Adherence of lyme disease spirochetes to rat lymphocytes

Donato Fumarola, M. Costanza Cedola, Ginevra Guanti, Akihiro Matsuura, Toshimistu Uede, Emilio Jirillo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In the present work, the capacity of Lyme disease (LD) Spirochetes to spontaneously adhere to rat lymphocytes has been evaluated. Borrelia organisms adhere to thymus, spleen, Payer's patches and peripheral blood lymphocytes in a higher frequency than that observed with Salmonella minnesota R345 (Rb) used as reference strain. Employing enriched splenic T and B cell populations, Spirochete binding to B lymphocytes is more elevated than that obtained with Salmonella, while similar percentage of T cells forms rosettes with both microorganisms. Taken together, these findings provide evidence for a novel mode of interaction between LD Spirochetes and host immune system.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume263
Issue number1-2
DOIs
Publication statusPublished - 01-01-1986

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Borrelia burgdorferi
Salmonella
B-Lymphocytes
Lymphocytes
T-Lymphocytes
Borrelia
Spirochaetales
Thymus Gland
Immune System
Spleen
Population

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Fumarola, Donato ; Cedola, M. Costanza ; Guanti, Ginevra ; Matsuura, Akihiro ; Uede, Toshimistu ; Jirillo, Emilio. / Adherence of lyme disease spirochetes to rat lymphocytes. In: Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A. 1986 ; Vol. 263, No. 1-2. pp. 146-150.
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Adherence of lyme disease spirochetes to rat lymphocytes. / Fumarola, Donato; Cedola, M. Costanza; Guanti, Ginevra; Matsuura, Akihiro; Uede, Toshimistu; Jirillo, Emilio.

In: Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A, Vol. 263, No. 1-2, 01.01.1986, p. 146-150.

Research output: Contribution to journalArticle

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