Activation of moesin and adducin by Rho-kinase downstream of Rho

Yuko Fukata, Noriko Oshiro, Kozo Kaibuchi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The Rho GTPase (Rho) is a member of the Rho family, which belongs to the Ras superfamily of GTP-binding proteins. Like other GTP-binding proteins, Rho exists in two conformational states, an inactive GDP-bound form and an active GTP-bound form. Active Rho interacts with specific effectors to regulate the actin cytoskeleton and to mediate a variety of biological functions in cells. Rho-associated kinase (Rho-kinase) is the most studied Rho-effector, and studies of its biochemical and cell biological functions have provided us with useful information for understanding the molecular mechanisms of the actions of Rho. This review aims to summarize the roles of Rho and Rho-kinase in the regulation of the cytoskeletons. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)139-147
Number of pages9
JournalBiophysical Chemistry
Volume82
Issue number2-3
DOIs
Publication statusPublished - 13-12-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Activation of moesin and adducin by Rho-kinase downstream of Rho'. Together they form a unique fingerprint.

  • Cite this