology as determined by the two approaches was consistent in 12 of the 17 vessels (70.6%), whereas calcified and low-attenuated plaques were overestimated by MDCT in the remaining vessels. Conclusions: MDCT is a promising approach for noninvasive detection of different types of coronary plaque and may therefore contribute to coronary risk stratification. The ability of MDCT to determine the volume of individual plaque components, however, is limited.

AB - Background: Noninvasive assessment of coronary plaque is important for coronary risk stratification. Whereas integrated backscatter intravascular ultrasound (IB-IVUS) has proven effective for analysis of the tissue components of coronary plaque, plaque assessment by 64-slice multidetector computed tomography (MDCT) has not been established. We therefore evaluated the accuracy of MDCT compared with IB-IVUS for identification of coronary plaque components and determination of plaque volume. Methods: Thirty-one sites in 17 coronary vessels (7 left anterior descending, 5 left circumflex, and 5 right coronary arteries) with substantial stenosis were visualized by both 64-slice MDCT and IB-IVUS. Coronary plaque was evaluated by MDCT and the findings were compared with those of IB-IVUS at the same sites and for the same vessel lengths. Plaque was classified as low-attenuated, fibrous, or calcified, and the volume of each plaque component and total plaque volume were calculated. Results: Total plaque volume per vessel determined by MDCT was significantly correlated with that determined by IB-IVUS (r = 0.704, P < 0.05, n = 17). However, the volumes of individual plaque components determined by the two approaches were not correlated. The predominant plaque morphology as determined by the two approaches was consistent in 12 of the 17 vessels (70.6%), whereas calcified and low-attenuated plaques were overestimated by MDCT in the remaining vessels. Conclusions: MDCT is a promising approach for noninvasive detection of different types of coronary plaque and may therefore contribute to coronary risk stratification. The ability of MDCT to determine the volume of individual plaque components, however, is limited.

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