Activin plays a key role in the maintenance of long-term memory and late-LTP

Hiroshi Ageta, Shiro Ikegami, Masami Miura, Masao Masuda, Rika Migishima, Toshiaki Hino, Noriko Takashima, Akiko Murayama, Hiromu Sugino, Mitsutoshi Setou, Satoshi Kida, Minesuke Yokoyama, Yoshihisa Hasegawa, Kunihiro Tsuchida, Toshihiko Aosaki, Kaoru Inokuchi

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36 Citations (Scopus)

Abstract

A recent study has revealed that fear memory may be vulnerable following retrieval, and is then reconsolidated in a protein synthesis-dependent manner. However, little is known about the molecular mechanisms of these processes. Activin βA, a member of the TGF-β superfamily, is increased in activated neuronal circuits and regulates dendritic spine morphology. To clarify the role of activin in the synaptic plasticity of the adult brain, we examined the effect of inhibiting or enhancing activin function on hippocampal long-term potentiation (LTP). We found that follistatin, a specific inhibitor of activin, blocked the maintenance of late LTP (L-LTP) in the hippocampus. In contrast, administration of activin facilitated the maintenance of early LTP (E-LTP). We generated forebrain-specific activin- or follistatin-transgenic mice in which transgene expression is under the control of the Tet-OFF system. Maintenance of hippocampal L-LTP was blocked in the follistatin-transgenic mice. In the contextual fear-conditioning test, we found that follistatin blocked the formation of long-term memory (LTM) without affecting short-term memory (STM). Furthermore, consolidated memory was selectively weakened by the expression of follistatin during retrieval, but not during the maintenance phase. On the other hand, the maintenance of memory was also influenced by activin overexpression during the retrieval phase. Thus, the level of activin in the brain during the retrieval phase plays a key role in the maintenance of long-term memory.

Original languageEnglish
Pages (from-to)176-185
Number of pages10
JournalLearning and Memory
Volume17
Issue number4
DOIs
Publication statusPublished - 01-04-2010

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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  • Cite this

    Ageta, H., Ikegami, S., Miura, M., Masuda, M., Migishima, R., Hino, T., Takashima, N., Murayama, A., Sugino, H., Setou, M., Kida, S., Yokoyama, M., Hasegawa, Y., Tsuchida, K., Aosaki, T., & Inokuchi, K. (2010). Activin plays a key role in the maintenance of long-term memory and late-LTP. Learning and Memory, 17(4), 176-185. https://doi.org/10.1101/lm.16659010