Acute phencyclidine induces aversion, but repeated phencyclidine induces preference in the place conditioning test in rats

Kiyoyuki Kitaichi, Yukihiro Noda, Takaaki Hasegawa, Hiroshi Furukawa, Toshitaka Nabeshima

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Phencyclidine (PCP) is a drug that has been widely abused in the past two decades. PCP produces place aversion, but not preference, in the place conditioning test. The present study examined PCP-induced place conditioning behavior in rats treated with PCP repeatedly. In naive rats, PCP (2-8 mg/kg i.p.) dose dependently produced place aversion, but did not produce any effect in rats treated with PCP (10 mg/kg i.p.) for 14 days, indicating that tolerance developed to PCP-induced place aversion on repeated PCP treatment. In rats treated with PCP (10 mg/kg i.p.) for 28 days, PCP (2-8 mg/kg i.p.) dose dependently produced place preference. These findings suggest that some changes in neuronal function induced by the repeated PCP treatment may play an important role in the addiction to this drug.

Original languageEnglish
Pages (from-to)7-9
Number of pages3
JournalEuropean Journal of Pharmacology
Volume318
Issue number1
DOIs
Publication statusPublished - 27-12-1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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