Activation of the serum-response and TPA-response elements by expression of the v-abl protein: Comparison of the mode of acxtion of the v-abl protein with those of protein kinase C, cyclic AMP-dependent protein kinase, and the activated c-raf protein

Y. Hori, K. Kaibuchi, Y. Fukumoto, N. Oku, Y. Takai

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

In the present study, we have compared the mode of action of the v-abl protein in the regulation of gene expression with those of serine/threonine protein kinases such as protein kinase C, cyclic AMP-dependent protein kinase, and the activated c-raf protein, by measuring the transcriptional activity of the serum-response element, the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element, and the cyclic AMP-response element in NIH3T3 cells transfected with the v-abl gene. The results indicate that the v-abl protein stimulates the serum-response element and the TPA-response element, but not the cyclic AMP-response element, in a manner similar to that of the activated c-raf protein, but different from those of protein kinase C and cyclic AMP-dependent protein kinase.

Original languageEnglish
Pages (from-to)1201-1206
Number of pages6
JournalOncogene
Volume5
Issue number8
Publication statusPublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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