Active smoking, passive smoking, and breast cancer risk: Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk

Yingsong Lin, Shogo Kikuchi, Koji Tamakoshi, Kenji Wakai, Takaaki Kondo, Yoshimitsu Niwa, Hiroshi Yatsuya, Kazuko Nishio, Sadao Suzuki, Shinkan Tokudome, Akio Yamamoto, Hideaki Toyoshima, Mitsuru Mori, Akiko Tamakoshi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka InabaYoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Yoshinori Ito, Shuji Hashimoto, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

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Abstract

Background: Evidence is lacking regarding the relationship between cigarette smoking and breast cancer in Japanese women. We examined the association between breast cancer incidence and active and passive smoking in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Methods: Our study comprised 34,401 women aged 40-79 years who had not been diagnosed previously with breast cancer and who provided information on smoking status at baseline (1988-1990). The subjects were followed from enrollment until December 31, 2001. Cox proportional-hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for the association between breast cancer incidence and tobacco smoke. Results: During 271,412 person-years of follow-up, we identified 208 incident cases of breast cancer. Active smoking did not increase the risk of breast cancer, with a HR for current smokers of 0.67 (95% CI: 0.32-1.38). Furthermore, an increased risk of breast cancer was not observed in current smokers who smoked a greater number of cigarettes each day. Overall, passive smoking at home or in public spaces was also not associated with an increased risk of breast cancer among nonsmokers. Women who reported passive smoking during childhood had a statistically insignificant increase in risk (HR: 1.24; 95% CI: 0.84-1.85), compared with those who had not been exposed during this time. Conclusion: Smoking may not be associated with an increased risk of breast cancer in this cohort of Japanese women.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalJournal of epidemiology
Volume18
Issue number2
DOIs
Publication statusPublished - 14-05-2008

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Tobacco Smoke Pollution
Japan
Cohort Studies
Smoking
Breast Neoplasms
Neoplasms
Confidence Intervals
Incidence
Proportional Hazards Models
Smoke
Tobacco Products
Tobacco
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Epidemiology

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Lin, Yingsong ; Kikuchi, Shogo ; Tamakoshi, Koji ; Wakai, Kenji ; Kondo, Takaaki ; Niwa, Yoshimitsu ; Yatsuya, Hiroshi ; Nishio, Kazuko ; Suzuki, Sadao ; Tokudome, Shinkan ; Yamamoto, Akio ; Toyoshima, Hideaki ; Mori, Mitsuru ; Tamakoshi, Akiko ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Ito, Yoshinori ; Hashimoto, Shuji ; Koizumi, Akio ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / Active smoking, passive smoking, and breast cancer risk : Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. In: Journal of epidemiology. 2008 ; Vol. 18, No. 2. pp. 77-83.
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title = "Active smoking, passive smoking, and breast cancer risk: Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk",
abstract = "Background: Evidence is lacking regarding the relationship between cigarette smoking and breast cancer in Japanese women. We examined the association between breast cancer incidence and active and passive smoking in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Methods: Our study comprised 34,401 women aged 40-79 years who had not been diagnosed previously with breast cancer and who provided information on smoking status at baseline (1988-1990). The subjects were followed from enrollment until December 31, 2001. Cox proportional-hazards models were used to estimate the hazard ratio (HR) and 95{\%} confidence interval (CI) for the association between breast cancer incidence and tobacco smoke. Results: During 271,412 person-years of follow-up, we identified 208 incident cases of breast cancer. Active smoking did not increase the risk of breast cancer, with a HR for current smokers of 0.67 (95{\%} CI: 0.32-1.38). Furthermore, an increased risk of breast cancer was not observed in current smokers who smoked a greater number of cigarettes each day. Overall, passive smoking at home or in public spaces was also not associated with an increased risk of breast cancer among nonsmokers. Women who reported passive smoking during childhood had a statistically insignificant increase in risk (HR: 1.24; 95{\%} CI: 0.84-1.85), compared with those who had not been exposed during this time. Conclusion: Smoking may not be associated with an increased risk of breast cancer in this cohort of Japanese women.",
author = "Yingsong Lin and Shogo Kikuchi and Koji Tamakoshi and Kenji Wakai and Takaaki Kondo and Yoshimitsu Niwa and Hiroshi Yatsuya and Kazuko Nishio and Sadao Suzuki and Shinkan Tokudome and Akio Yamamoto and Hideaki Toyoshima and Mitsuru Mori and Akiko Tamakoshi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Yoshinori Ito and Shuji Hashimoto and Akio Koizumi and Takashi Kawamura and Yoshiyuki Watanabe and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
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Lin, Y, Kikuchi, S, Tamakoshi, K, Wakai, K, Kondo, T, Niwa, Y, Yatsuya, H, Nishio, K, Suzuki, S, Tokudome, S, Yamamoto, A, Toyoshima, H, Mori, M, Tamakoshi, A, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Ito, Y, Hashimoto, S, Koizumi, A, Kawamura, T, Watanabe, Y, Miki, T, Date, C, Sakata, K, Nose, T, Hayakawa, N, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T & Tajima, K 2008, 'Active smoking, passive smoking, and breast cancer risk: Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk', Journal of epidemiology, vol. 18, no. 2, pp. 77-83. https://doi.org/10.2188/jea.18.77

