Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory

Takashi Kitamura, Yoshito Saitoh, Noriko Takashima, Akiko Murayama, Yosuke Niibori, Hiroshi Ageta, Mariko Sekiguchi, Hiroyuki Sugiyama, Kaoru Inokuchi

Research output: Contribution to journalArticle

318 Citations (Scopus)

Abstract

Summary: Acquired memory initially depends on the hippocampus (HPC) for the process of cortical permanent memory formation. The mechanisms through which memory becomes progressively independent from the HPC remain unknown. In the HPC, adult neurogenesis has been described in many mammalian species, even at old ages. Using two mouse models in which hippocampal neurogenesis is physically or genetically suppressed, we show that decreased neurogenesis is accompanied by a prolonged HPC-dependent period of associative fear memory. Inversely, enhanced neurogenesis by voluntary exercise sped up the decay rate of HPC dependency of memory, without loss of memory. Consistently, decreased neurogenesis facilitated the long-lasting maintenance of rat hippocampal long-term potentiation in vivo. These independent lines of evidence strongly suggest that the level of hippocampal neurogenesis play a role in determination of the HPC-dependent period of memory in adult rodents. These observations provide a framework for understanding the mechanisms of the hippocampal-cortical complementary learning systems.

Original languageEnglish
Pages (from-to)814-827
Number of pages14
JournalCell
Volume139
Issue number4
DOIs
Publication statusPublished - 13-11-2009

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Neurogenesis
Fear
Hippocampus
Data storage equipment
Long-Term Potentiation
Memory Disorders
Rodentia
Learning systems
Rats
Maintenance
Learning

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kitamura, T., Saitoh, Y., Takashima, N., Murayama, A., Niibori, Y., Ageta, H., ... Inokuchi, K. (2009). Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory. Cell, 139(4), 814-827. https://doi.org/10.1016/j.cell.2009.10.020
Kitamura, Takashi ; Saitoh, Yoshito ; Takashima, Noriko ; Murayama, Akiko ; Niibori, Yosuke ; Ageta, Hiroshi ; Sekiguchi, Mariko ; Sugiyama, Hiroyuki ; Inokuchi, Kaoru. / Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory. In: Cell. 2009 ; Vol. 139, No. 4. pp. 814-827.
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Kitamura, T, Saitoh, Y, Takashima, N, Murayama, A, Niibori, Y, Ageta, H, Sekiguchi, M, Sugiyama, H & Inokuchi, K 2009, 'Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory', Cell, vol. 139, no. 4, pp. 814-827. https://doi.org/10.1016/j.cell.2009.10.020

Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory. / Kitamura, Takashi; Saitoh, Yoshito; Takashima, Noriko; Murayama, Akiko; Niibori, Yosuke; Ageta, Hiroshi; Sekiguchi, Mariko; Sugiyama, Hiroyuki; Inokuchi, Kaoru.

In: Cell, Vol. 139, No. 4, 13.11.2009, p. 814-827.

Research output: Contribution to journalArticle

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Kitamura T, Saitoh Y, Takashima N, Murayama A, Niibori Y, Ageta H et al. Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory. Cell. 2009 Nov 13;139(4):814-827. https://doi.org/10.1016/j.cell.2009.10.020