Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1

Nobuhisa Nakamura, Keiko Naruse, Takashi Matsuki, Yoji Hamada, Eitaro Nakashima, Hideki Kamiya, Tatsuaki Matsubara, Atsushi Enomoto, Masahide Takahashi, Yutaka Oiso, Jiro Nakamura

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38 Citations (Scopus)

Abstract

Adiponectin has anti-atherosclerotic effects through its direct actions on vascular cells. The present study investigates the molecular mechanisms of adiponectin in the migration of endothelial progenitor cells (EPCs) which play an important role in neovascularization and re-endothelization. The phosphorylation of Akt and the activations of Cdc42 and Rac1 were significantly increased by adiponectin. Adiponectin increased the migration activity of EPCs, which was completely inhibited by a PI3-kinase inhibitor. siRNA of Cdc42 or Rac1 completely inhibited the adiponectin-induced migration, but siRNA of Akt had no effects, indicating that adiponectin promotes the migration activities of EPCs mainly through PI3-kinase/Cdc42/Rac1. Structured summary: MINT-7217629: PAK1 (uniprotkb:Q13153) physically interacts (MI:0914) with CDC42 (uniprotkb:P60953) by pull down (MI:0096). MINT-7217644: PAK1 (uniprotkb:Q13153) physically interacts (MI:0914) with Rac1 (uniprotkb:P63000) by pull down (MI:0096).

Original languageEnglish
Pages (from-to)2457-2463
Number of pages7
JournalFEBS Letters
Volume583
Issue number15
DOIs
Publication statusPublished - 06-08-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Nakamura, N., Naruse, K., Matsuki, T., Hamada, Y., Nakashima, E., Kamiya, H., Matsubara, T., Enomoto, A., Takahashi, M., Oiso, Y., & Nakamura, J. (2009). Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1. FEBS Letters, 583(15), 2457-2463. https://doi.org/10.1016/j.febslet.2009.07.011