Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury

Hiroaki Asai, Hiroshi Fujiwara, Sohei Kitazawa, Naoto Kobayashi, Toshiki Ochi, Yukihiro Miyazaki, Fumihiro Ochi, Yoshiki Akatsuka, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroaki Ikeda, Hiroshi Shiku, Masaki Yasukawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane.

Original languageEnglish
Article number3
JournalJournal of Hematology and Oncology
Volume7
Issue number1
DOIs
Publication statusPublished - 06-01-2014

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury'. Together they form a unique fingerprint.

  • Cite this

    Asai, H., Fujiwara, H., Kitazawa, S., Kobayashi, N., Ochi, T., Miyazaki, Y., Ochi, F., Akatsuka, Y., Okamoto, S., Mineno, J., Kuzushima, K., Ikeda, H., Shiku, H., & Yasukawa, M. (2014). Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury. Journal of Hematology and Oncology, 7(1), [3]. https://doi.org/10.1186/1756-8722-7-3