Activation of human herpesvirus‐6 in children with acute measles

Sadao Suga, Tetsushi Yoshikawa, Yoshizo Asano, Toshihiko Nakashima, Ikuko Kobayashi, Takehiko Yazaki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Virological and serological studies were carried out prospectively to evaluate the possible activation of human herpesvirus‐6 (HHV‐6) in 50 infants and children with acute measles by isolation of HHV‐6 from peripheral blood and by determining neutralizing antibodies to the virus. All but 5 patients (90%) were seropositive to HHV‐6 in the acute stage of measles and 18 (40%) had a significant increase in HHV‐6 antibody titers thereafter, whereas only 2 of 27 patients who were initially seropositive to Epstein‐Barr virus (EBV) viral capsid antigen (VCA) had a significant rise in antibody titers to EBV VCA. Among 18 patients with a significant increase in HHV‐6 titers, the virus was isolated from the peripheral blood mononuclear cells of three patients in the early convalescent stage of measles. These results indicate that activation of HHV‐6 may occur frequently a few weeks after primary infection with the measles virus. © 1992 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)278-282
Number of pages5
JournalJournal of Medical Virology
Volume38
Issue number4
DOIs
Publication statusPublished - 01-01-1992

Fingerprint

Measles
Viral Antigens
Capsid
Viruses
Measles virus
Antibodies
Neutralizing Antibodies
Viral Load
Blood Cells
Infection

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology

Cite this

Suga, Sadao ; Yoshikawa, Tetsushi ; Asano, Yoshizo ; Nakashima, Toshihiko ; Kobayashi, Ikuko ; Yazaki, Takehiko. / Activation of human herpesvirus‐6 in children with acute measles. In: Journal of Medical Virology. 1992 ; Vol. 38, No. 4. pp. 278-282.
@article{c1e707b7476a49ddb395c864bc3b3e3a,
title = "Activation of human herpesvirus‐6 in children with acute measles",
abstract = "Virological and serological studies were carried out prospectively to evaluate the possible activation of human herpesvirus‐6 (HHV‐6) in 50 infants and children with acute measles by isolation of HHV‐6 from peripheral blood and by determining neutralizing antibodies to the virus. All but 5 patients (90{\%}) were seropositive to HHV‐6 in the acute stage of measles and 18 (40{\%}) had a significant increase in HHV‐6 antibody titers thereafter, whereas only 2 of 27 patients who were initially seropositive to Epstein‐Barr virus (EBV) viral capsid antigen (VCA) had a significant rise in antibody titers to EBV VCA. Among 18 patients with a significant increase in HHV‐6 titers, the virus was isolated from the peripheral blood mononuclear cells of three patients in the early convalescent stage of measles. These results indicate that activation of HHV‐6 may occur frequently a few weeks after primary infection with the measles virus. {\circledC} 1992 Wiley‐Liss, Inc.",
author = "Sadao Suga and Tetsushi Yoshikawa and Yoshizo Asano and Toshihiko Nakashima and Ikuko Kobayashi and Takehiko Yazaki",
year = "1992",
month = "1",
day = "1",
doi = "10.1002/jmv.1890380409",
language = "English",
volume = "38",
pages = "278--282",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "4",

}

Suga, S, Yoshikawa, T, Asano, Y, Nakashima, T, Kobayashi, I & Yazaki, T 1992, 'Activation of human herpesvirus‐6 in children with acute measles', Journal of Medical Virology, vol. 38, no. 4, pp. 278-282. https://doi.org/10.1002/jmv.1890380409

Activation of human herpesvirus‐6 in children with acute measles. / Suga, Sadao; Yoshikawa, Tetsushi; Asano, Yoshizo; Nakashima, Toshihiko; Kobayashi, Ikuko; Yazaki, Takehiko.

In: Journal of Medical Virology, Vol. 38, No. 4, 01.01.1992, p. 278-282.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Activation of human herpesvirus‐6 in children with acute measles

AU - Suga, Sadao

AU - Yoshikawa, Tetsushi

AU - Asano, Yoshizo

AU - Nakashima, Toshihiko

AU - Kobayashi, Ikuko

AU - Yazaki, Takehiko

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Virological and serological studies were carried out prospectively to evaluate the possible activation of human herpesvirus‐6 (HHV‐6) in 50 infants and children with acute measles by isolation of HHV‐6 from peripheral blood and by determining neutralizing antibodies to the virus. All but 5 patients (90%) were seropositive to HHV‐6 in the acute stage of measles and 18 (40%) had a significant increase in HHV‐6 antibody titers thereafter, whereas only 2 of 27 patients who were initially seropositive to Epstein‐Barr virus (EBV) viral capsid antigen (VCA) had a significant rise in antibody titers to EBV VCA. Among 18 patients with a significant increase in HHV‐6 titers, the virus was isolated from the peripheral blood mononuclear cells of three patients in the early convalescent stage of measles. These results indicate that activation of HHV‐6 may occur frequently a few weeks after primary infection with the measles virus. © 1992 Wiley‐Liss, Inc.

AB - Virological and serological studies were carried out prospectively to evaluate the possible activation of human herpesvirus‐6 (HHV‐6) in 50 infants and children with acute measles by isolation of HHV‐6 from peripheral blood and by determining neutralizing antibodies to the virus. All but 5 patients (90%) were seropositive to HHV‐6 in the acute stage of measles and 18 (40%) had a significant increase in HHV‐6 antibody titers thereafter, whereas only 2 of 27 patients who were initially seropositive to Epstein‐Barr virus (EBV) viral capsid antigen (VCA) had a significant rise in antibody titers to EBV VCA. Among 18 patients with a significant increase in HHV‐6 titers, the virus was isolated from the peripheral blood mononuclear cells of three patients in the early convalescent stage of measles. These results indicate that activation of HHV‐6 may occur frequently a few weeks after primary infection with the measles virus. © 1992 Wiley‐Liss, Inc.

UR - http://www.scopus.com/inward/record.url?scp=0026727257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026727257&partnerID=8YFLogxK

U2 - 10.1002/jmv.1890380409

DO - 10.1002/jmv.1890380409

M3 - Article

C2 - 1335483

AN - SCOPUS:0026727257

VL - 38

SP - 278

EP - 282

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 4

ER -