Acute unilateral oculomotor nerve palsy associated with anti-GQ1b antibody: A case report

Hiroshi Koga, Hiroyuki Osawa, Kazuya Nokura, Hiroko Yamamoto, Eizo Miyata

Research output: Contribution to journalArticlepeer-review

Abstract

An eighteen-year-old woman visited our hospital because of right ptosis and diplopia one week after suffering from a common cold. Neurological examination solely revealed incomplete right oculomotor nerve palsy. Urinary examination, CBC, serological examination, blood biochemistry, and MRI of the brain showed no abnormalities. After adrenocorticosteroid hormone mini-pulse therapy (methylprednisolone 500 mg/day × 3 days), the right oculomotor nerve palsy rapidly improved and she had full recovery at three months post-treatment. Serum IgG anti-GQ1b antibody was markedly elevated at the onset, and became negative after one month. It was suspected that anti-GQ1b antibody was responsible for the unilateral oculomotor nerve palsy in this case and might be one of the causes of the acute unilateral oculomotor nerve palsy of unknown origin.

Original languageEnglish
Pages (from-to)450-455
Number of pages6
JournalNeuro-Ophthalmology Japan
Volume19
Issue number4
Publication statusPublished - 01-12-2002

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Clinical Neurology

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