Acute homeostatic responses to increased fat consumption in MCH1R knockout mice

Shinjae Chung, Timothy Wong, Hiroshi Nagasaki, Olivier Civelli

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide which has been shown to regulate energy homeostasis. Using genetic knockout mice lacking the MCH1 receptor (MCH1R), we investigated how these mice adapt to metabolic changes caused by excessive caloric consumption. We show that the MCH system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption. MCH1R knockout mice showed decreased tendency of food intake upon exposure to a high-fat diet. They also are resistant to gain weight upon high-fat diet by increasing fat metabolism. Therefore, the MCH system is important in regulating metabolic responses upon various environmental stimuli such as high-fat diet.

Original languageEnglish
Pages (from-to)459-463
Number of pages5
JournalJournal of Molecular Neuroscience
Issue number3
Publication statusPublished - 11-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience


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