Advances in defining signaling networks for the establishment of neuronal polarity

Yasuhiro Funahashi, Takashi Watanabe, Kozo Kaibuchi

Research output: Contribution to journalReview article

Abstract

Neurons are highly polarized cells that have structurally and functionally distinct processes called axons and dendrites. How neurons establish polarity is one of the fundamental questions of neuroscience. In the last decade, significant progress has been made in identifying and understanding the molecular mechanisms responsible for neuronal polarization, primarily through researches conducted on cultured neurons. Advances in phosphoproteomics technologies and molecular tools have enabled comprehensive signal analysis and visualization and manipulation of signaling molecules for analyzing neuronal polarity. Furthermore, advances in gene transfer techniques have revealed the role of extracellular and intracellular signaling molecules in neuronal polarization in vivo. This review discusses the latest insights and techniques for the elucidation of the molecular mechanisms that control neuronal polarity.

Original languageEnglish
Pages (from-to)76-87
Number of pages12
JournalCurrent Opinion in Cell Biology
Volume63
DOIs
Publication statusPublished - 04-2020

All Science Journal Classification (ASJC) codes

  • Cell Biology

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