Abstract
Mezerein, classified as a second-stage tumor promoter, has no diacylglycerol-like structure in its molecule, but can activate protein kinase C both in vitro and in vivo. This non-phorbol diterpene competitively inhibits the specific binding of a radioactive tumor-promoting phorbol ester to the enzyme. It is suggestive that tumor-promoting phorbol esters and mezerein cause analogous changes in the membrane to activate protein kinase C, and utilize this protein kinase as a common receptive protein for tumor promotion.
Original language | English |
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Pages (from-to) | 649-656 |
Number of pages | 8 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 121 |
Issue number | 2 |
DOIs | |
Publication status | Published - 15-06-1984 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology