Acute cellular rejection occurring on the first day after living-related renal transplantation: A case report

Michihiro Maruyama, Takashi Kenmochi, Kenichi Saigo, Naotake Akutsu, Chikara Iwashita, Kazunori Ohtsuki, Hiroshi Kitamura, Kensuke Joh

Research output: Contribution to journalArticle

Abstract

The patient was a 52-year-old man who received an ABO-compatible but non-identical living-related renal graft from his wife. The graft started to function immediately and the urine output rate was over 100 mL/h. However, this was gradually decreased within 12 h after transplantation. On day 2 post-transplant, the urine output almost stopped. A biopsy specimen revealed lymphocyte dominant cellular infiltration in the interstitium with mild tubulitis (according to Banff's schema grade Ia) and no C4d deposition in peritubular capillaries. Immunohistochemistry disclosed T-cell infiltration. The patient responded to a course of steroid pulse therapy (five days of 500 mg of methylprednisolone). The urine output gradually increased and the level of serum creatinine gradually decreased to 1.0 mg/dL. These clinical and histological findings strongly suggested acute cellular rejection. Acute cellular rejection occurring within 24 h post-transplant is extremely rare. In the present case acute cellular rejection occurred within the first day after living-related renal transplantation and was strongly suspected from histopathological findings in the allograft biopsy specimen.

Original languageEnglish
Pages (from-to)38-41
Number of pages4
JournalClinical Transplantation
Volume20
Issue numberSUPPL. 15
DOIs
Publication statusPublished - 01-07-2006

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Kidney Transplantation
Transplants
Urine
Biopsy
Methylprednisolone
Spouses
Allografts
Creatinine
Transplantation
Immunohistochemistry
Steroids
Lymphocytes
T-Lymphocytes
Kidney
Rejection (Psychology)
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Maruyama, Michihiro ; Kenmochi, Takashi ; Saigo, Kenichi ; Akutsu, Naotake ; Iwashita, Chikara ; Ohtsuki, Kazunori ; Kitamura, Hiroshi ; Joh, Kensuke. / Acute cellular rejection occurring on the first day after living-related renal transplantation : A case report. In: Clinical Transplantation. 2006 ; Vol. 20, No. SUPPL. 15. pp. 38-41.
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Acute cellular rejection occurring on the first day after living-related renal transplantation : A case report. / Maruyama, Michihiro; Kenmochi, Takashi; Saigo, Kenichi; Akutsu, Naotake; Iwashita, Chikara; Ohtsuki, Kazunori; Kitamura, Hiroshi; Joh, Kensuke.

In: Clinical Transplantation, Vol. 20, No. SUPPL. 15, 01.07.2006, p. 38-41.

Research output: Contribution to journalArticle

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AU - Kitamura, Hiroshi

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