Acute and chronic effects of pentobarbital on 5-hydroxytryptamine in mouse brain

Toshitaka Nabeshima, Ing K. Ho

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


1. 1. The influence of acute and chronic administration of pentobarbital on the brain 5-hydroxytryptamine systems was investigated in mice. 2. 2. Treatment of the animals with sodium pentobarbital, 75 mg/kg, i.p., resulted in an increase of 5-hydroxytryptamine and a decrease of 5-hydroxyindoleacetic acid levels. 3. 3. Acute pentobarbital treatment also caused the reduction of 5-hydroxytryptamine turnover without an equivalent decrease in 5-hydroxytryptamine synthesis. However, the 5-hydroxytryptamine synthesis was significantly decreased in animals which have developed tolerance to pentobarbital. 4. 4. The pretreatment of animals with p{combining macron below}-chlorophenylalanine attenuated the development of tolerance to pentobarbital without altering the response of the animal to acute administration pentobarbital. 5. 5. On the other hand, no significant change was observed in 5-hydroxytryptamine systems in pentobarbital-withdrawal groups. 6. 6. These results strongly suggest that functional states of brain serotonergic systems may be involved in barbiturate action.

Original languageEnglish
Pages (from-to)373-381
Number of pages9
JournalProgress in Neuro-Psychopharmacology
Issue number4
Publication statusPublished - 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)
  • General Neuroscience


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