TY - JOUR
T1 - Adult-onset Still's Disease complicated by autoimmune hepatitis
T2 - Successful treatment with infliximab
AU - Fujii, Kenji
AU - Rokutanda, Ryo
AU - Osugi, Yasuhiro
AU - Koyama, Yoshinobu
AU - Ota, Toshiyuki
PY - 2012
Y1 - 2012
N2 - A 17-year-old woman was previously diagnosed with autoimmune hepatitis (AIH) by liver biopsy. Adultonset Still's disease (AOSD) was subsequently diagnosed on the basis of high fever, arthralgia, erythema, leukocytosis (>80% granulocytes), cervical lymph node swelling, splenomegaly, and hyperferritinemia. Her symptoms and liver dysfunction improved with prednisolone of 60 mg daily and subsequently methotrexate was added. However her symptoms and liver dysfunction relapsed when prednisolone was tapered to 20 mg/ day. Therefore infliximab was introduced additionally and her symptoms and liver dysfunction subsided. To our knowledge, this is the first reported case of AOSD with AIH diagnosed by liver biopsy.
AB - A 17-year-old woman was previously diagnosed with autoimmune hepatitis (AIH) by liver biopsy. Adultonset Still's disease (AOSD) was subsequently diagnosed on the basis of high fever, arthralgia, erythema, leukocytosis (>80% granulocytes), cervical lymph node swelling, splenomegaly, and hyperferritinemia. Her symptoms and liver dysfunction improved with prednisolone of 60 mg daily and subsequently methotrexate was added. However her symptoms and liver dysfunction relapsed when prednisolone was tapered to 20 mg/ day. Therefore infliximab was introduced additionally and her symptoms and liver dysfunction subsided. To our knowledge, this is the first reported case of AOSD with AIH diagnosed by liver biopsy.
UR - http://www.scopus.com/inward/record.url?scp=84860617237&partnerID=8YFLogxK
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U2 - 10.2169/internalmedicine.51.6824
DO - 10.2169/internalmedicine.51.6824
M3 - Article
C2 - 22576401
AN - SCOPUS:84860617237
SN - 0918-2918
VL - 51
SP - 1125
EP - 1128
JO - Internal Medicine
JF - Internal Medicine
IS - 9
ER -
