Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: The miyagi cohort study

M. Kawai, Y. Minami, S. Kuriyama, Masako Kakizaki, Y. Kakugawa, Y. Nishino, T. Ishida, A. Fukao, I. Tsuji, N. Ohuchi

Research output: Contribution to journalArticle

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Abstract

Background: The role of adult weight change in breast cancer (BC) risk is unclear in Japanese women. Methods: A total of 10 106 postmenopausal women aged 40-64 years (the Miyagi Cohort) were followed from 1990 to 2003, and 108 BC cases were identified. Hazard ratios (HRs) were estimated according to body mass index (BMI) at the current age and at the of age 20 years, and weight change since age 20 years. Results: Higher current BMI was associated with an increased risk of BC (P for trend=0.02), whereas higher BMI at the age 20 years was inversely associated with this risk (P for trend=0.002). There was a significant association between weight change since age 20 years and BC risk (P for trend=0.0086). Compared with stable weight, HR was 0.35 for weight loss of 5 kg or more (P for weight loss trend=0.04) and 1.55 for weight gain of 12 kg or more (P for weight gain trend=0.05). Conclusion: Adiposity at younger and current age has differential effects on BC risk among postmenopausal women; weight gain in adulthood being associated with an increased, and weight loss with a decreased risk.

Original languageEnglish
Pages (from-to)1443-1447
Number of pages5
JournalBritish Journal of Cancer
Volume103
Issue number9
DOIs
Publication statusPublished - 26-10-2010

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Adiposity
Cohort Studies
Breast Neoplasms
Weights and Measures
Weight Gain
Weight Loss
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kawai, M. ; Minami, Y. ; Kuriyama, S. ; Kakizaki, Masako ; Kakugawa, Y. ; Nishino, Y. ; Ishida, T. ; Fukao, A. ; Tsuji, I. ; Ohuchi, N. / Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women : The miyagi cohort study. In: British Journal of Cancer. 2010 ; Vol. 103, No. 9. pp. 1443-1447.
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title = "Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: The miyagi cohort study",
abstract = "Background: The role of adult weight change in breast cancer (BC) risk is unclear in Japanese women. Methods: A total of 10 106 postmenopausal women aged 40-64 years (the Miyagi Cohort) were followed from 1990 to 2003, and 108 BC cases were identified. Hazard ratios (HRs) were estimated according to body mass index (BMI) at the current age and at the of age 20 years, and weight change since age 20 years. Results: Higher current BMI was associated with an increased risk of BC (P for trend=0.02), whereas higher BMI at the age 20 years was inversely associated with this risk (P for trend=0.002). There was a significant association between weight change since age 20 years and BC risk (P for trend=0.0086). Compared with stable weight, HR was 0.35 for weight loss of 5 kg or more (P for weight loss trend=0.04) and 1.55 for weight gain of 12 kg or more (P for weight gain trend=0.05). Conclusion: Adiposity at younger and current age has differential effects on BC risk among postmenopausal women; weight gain in adulthood being associated with an increased, and weight loss with a decreased risk.",
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Kawai, M, Minami, Y, Kuriyama, S, Kakizaki, M, Kakugawa, Y, Nishino, Y, Ishida, T, Fukao, A, Tsuji, I & Ohuchi, N 2010, 'Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: The miyagi cohort study', British Journal of Cancer, vol. 103, no. 9, pp. 1443-1447. https://doi.org/10.1038/sj.bjc.6605885

Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women : The miyagi cohort study. / Kawai, M.; Minami, Y.; Kuriyama, S.; Kakizaki, Masako; Kakugawa, Y.; Nishino, Y.; Ishida, T.; Fukao, A.; Tsuji, I.; Ohuchi, N.

In: British Journal of Cancer, Vol. 103, No. 9, 26.10.2010, p. 1443-1447.

Research output: Contribution to journalArticle

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T1 - Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women

T2 - The miyagi cohort study

AU - Kawai, M.

AU - Minami, Y.

AU - Kuriyama, S.

AU - Kakizaki, Masako

AU - Kakugawa, Y.

AU - Nishino, Y.

AU - Ishida, T.

AU - Fukao, A.

AU - Tsuji, I.

AU - Ohuchi, N.

PY - 2010/10/26

Y1 - 2010/10/26

N2 - Background: The role of adult weight change in breast cancer (BC) risk is unclear in Japanese women. Methods: A total of 10 106 postmenopausal women aged 40-64 years (the Miyagi Cohort) were followed from 1990 to 2003, and 108 BC cases were identified. Hazard ratios (HRs) were estimated according to body mass index (BMI) at the current age and at the of age 20 years, and weight change since age 20 years. Results: Higher current BMI was associated with an increased risk of BC (P for trend=0.02), whereas higher BMI at the age 20 years was inversely associated with this risk (P for trend=0.002). There was a significant association between weight change since age 20 years and BC risk (P for trend=0.0086). Compared with stable weight, HR was 0.35 for weight loss of 5 kg or more (P for weight loss trend=0.04) and 1.55 for weight gain of 12 kg or more (P for weight gain trend=0.05). Conclusion: Adiposity at younger and current age has differential effects on BC risk among postmenopausal women; weight gain in adulthood being associated with an increased, and weight loss with a decreased risk.

AB - Background: The role of adult weight change in breast cancer (BC) risk is unclear in Japanese women. Methods: A total of 10 106 postmenopausal women aged 40-64 years (the Miyagi Cohort) were followed from 1990 to 2003, and 108 BC cases were identified. Hazard ratios (HRs) were estimated according to body mass index (BMI) at the current age and at the of age 20 years, and weight change since age 20 years. Results: Higher current BMI was associated with an increased risk of BC (P for trend=0.02), whereas higher BMI at the age 20 years was inversely associated with this risk (P for trend=0.002). There was a significant association between weight change since age 20 years and BC risk (P for trend=0.0086). Compared with stable weight, HR was 0.35 for weight loss of 5 kg or more (P for weight loss trend=0.04) and 1.55 for weight gain of 12 kg or more (P for weight gain trend=0.05). Conclusion: Adiposity at younger and current age has differential effects on BC risk among postmenopausal women; weight gain in adulthood being associated with an increased, and weight loss with a decreased risk.

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