Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)

Kohmei Ida; Issay Kitabayashi; Tomohiko Taki; Masafumi Taniwaki; Keiko Noro; Masao Yamamoto; Misao Ohki; Yasuhide Hayashi

doi:10.1182/blood.v90.12.4699.4699_4699_4704

Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)

Kohmei Ida, Issay Kitabayashi, Tomohiko Taki, Masafumi Taniwaki, Keiko Noro, Masao Yamamoto, Misao Ohki, Yasuhide Hayashi

Research output: Contribution to journal › Article › peer-review

229 Citations (Scopus)

Abstract

p300, which was originally cloned as a nuclear binding target of the adenovirus E1A oncoprotein, forms a family with cyclic-AMP response element binding protein (CREB)-binding protein (CBP). p300/CBP are considered to be transcriptional coactivators that connect the basal transcriptional machinery to various DNA-binding transcriptional factors. p300/CBP are implicated in both cell differentiation and regulation of cell-cycle. We identify here that the p300 gene is fused to the MLL gene and that in-frame MLL-p300 fusion protein is generated in acute myeloid leukemia (AML) with t(11;22)(q23;q13). These finding suggest that the basis for the leukemogenesis of t(11;22)-AML is the inability of p300 to regulate cell-cycle end cell differentiation after fusion with MLL.

Original language	English
Pages (from-to)	4699-4704
Number of pages	6
Journal	Blood
Volume	90
Issue number	12
DOIs	https://doi.org/10.1182/blood.v90.12.4699.4699_4699_4704
Publication status	Published - 15-12-1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood.v90.12.4699.4699_4699_4704

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title = "Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)",

abstract = "p300, which was originally cloned as a nuclear binding target of the adenovirus E1A oncoprotein, forms a family with cyclic-AMP response element binding protein (CREB)-binding protein (CBP). p300/CBP are considered to be transcriptional coactivators that connect the basal transcriptional machinery to various DNA-binding transcriptional factors. p300/CBP are implicated in both cell differentiation and regulation of cell-cycle. We identify here that the p300 gene is fused to the MLL gene and that in-frame MLL-p300 fusion protein is generated in acute myeloid leukemia (AML) with t(11;22)(q23;q13). These finding suggest that the basis for the leukemogenesis of t(11;22)-AML is the inability of p300 to regulate cell-cycle end cell differentiation after fusion with MLL.",

author = "Kohmei Ida and Issay Kitabayashi and Tomohiko Taki and Masafumi Taniwaki and Keiko Noro and Masao Yamamoto and Misao Ohki and Yasuhide Hayashi",

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T1 - Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)

AU - Ida, Kohmei

AU - Kitabayashi, Issay

AU - Taki, Tomohiko

AU - Taniwaki, Masafumi

AU - Noro, Keiko

AU - Yamamoto, Masao

AU - Ohki, Misao

AU - Hayashi, Yasuhide

PY - 1997/12/15

Y1 - 1997/12/15

N2 - p300, which was originally cloned as a nuclear binding target of the adenovirus E1A oncoprotein, forms a family with cyclic-AMP response element binding protein (CREB)-binding protein (CBP). p300/CBP are considered to be transcriptional coactivators that connect the basal transcriptional machinery to various DNA-binding transcriptional factors. p300/CBP are implicated in both cell differentiation and regulation of cell-cycle. We identify here that the p300 gene is fused to the MLL gene and that in-frame MLL-p300 fusion protein is generated in acute myeloid leukemia (AML) with t(11;22)(q23;q13). These finding suggest that the basis for the leukemogenesis of t(11;22)-AML is the inability of p300 to regulate cell-cycle end cell differentiation after fusion with MLL.

AB - p300, which was originally cloned as a nuclear binding target of the adenovirus E1A oncoprotein, forms a family with cyclic-AMP response element binding protein (CREB)-binding protein (CBP). p300/CBP are considered to be transcriptional coactivators that connect the basal transcriptional machinery to various DNA-binding transcriptional factors. p300/CBP are implicated in both cell differentiation and regulation of cell-cycle. We identify here that the p300 gene is fused to the MLL gene and that in-frame MLL-p300 fusion protein is generated in acute myeloid leukemia (AML) with t(11;22)(q23;q13). These finding suggest that the basis for the leukemogenesis of t(11;22)-AML is the inability of p300 to regulate cell-cycle end cell differentiation after fusion with MLL.

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JF - Blood

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Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)

Abstract

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