Adult-onset Still's Disease complicated by autoimmune hepatitis: Successful treatment with infliximab

Kenji Fujii, Ryo Rokutanda, Yasuhiro Osugi, Yoshinobu Koyama, Toshiyuki Ota

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A 17-year-old woman was previously diagnosed with autoimmune hepatitis (AIH) by liver biopsy. Adultonset Still's disease (AOSD) was subsequently diagnosed on the basis of high fever, arthralgia, erythema, leukocytosis (>80% granulocytes), cervical lymph node swelling, splenomegaly, and hyperferritinemia. Her symptoms and liver dysfunction improved with prednisolone of 60 mg daily and subsequently methotrexate was added. However her symptoms and liver dysfunction relapsed when prednisolone was tapered to 20 mg/ day. Therefore infliximab was introduced additionally and her symptoms and liver dysfunction subsided. To our knowledge, this is the first reported case of AOSD with AIH diagnosed by liver biopsy.

Original languageEnglish
Pages (from-to)1125-1128
Number of pages4
JournalInternal Medicine
Volume51
Issue number9
DOIs
Publication statusPublished - 10-05-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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