Active smoking, passive smoking, and breast cancer risk : Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. / Lin, Yingsong; Kikuchi, Shogo; Tamakoshi, Koji; Wakai, Kenji; Kondo, Takaaki; Niwa, Yoshimitsu; Yatsuya, Hiroshi; Nishio, Kazuko; Suzuki, Sadao; Tokudome, Shinkan; Yamamoto, Akio; Toyoshima, Hideaki; Mori, Mitsuru; Tamakoshi, Akiko; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Ito, Yoshinori; Hashimoto, Shuji; Koizumi, Akio; Kawamura, Takashi; Watanabe, Yoshiyuki; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

In: Journal of epidemiology, Vol. 18, No. 2, 14.05.2008, p. 77-83.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Active smoking, passive smoking, and breast cancer risk

T2 - Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk

AU - Lin, Yingsong

AU - Kikuchi, Shogo

AU - Tamakoshi, Koji

AU - Wakai, Kenji

AU - Kondo, Takaaki

AU - Niwa, Yoshimitsu

AU - Yatsuya, Hiroshi

AU - Nishio, Kazuko

AU - Suzuki, Sadao

AU - Tokudome, Shinkan

AU - Yamamoto, Akio

AU - Toyoshima, Hideaki

AU - Mori, Mitsuru

AU - Tamakoshi, Akiko

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Ito, Yoshinori

AU - Hashimoto, Shuji

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2008/5/14

Y1 - 2008/5/14

N2 - Background: Evidence is lacking regarding the relationship between cigarette smoking and breast cancer in Japanese women. We examined the association between breast cancer incidence and active and passive smoking in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Methods: Our study comprised 34,401 women aged 40-79 years who had not been diagnosed previously with breast cancer and who provided information on smoking status at baseline (1988-1990). The subjects were followed from enrollment until December 31, 2001. Cox proportional-hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for the association between breast cancer incidence and tobacco smoke. Results: During 271,412 person-years of follow-up, we identified 208 incident cases of breast cancer. Active smoking did not increase the risk of breast cancer, with a HR for current smokers of 0.67 (95% CI: 0.32-1.38). Furthermore, an increased risk of breast cancer was not observed in current smokers who smoked a greater number of cigarettes each day. Overall, passive smoking at home or in public spaces was also not associated with an increased risk of breast cancer among nonsmokers. Women who reported passive smoking during childhood had a statistically insignificant increase in risk (HR: 1.24; 95% CI: 0.84-1.85), compared with those who had not been exposed during this time. Conclusion: Smoking may not be associated with an increased risk of breast cancer in this cohort of Japanese women.

AB - Background: Evidence is lacking regarding the relationship between cigarette smoking and breast cancer in Japanese women. We examined the association between breast cancer incidence and active and passive smoking in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Methods: Our study comprised 34,401 women aged 40-79 years who had not been diagnosed previously with breast cancer and who provided information on smoking status at baseline (1988-1990). The subjects were followed from enrollment until December 31, 2001. Cox proportional-hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for the association between breast cancer incidence and tobacco smoke. Results: During 271,412 person-years of follow-up, we identified 208 incident cases of breast cancer. Active smoking did not increase the risk of breast cancer, with a HR for current smokers of 0.67 (95% CI: 0.32-1.38). Furthermore, an increased risk of breast cancer was not observed in current smokers who smoked a greater number of cigarettes each day. Overall, passive smoking at home or in public spaces was also not associated with an increased risk of breast cancer among nonsmokers. Women who reported passive smoking during childhood had a statistically insignificant increase in risk (HR: 1.24; 95% CI: 0.84-1.85), compared with those who had not been exposed during this time. Conclusion: Smoking may not be associated with an increased risk of breast cancer in this cohort of Japanese women.

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