Adding coronary computed tomography angiography to invasive coronary angiography improves prediction of cardiac events

Hideki Kawai, Sadako Motoyama, Masayoshi Sarai, Hajime Ito, Hiroshi Takahashi, Hiroto Harigaya, Shino Kan, Junichi Ishii, Hirofumi Anno, Toyoaki Murohara, Yukio Ozaki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND: The additive value of plaque characteristics determined by computed tomography angiography (CTA) in patients undergoing invasive coronary angiography (ICA) has not been established. METHODS AND RESULTS: We studied 676 patients undergoing ICA and CTA within 3 months. The luminal diameter narrowing based on ICA and the presence of high risk plaque (HRP) based on CTA were assessed in all coronary artery segments except for those after or before scheduled treatment. We followed their cardiac events including cardiac death, acute coronary syndrome (ACS), and revascularization for de novo lesions ≥3 months after ICA. The incidence of coronary events was higher in the segments including >25% luminal narrowing than in those without (2.94% vs. 0.31%, P<0.0001), and higher in the segments containing HRP than in those without (12.6 vs. 0.46%, P<0.0001). Greater than 25% residual luminal narrowing and the presence of HRP were identified as independent predictors of cardiac events after risk adjustment for age, gender, and history of ACS (hazard ratio [HR], 3.22; 95% confidence interval [CI]: 1.29-10.76; P=0.0092, HR, 2.64; 95% CI: 1.59-4.35; P=0.0002, respectively). Adding the presence of HRP to a model including age, gender, ACS history, and >25% residual stenosis improved the prediction of cardiac events.

CONCLUSIONS: Assessment of coronary plaque characteristics on CTA improves the prediction of cardiac events in patients undergoing ICA.

Original languageEnglish
Pages (from-to)2735-2740
Number of pages6
JournalCirculation journal : official journal of the Japanese Circulation Society
Volume78
Issue number11
DOIs
Publication statusPublished - 01-01-2014

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Coronary Angiography
Acute Coronary Syndrome
Coronary Vessels
Pathologic Constriction
Computed Tomography Angiography
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kawai, Hideki ; Motoyama, Sadako ; Sarai, Masayoshi ; Ito, Hajime ; Takahashi, Hiroshi ; Harigaya, Hiroto ; Kan, Shino ; Ishii, Junichi ; Anno, Hirofumi ; Murohara, Toyoaki ; Ozaki, Yukio. / Adding coronary computed tomography angiography to invasive coronary angiography improves prediction of cardiac events. In: Circulation journal : official journal of the Japanese Circulation Society. 2014 ; Vol. 78, No. 11. pp. 2735-2740.
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abstract = "BACKGROUND: The additive value of plaque characteristics determined by computed tomography angiography (CTA) in patients undergoing invasive coronary angiography (ICA) has not been established. METHODS AND RESULTS: We studied 676 patients undergoing ICA and CTA within 3 months. The luminal diameter narrowing based on ICA and the presence of high risk plaque (HRP) based on CTA were assessed in all coronary artery segments except for those after or before scheduled treatment. We followed their cardiac events including cardiac death, acute coronary syndrome (ACS), and revascularization for de novo lesions ≥3 months after ICA. The incidence of coronary events was higher in the segments including >25{\%} luminal narrowing than in those without (2.94{\%} vs. 0.31{\%}, P<0.0001), and higher in the segments containing HRP than in those without (12.6 vs. 0.46{\%}, P<0.0001). Greater than 25{\%} residual luminal narrowing and the presence of HRP were identified as independent predictors of cardiac events after risk adjustment for age, gender, and history of ACS (hazard ratio [HR], 3.22; 95{\%} confidence interval [CI]: 1.29-10.76; P=0.0092, HR, 2.64; 95{\%} CI: 1.59-4.35; P=0.0002, respectively). Adding the presence of HRP to a model including age, gender, ACS history, and >25{\%} residual stenosis improved the prediction of cardiac events.CONCLUSIONS: Assessment of coronary plaque characteristics on CTA improves the prediction of cardiac events in patients undergoing ICA.",
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Adding coronary computed tomography angiography to invasive coronary angiography improves prediction of cardiac events. / Kawai, Hideki; Motoyama, Sadako; Sarai, Masayoshi; Ito, Hajime; Takahashi, Hiroshi; Harigaya, Hiroto; Kan, Shino; Ishii, Junichi; Anno, Hirofumi; Murohara, Toyoaki; Ozaki, Yukio.

