Action potential characteristics in the sinus venosa of patients with and without atrial flutter

Masahide Harada, Toshiyuki Osaka, Eriko Yokoyama, Yoshio Takemoto, Atsushi Ito, Itsuo Kodama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: A functional line of conduction block is often observed in the sinus venosa (SV) during typical atrial flutter (AFL). Little information, however, is available as to the action potential characteristics in the SV with respect to the functional block. Methods and Results: Monophasic action potentials (MAPs) from the SV and lateral wall of the right atrium were recorded in 7 patients with paroxysmal AFL and 11 control patients. For both the control and AFL patients, the MAP duration at 90% repolarization (MAPD90) in the SV was longer, and the MAPD90 restitution slope was less steep than in the lateral wall. The MAPD90 in the SV in the AFL patients was slightly longer than that in the controls at the shortest cycle length (CL) tested (300 ms). However, the MAPD90s at longer CLs (350-700 ms), as well as the MAPD90 restitution slopes in the SV were comparable between the 2 groups. Conclusions: The MAPs in the SV are characterized by a long duration and flat restitution kinetics in humans. MAP properties to facilitate the development of conduction block in the SV are not appreciable in patients with paroxysmal typical AFL.

Original languageEnglish
Pages (from-to)647-653
Number of pages7
JournalCirculation Journal
Volume73
Issue number4
DOIs
Publication statusPublished - 01-04-2009
Externally publishedYes

Fingerprint

Atrial Flutter
Action Potentials
Transverse Sinuses
Heart Atria

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Harada, Masahide ; Osaka, Toshiyuki ; Yokoyama, Eriko ; Takemoto, Yoshio ; Ito, Atsushi ; Kodama, Itsuo. / Action potential characteristics in the sinus venosa of patients with and without atrial flutter. In: Circulation Journal. 2009 ; Vol. 73, No. 4. pp. 647-653.
@article{740f4ca9c0fd4ec7bd13feea0b914efd,
title = "Action potential characteristics in the sinus venosa of patients with and without atrial flutter",
abstract = "Background: A functional line of conduction block is often observed in the sinus venosa (SV) during typical atrial flutter (AFL). Little information, however, is available as to the action potential characteristics in the SV with respect to the functional block. Methods and Results: Monophasic action potentials (MAPs) from the SV and lateral wall of the right atrium were recorded in 7 patients with paroxysmal AFL and 11 control patients. For both the control and AFL patients, the MAP duration at 90{\%} repolarization (MAPD90) in the SV was longer, and the MAPD90 restitution slope was less steep than in the lateral wall. The MAPD90 in the SV in the AFL patients was slightly longer than that in the controls at the shortest cycle length (CL) tested (300 ms). However, the MAPD90s at longer CLs (350-700 ms), as well as the MAPD90 restitution slopes in the SV were comparable between the 2 groups. Conclusions: The MAPs in the SV are characterized by a long duration and flat restitution kinetics in humans. MAP properties to facilitate the development of conduction block in the SV are not appreciable in patients with paroxysmal typical AFL.",
author = "Masahide Harada and Toshiyuki Osaka and Eriko Yokoyama and Yoshio Takemoto and Atsushi Ito and Itsuo Kodama",
year = "2009",
month = "4",
day = "1",
doi = "10.1253/circj.CJ-08-0748",
language = "English",
volume = "73",
pages = "647--653",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "4",

}

Action potential characteristics in the sinus venosa of patients with and without atrial flutter. / Harada, Masahide; Osaka, Toshiyuki; Yokoyama, Eriko; Takemoto, Yoshio; Ito, Atsushi; Kodama, Itsuo.

In: Circulation Journal, Vol. 73, No. 4, 01.04.2009, p. 647-653.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Action potential characteristics in the sinus venosa of patients with and without atrial flutter

AU - Harada, Masahide

AU - Osaka, Toshiyuki

AU - Yokoyama, Eriko

AU - Takemoto, Yoshio

AU - Ito, Atsushi

AU - Kodama, Itsuo

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Background: A functional line of conduction block is often observed in the sinus venosa (SV) during typical atrial flutter (AFL). Little information, however, is available as to the action potential characteristics in the SV with respect to the functional block. Methods and Results: Monophasic action potentials (MAPs) from the SV and lateral wall of the right atrium were recorded in 7 patients with paroxysmal AFL and 11 control patients. For both the control and AFL patients, the MAP duration at 90% repolarization (MAPD90) in the SV was longer, and the MAPD90 restitution slope was less steep than in the lateral wall. The MAPD90 in the SV in the AFL patients was slightly longer than that in the controls at the shortest cycle length (CL) tested (300 ms). However, the MAPD90s at longer CLs (350-700 ms), as well as the MAPD90 restitution slopes in the SV were comparable between the 2 groups. Conclusions: The MAPs in the SV are characterized by a long duration and flat restitution kinetics in humans. MAP properties to facilitate the development of conduction block in the SV are not appreciable in patients with paroxysmal typical AFL.

AB - Background: A functional line of conduction block is often observed in the sinus venosa (SV) during typical atrial flutter (AFL). Little information, however, is available as to the action potential characteristics in the SV with respect to the functional block. Methods and Results: Monophasic action potentials (MAPs) from the SV and lateral wall of the right atrium were recorded in 7 patients with paroxysmal AFL and 11 control patients. For both the control and AFL patients, the MAP duration at 90% repolarization (MAPD90) in the SV was longer, and the MAPD90 restitution slope was less steep than in the lateral wall. The MAPD90 in the SV in the AFL patients was slightly longer than that in the controls at the shortest cycle length (CL) tested (300 ms). However, the MAPD90s at longer CLs (350-700 ms), as well as the MAPD90 restitution slopes in the SV were comparable between the 2 groups. Conclusions: The MAPs in the SV are characterized by a long duration and flat restitution kinetics in humans. MAP properties to facilitate the development of conduction block in the SV are not appreciable in patients with paroxysmal typical AFL.

UR - http://www.scopus.com/inward/record.url?scp=65649088632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65649088632&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-08-0748

DO - 10.1253/circj.CJ-08-0748

M3 - Article

C2 - 19246809

AN - SCOPUS:65649088632

VL - 73

SP - 647

EP - 653

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 4

ER -