TY - JOUR
T1 - Adipose-derived stem cell therapy for spinal cord injuries
T2 - Advances, challenges, and future directions
AU - Shimizu, Yusuke
AU - Ntege, Edward Hosea
AU - Takahara, Eisaku
AU - Matsuura, Naoki
AU - Matsuura, Rikako
AU - Kamizato, Kota
AU - Inoue, Yoshikazu
AU - Sowa, Yoshihiro
AU - Sunami, Hiroshi
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/6
Y1 - 2024/6
N2 - Spinal cord injury (SCI) has limited treatment options for regaining function. Adipose-derived stem cells (ADSCs) show promise owing to their ability to differentiate into multiple cell types, promote nerve cell survival, and modulate inflammation. This review explores ADSC therapy for SCI, focusing on its potential for improving function, preclinical and early clinical trial progress, challenges, and future directions. Preclinical studies have demonstrated ADSC transplantation's effectiveness in promoting functional recovery, reducing cavity formation, and enhancing nerve regrowth and myelin repair. To improve ADSC efficacy, strategies including genetic modification and combination with rehabilitation are being explored. Early clinical trials have shown safety and feasibility, with some suggesting motor and sensory function improvements. Challenges remain for clinical translation, including optimizing cell survival and delivery, determining dosing, addressing tumor formation risks, and establishing standardized protocols. Future research should focus on overcoming these challenges and exploring the potential for combining ADSC therapy with other treatments, including rehabilitation and medication.
AB - Spinal cord injury (SCI) has limited treatment options for regaining function. Adipose-derived stem cells (ADSCs) show promise owing to their ability to differentiate into multiple cell types, promote nerve cell survival, and modulate inflammation. This review explores ADSC therapy for SCI, focusing on its potential for improving function, preclinical and early clinical trial progress, challenges, and future directions. Preclinical studies have demonstrated ADSC transplantation's effectiveness in promoting functional recovery, reducing cavity formation, and enhancing nerve regrowth and myelin repair. To improve ADSC efficacy, strategies including genetic modification and combination with rehabilitation are being explored. Early clinical trials have shown safety and feasibility, with some suggesting motor and sensory function improvements. Challenges remain for clinical translation, including optimizing cell survival and delivery, determining dosing, addressing tumor formation risks, and establishing standardized protocols. Future research should focus on overcoming these challenges and exploring the potential for combining ADSC therapy with other treatments, including rehabilitation and medication.
KW - Adipose-derived stem cells
KW - Cell therapy
KW - Functional recovery
KW - Neuroregeneration
KW - Paralysis
KW - Spinal cord injury
UR - http://www.scopus.com/inward/record.url?scp=85199529623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85199529623&partnerID=8YFLogxK
U2 - 10.1016/j.reth.2024.07.007
DO - 10.1016/j.reth.2024.07.007
M3 - Review article
AN - SCOPUS:85199529623
SN - 2352-3204
VL - 26
SP - 508
EP - 519
JO - Regenerative Therapy
JF - Regenerative Therapy
ER -