In: Circulation journal : official journal of the Japanese Circulation Society, Vol. 78, No. 11, 01.01.2014, p. 2735-2740.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Adding coronary computed tomography angiography to invasive coronary angiography improves prediction of cardiac events

AU - Kawai, Hideki

AU - Motoyama, Sadako

AU - Sarai, Masayoshi

AU - Ito, Hajime

AU - Takahashi, Hiroshi

AU - Harigaya, Hiroto

AU - Kan, Shino

AU - Ishii, Junichi

AU - Anno, Hirofumi

AU - Murohara, Toyoaki

AU - Ozaki, Yukio

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BACKGROUND: The additive value of plaque characteristics determined by computed tomography angiography (CTA) in patients undergoing invasive coronary angiography (ICA) has not been established. METHODS AND RESULTS: We studied 676 patients undergoing ICA and CTA within 3 months. The luminal diameter narrowing based on ICA and the presence of high risk plaque (HRP) based on CTA were assessed in all coronary artery segments except for those after or before scheduled treatment. We followed their cardiac events including cardiac death, acute coronary syndrome (ACS), and revascularization for de novo lesions ≥3 months after ICA. The incidence of coronary events was higher in the segments including >25% luminal narrowing than in those without (2.94% vs. 0.31%, P<0.0001), and higher in the segments containing HRP than in those without (12.6 vs. 0.46%, P<0.0001). Greater than 25% residual luminal narrowing and the presence of HRP were identified as independent predictors of cardiac events after risk adjustment for age, gender, and history of ACS (hazard ratio [HR], 3.22; 95% confidence interval [CI]: 1.29-10.76; P=0.0092, HR, 2.64; 95% CI: 1.59-4.35; P=0.0002, respectively). Adding the presence of HRP to a model including age, gender, ACS history, and >25% residual stenosis improved the prediction of cardiac events.CONCLUSIONS: Assessment of coronary plaque characteristics on CTA improves the prediction of cardiac events in patients undergoing ICA.

AB - BACKGROUND: The additive value of plaque characteristics determined by computed tomography angiography (CTA) in patients undergoing invasive coronary angiography (ICA) has not been established. METHODS AND RESULTS: We studied 676 patients undergoing ICA and CTA within 3 months. The luminal diameter narrowing based on ICA and the presence of high risk plaque (HRP) based on CTA were assessed in all coronary artery segments except for those after or before scheduled treatment. We followed their cardiac events including cardiac death, acute coronary syndrome (ACS), and revascularization for de novo lesions ≥3 months after ICA. The incidence of coronary events was higher in the segments including >25% luminal narrowing than in those without (2.94% vs. 0.31%, P<0.0001), and higher in the segments containing HRP than in those without (12.6 vs. 0.46%, P<0.0001). Greater than 25% residual luminal narrowing and the presence of HRP were identified as independent predictors of cardiac events after risk adjustment for age, gender, and history of ACS (hazard ratio [HR], 3.22; 95% confidence interval [CI]: 1.29-10.76; P=0.0092, HR, 2.64; 95% CI: 1.59-4.35; P=0.0002, respectively). Adding the presence of HRP to a model including age, gender, ACS history, and >25% residual stenosis improved the prediction of cardiac events.CONCLUSIONS: Assessment of coronary plaque characteristics on CTA improves the prediction of cardiac events in patients undergoing ICA.

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U2 - 10.1253/circj.CJ-14-0743

DO - 10.1253/circj.CJ-14-0743

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JO - Circulation Journal

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