TY - JOUR
T1 - Activation of moesin and adducin by Rho-kinase downstream of Rho
AU - Fukata, Yuko
AU - Oshiro, Noriko
AU - Kaibuchi, Kozo
N1 - Funding Information:
The work in the authors’ laboratory was supported by a grant from the Research for the Future Program of the Japan Society of the Promotion of Science, and by the Human Frontier Science Program.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/12/13
Y1 - 1999/12/13
N2 - The Rho GTPase (Rho) is a member of the Rho family, which belongs to the Ras superfamily of GTP-binding proteins. Like other GTP-binding proteins, Rho exists in two conformational states, an inactive GDP-bound form and an active GTP-bound form. Active Rho interacts with specific effectors to regulate the actin cytoskeleton and to mediate a variety of biological functions in cells. Rho-associated kinase (Rho-kinase) is the most studied Rho-effector, and studies of its biochemical and cell biological functions have provided us with useful information for understanding the molecular mechanisms of the actions of Rho. This review aims to summarize the roles of Rho and Rho-kinase in the regulation of the cytoskeletons. Copyright (C) 1999 Elsevier Science B.V.
AB - The Rho GTPase (Rho) is a member of the Rho family, which belongs to the Ras superfamily of GTP-binding proteins. Like other GTP-binding proteins, Rho exists in two conformational states, an inactive GDP-bound form and an active GTP-bound form. Active Rho interacts with specific effectors to regulate the actin cytoskeleton and to mediate a variety of biological functions in cells. Rho-associated kinase (Rho-kinase) is the most studied Rho-effector, and studies of its biochemical and cell biological functions have provided us with useful information for understanding the molecular mechanisms of the actions of Rho. This review aims to summarize the roles of Rho and Rho-kinase in the regulation of the cytoskeletons. Copyright (C) 1999 Elsevier Science B.V.
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U2 - 10.1016/S0301-4622(99)00113-1
DO - 10.1016/S0301-4622(99)00113-1
M3 - Article
C2 - 10631797
AN - SCOPUS:0033552677
VL - 82
SP - 139
EP - 147
JO - Biophysical Chemistry
JF - Biophysical Chemistry
SN - 0301-4622
IS - 2-3
ER -