Activin induces long-lasting N-methyl-d-aspartate receptor activation via scaffolding PDZ protein activin receptor interacting protein 1

A. Kurisaki, I. Inoue, K. Kurisaki, N. Yamakawa, Kunihiro Tsuchida, H. Sugino

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Calcium entry into the postsynaptic neuron through N-methyl-d-aspartate-type glutamate receptors (NMDARs) triggers the induction of long-term potentiation (LTP), which is considered to contribute to synaptic plasticity and plays a critical role in behavioral learning. We report here that activin, a member of the transforming growth factor-β (TGF-β) superfamily, promotes phosphorylation of NMDARs and increases the Ca2+ influx through these receptors in primary cultured rat hippocampal neurons. This signal transduction occurs in a functional complex of activin receptors, NMDARs, and Src family tyrosine kinases, including Fyn, formed on a multimer of postsynaptic scaffolding postsynaptic density protein 95/Dlg/ZO-1 (PDZ), activin receptor interacting protein 1 (ARIP1). Activin-induced NMDAR activation persists for more than 24 h, which is complimentary to the activation time of NMDARs by brain-derived neurotrophic factor (BDNF). Our results suggest that activin is a unique and powerful potentiator for NMDAR-dependent signaling, which could be involved in the regulatory mechanisms of synaptic plasticity.

Original languageEnglish
Pages (from-to)1225-1235
Number of pages11
JournalNeuroscience
Volume151
Issue number4
DOIs
Publication statusPublished - 19-02-2008

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Activin Receptors
Receptor-Interacting Protein Serine-Threonine Kinases
Activins
Glutamate Receptors
Proteins
Neuronal Plasticity
Neurons
src-Family Kinases
Long-Term Potentiation
Brain-Derived Neurotrophic Factor
Transforming Growth Factors
aspartic acid receptor
Signal Transduction
Phosphorylation
Learning
Calcium

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kurisaki, A. ; Inoue, I. ; Kurisaki, K. ; Yamakawa, N. ; Tsuchida, Kunihiro ; Sugino, H. / Activin induces long-lasting N-methyl-d-aspartate receptor activation via scaffolding PDZ protein activin receptor interacting protein 1. In: Neuroscience. 2008 ; Vol. 151, No. 4. pp. 1225-1235.
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Activin induces long-lasting N-methyl-d-aspartate receptor activation via scaffolding PDZ protein activin receptor interacting protein 1. / Kurisaki, A.; Inoue, I.; Kurisaki, K.; Yamakawa, N.; Tsuchida, Kunihiro; Sugino, H.

In: Neuroscience, Vol. 151, No. 4, 19.02.2008, p. 1225-1235.

Research output: Contribution to journalArticle

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