TY - JOUR
T1 - Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury
AU - Asai, Hiroaki
AU - Fujiwara, Hiroshi
AU - Kitazawa, Sohei
AU - Kobayashi, Naoto
AU - Ochi, Toshiki
AU - Miyazaki, Yukihiro
AU - Ochi, Fumihiro
AU - Akatsuka, Yoshiki
AU - Okamoto, Sachiko
AU - Mineno, Junichi
AU - Kuzushima, Kiyotaka
AU - Ikeda, Hiroaki
AU - Shiku, Hiroshi
AU - Yasukawa, Masaki
PY - 2014/1/6
Y1 - 2014/1/6
N2 - Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane.
AB - Because WT1 is expressed in leukemia cells, the development of cancer immunotherapy targeting WT1 has been an attractive translational research topic. However, concern of this therapy still remains, since WT1 is abundantly expressed in renal glomerular podocytes. In the present study, we clearly showed that WT1-specific cytotoxic T lymphocytes (CTLs) certainly exerted cytotoxicity against podocytes in vitro; however, they did not damage podocytes in vivo. This might be due to the anatomical localization of podocytes, being structurally separated from circulating CTLs in glomerular capillaries by an exceptionally thick basement membrane.
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U2 - 10.1186/1756-8722-7-3
DO - 10.1186/1756-8722-7-3
M3 - Article
C2 - 24393438
AN - SCOPUS:84891528521
SN - 1756-8722
VL - 7
JO - Journal of Hematology and Oncology
JF - Journal of Hematology and Oncology
IS - 1
M1 - 3
ER -