Activin isoforms signal through type I receptor serine/threonine kinase ALK7

Kunihiro Tsuchida, Masashi Nakatani, Norio Yamakawa, Osamu Hashimoto, Yoshihisa Hasegawa, Hiromu Sugino

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Activins play a fundamental role in cell differentiation and development. Activin A signaling is mediated through a combination of activin type II receptors (ActRIIs) and the activin type IB receptor, ALK4. Signaling receptors of other activin isoforms remain to be elucidated. Here, we found that activin AB and activin B are ligands for ALK7. ALK7 is an orphan receptor serine/threonine kinase expressed in neuroendocrine tissues including pancreatic islets. The combination of ActRIIA and ALK7, preferred by activin AB and activin B but not by activin A, is responsible for activin-mediated secretion of insulin from pancreatic β cell line, MIN6. In contrast, all activins activate a combination of ActRIIA and ALK4 with various levels of potency. Thus, variation in activin signaling through type I receptors is dependent upon homo- and heterodimeric assembly of activin isoforms. Thus, the differential combination of receptor heterodimers mediates variation in activin isoform signaling.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume220
Issue number1-2
DOIs
Publication statusPublished - 31-05-2004

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Activins
Protein-Serine-Threonine Kinases
Protein Isoforms
Activin Receptors
Type II Activin Receptors
Islets of Langerhans
Cell Differentiation
Insulin
Ligands
Cell Line
Cells
Tissue

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Tsuchida, Kunihiro ; Nakatani, Masashi ; Yamakawa, Norio ; Hashimoto, Osamu ; Hasegawa, Yoshihisa ; Sugino, Hiromu. / Activin isoforms signal through type I receptor serine/threonine kinase ALK7. In: Molecular and Cellular Endocrinology. 2004 ; Vol. 220, No. 1-2. pp. 59-65.
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Activin isoforms signal through type I receptor serine/threonine kinase ALK7. / Tsuchida, Kunihiro; Nakatani, Masashi; Yamakawa, Norio; Hashimoto, Osamu; Hasegawa, Yoshihisa; Sugino, Hiromu.

In: Molecular and Cellular Endocrinology, Vol. 220, No. 1-2, 31.05.2004, p. 59-65.

Research output: Contribution to journalArticle

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