TY - JOUR
T1 - Acute homeostatic responses to increased fat consumption in MCH1R knockout mice
AU - Chung, Shinjae
AU - Wong, Timothy
AU - Nagasaki, Hiroshi
AU - Civelli, Olivier
N1 - Funding Information:
Acknowledgments We would like to thank Dr. Su Qian in Merck for providing us with MCH1R KO mice. We would also like to thank Dr. Qun-Yong Zhou and Dr. Jia-Da Li for helpful discussion and helping us with metabolism assay. This work was supported by grants MH60231 and DA024746 to O.C. S.C. is supported by Davis Foundation Postdoctoral Fellowship Program in Eating Disorders Research supported by Hilda and Preston Davis Foundation.
PY - 2010/11
Y1 - 2010/11
N2 - Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide which has been shown to regulate energy homeostasis. Using genetic knockout mice lacking the MCH1 receptor (MCH1R), we investigated how these mice adapt to metabolic changes caused by excessive caloric consumption. We show that the MCH system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption. MCH1R knockout mice showed decreased tendency of food intake upon exposure to a high-fat diet. They also are resistant to gain weight upon high-fat diet by increasing fat metabolism. Therefore, the MCH system is important in regulating metabolic responses upon various environmental stimuli such as high-fat diet.
AB - Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide which has been shown to regulate energy homeostasis. Using genetic knockout mice lacking the MCH1 receptor (MCH1R), we investigated how these mice adapt to metabolic changes caused by excessive caloric consumption. We show that the MCH system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption. MCH1R knockout mice showed decreased tendency of food intake upon exposure to a high-fat diet. They also are resistant to gain weight upon high-fat diet by increasing fat metabolism. Therefore, the MCH system is important in regulating metabolic responses upon various environmental stimuli such as high-fat diet.
KW - Energy homeostasis
KW - G protein-coupled receptor
KW - Melanin-concentrating hormone
KW - Neuropeptide
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U2 - 10.1007/s12031-010-9358-5
DO - 10.1007/s12031-010-9358-5
M3 - Article
C2 - 20411353
AN - SCOPUS:78349310531
SN - 0895-8696
VL - 42
SP - 459
EP - 463
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
IS - 3
ER -