Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks

Doyoon Kim; Satoru Morikawa; Taneaki Nakagawa; Hideyuki Okano; Yoshitaka Kase

doi:10.1016/j.expneurol.2025.115177

Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks

Doyoon Kim, Satoru Morikawa, Taneaki Nakagawa, Hideyuki Okano, Yoshitaka Kase

International Center for Brain Science

Research output: Contribution to journal › Article › peer-review

Abstract

The application of existing radical treatments for stroke is limited to a small number of cases, with current practices predominantly focusing on conservative therapy. This review examines the pathophysiology of excitotoxicity, oxidative stress, and inflammation during brain ischemia caused by stroke, highlighting insights into each pathology and reporting the latest therapeutic developments that are expected to serve as new treatment options. Finally, we outline the recent attention given to the relationship between periodontal disease and stroke. We propose addressing the limitations of existing treatments for stroke and suggest novel therapeutic approaches while also presenting the potential contribution of periodontal disease treatment to the prevention of stroke.

Original language	English
Article number	115177
Journal	Experimental Neurology
Volume	386
DOIs	https://doi.org/10.1016/j.expneurol.2025.115177
Publication status	Published - 04-2025

All Science Journal Classification (ASJC) codes

Neurology
Developmental Neuroscience

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10.1016/j.expneurol.2025.115177

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title = "Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks",

abstract = "The application of existing radical treatments for stroke is limited to a small number of cases, with current practices predominantly focusing on conservative therapy. This review examines the pathophysiology of excitotoxicity, oxidative stress, and inflammation during brain ischemia caused by stroke, highlighting insights into each pathology and reporting the latest therapeutic developments that are expected to serve as new treatment options. Finally, we outline the recent attention given to the relationship between periodontal disease and stroke. We propose addressing the limitations of existing treatments for stroke and suggest novel therapeutic approaches while also presenting the potential contribution of periodontal disease treatment to the prevention of stroke.",

keywords = "Inflammation, NMDARs, Oxidative stress, Periodontal disease, Stroke",

author = "Doyoon Kim and Satoru Morikawa and Taneaki Nakagawa and Hideyuki Okano and Yoshitaka Kase",

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doi = "10.1016/j.expneurol.2025.115177",

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AU - Kase, Yoshitaka

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AB - The application of existing radical treatments for stroke is limited to a small number of cases, with current practices predominantly focusing on conservative therapy. This review examines the pathophysiology of excitotoxicity, oxidative stress, and inflammation during brain ischemia caused by stroke, highlighting insights into each pathology and reporting the latest therapeutic developments that are expected to serve as new treatment options. Finally, we outline the recent attention given to the relationship between periodontal disease and stroke. We propose addressing the limitations of existing treatments for stroke and suggest novel therapeutic approaches while also presenting the potential contribution of periodontal disease treatment to the prevention of stroke.

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KW - Oxidative stress

KW - Periodontal disease

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Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks

Abstract

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