Adherence of lyme disease spirochetes to rat lymphocytes

Donato Fumarola; M. Costanza Cedola; Ginevra Guanti; Akihiro Matsuura; Toshimistu Uede; Emilio Jirillo

doi:10.1016/S0176-6724(86)80117-1

Adherence of lyme disease spirochetes to rat lymphocytes

Donato Fumarola, M. Costanza Cedola, Ginevra Guanti, Akihiro Matsuura, Toshimistu Uede, Emilio Jirillo

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In the present work, the capacity of Lyme disease (LD) Spirochetes to spontaneously adhere to rat lymphocytes has been evaluated. Borrelia organisms adhere to thymus, spleen, Payer's patches and peripheral blood lymphocytes in a higher frequency than that observed with Salmonella minnesota R345 (Rb) used as reference strain. Employing enriched splenic T and B cell populations, Spirochete binding to B lymphocytes is more elevated than that obtained with Salmonella, while similar percentage of T cells forms rosettes with both microorganisms. Taken together, these findings provide evidence for a novel mode of interaction between LD Spirochetes and host immune system.

Original language	English
Pages (from-to)	146-150
Number of pages	5
Journal	Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume	263
Issue number	1-2
DOIs	https://doi.org/10.1016/S0176-6724(86)80117-1
Publication status	Published - 1986
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology

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10.1016/S0176-6724(86)80117-1

Cite this

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title = "Adherence of lyme disease spirochetes to rat lymphocytes",

abstract = "In the present work, the capacity of Lyme disease (LD) Spirochetes to spontaneously adhere to rat lymphocytes has been evaluated. Borrelia organisms adhere to thymus, spleen, Payer's patches and peripheral blood lymphocytes in a higher frequency than that observed with Salmonella minnesota R345 (Rb) used as reference strain. Employing enriched splenic T and B cell populations, Spirochete binding to B lymphocytes is more elevated than that obtained with Salmonella, while similar percentage of T cells forms rosettes with both microorganisms. Taken together, these findings provide evidence for a novel mode of interaction between LD Spirochetes and host immune system.",

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T1 - Adherence of lyme disease spirochetes to rat lymphocytes

AU - Fumarola, Donato

AU - Cedola, M. Costanza

AU - Guanti, Ginevra

AU - Matsuura, Akihiro

AU - Uede, Toshimistu

AU - Jirillo, Emilio

PY - 1986

Y1 - 1986

N2 - In the present work, the capacity of Lyme disease (LD) Spirochetes to spontaneously adhere to rat lymphocytes has been evaluated. Borrelia organisms adhere to thymus, spleen, Payer's patches and peripheral blood lymphocytes in a higher frequency than that observed with Salmonella minnesota R345 (Rb) used as reference strain. Employing enriched splenic T and B cell populations, Spirochete binding to B lymphocytes is more elevated than that obtained with Salmonella, while similar percentage of T cells forms rosettes with both microorganisms. Taken together, these findings provide evidence for a novel mode of interaction between LD Spirochetes and host immune system.

AB - In the present work, the capacity of Lyme disease (LD) Spirochetes to spontaneously adhere to rat lymphocytes has been evaluated. Borrelia organisms adhere to thymus, spleen, Payer's patches and peripheral blood lymphocytes in a higher frequency than that observed with Salmonella minnesota R345 (Rb) used as reference strain. Employing enriched splenic T and B cell populations, Spirochete binding to B lymphocytes is more elevated than that obtained with Salmonella, while similar percentage of T cells forms rosettes with both microorganisms. Taken together, these findings provide evidence for a novel mode of interaction between LD Spirochetes and host immune system.

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Adherence of lyme disease spirochetes to rat lymphocytes

Abstract

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