TY - JOUR
T1 - Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification
T2 - A comparison with Alzheimer disease
AU - Imamura, Kazuhiro
AU - Sawada, Makoto
AU - Ozaki, Norio
AU - Naito, Hiroshi
AU - Iwata, Nakao
AU - Ishihara, Ryoko
AU - Takeuchi, Toru
AU - Shibayama, Hiroto
PY - 2001
Y1 - 2001
N2 - Diffuse neurofibrillary tangles with calcification (DNTC) is an atypical dementia and is characterized pathologically by diffuse neurofibrillary tangles (NFTs) without senile plaques (SPs). In this study, we investigated the distribution of human leukocyte antigen (HLA)-DR-positive activated microglia in postmortem brain tissue of six patients with DNTC and six patients with Alzheimer disease (AD). HLA-DR-positive activated microglia were observed to associate with SPs in AD. In the DNTC brain, which lacks SPs, HLA-DR-positive microglia were mainly accumulated around weakly tau-positive NFTs, which were also positive for anti-amyloid-P and anti-C3d antibodies. The results of this study suggest that the complement pathway is also activated in the DNTC brain and that immune and inflammatory responses, including microglia activation, may occur around extracellular NFTs in DNTC patients.
AB - Diffuse neurofibrillary tangles with calcification (DNTC) is an atypical dementia and is characterized pathologically by diffuse neurofibrillary tangles (NFTs) without senile plaques (SPs). In this study, we investigated the distribution of human leukocyte antigen (HLA)-DR-positive activated microglia in postmortem brain tissue of six patients with DNTC and six patients with Alzheimer disease (AD). HLA-DR-positive activated microglia were observed to associate with SPs in AD. In the DNTC brain, which lacks SPs, HLA-DR-positive microglia were mainly accumulated around weakly tau-positive NFTs, which were also positive for anti-amyloid-P and anti-C3d antibodies. The results of this study suggest that the complement pathway is also activated in the DNTC brain and that immune and inflammatory responses, including microglia activation, may occur around extracellular NFTs in DNTC patients.
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U2 - 10.1097/00002093-200101000-00006
DO - 10.1097/00002093-200101000-00006
M3 - Article
C2 - 11236824
AN - SCOPUS:0035118004
SN - 0893-0341
VL - 15
SP - 45
EP - 50
JO - Alzheimer Disease and Associated Disorders
JF - Alzheimer Disease and Associated Disorders
IS - 1
ER -
