Activation of the heart by donor brain death accelerates acute rejection after transplantation

M. J. Wilhelm, J. Pratschke, F. Beato, M. Taal, M. Kusaka, W. W. Hancock, N. L. Tilney

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Background - Donor brain death upregulates expression of inflammatory mediators in the heart. It is hypothesized that these nonspecific changes trigger and amplify acute rejection in unmodified recipients compared with hearts from normal living donors. We examined the inflammatory and immunological consequences of gradual-onset donor brain death on cardiac allografts after tra nsplantation. Methods and Results - Functioning hearts were engrafted from normotensive donors after 6 hours of ventilatory support. Hearts from brain-dead rats (Fisher, F344) were rejected significantly earlier (mean ± SD, 9.3 ± 0.6 days) by their (Lewis) recipients than hearts from living donor controls (11.6 ± 0.7 days, P=0.03). The inflammatory response of such organs was accelerated, with rapid expression of cytokines, chemokines, and adhesion molecules and brisk infiltration of associated leukocyte populations. Upregulation of major histocompatibility class II antigens increased organ immuno genicity. Acute rejection evolved in hearts from brain-dead donors more intensely and at a significantly faster rate than in controls. Conclusions - Donor brain death is deleterious to transplanted hearts. The resultant upregulation of inflammatory factors provokes host immune mechanisms and accelerates the acute rejection process in unmodified hosts.

Original languageEnglish
Pages (from-to)2426-2433
Number of pages8
JournalCirculation
Volume102
Issue number19 SUPPL.
DOIs
Publication statusPublished - 07-11-2000

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Activation of the heart by donor brain death accelerates acute rejection after transplantation'. Together they form a unique fingerprint.

Cite this