Age-related changes in surface antigens on peripheral lymphocytes of healthy children

Y. Osugi, J. Hara, Hiroki Kurahashi, N. Sakata, M. Inoue, K. Yumura-Yagi, K. Kawa-Ha, S. Okada, A. Tawa

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Abstract

The age-related changes in proportion of various subsets within lymphocytes were investigated in cord blood and peripheral blood from healthy children and adults. The percentages of T and B cells did not show age-related changes, whereas natural killer (NK) cells increased significantly with age. Within lymphocytes or the CD3+ T cell population the proportion of CD45RA(bright+) lymphocytes decreased and that of CD45RO+ cells increased, while that of CD45RA(dim+) cells showed no age-related change. Within lymphocytes, the percentage of CD45RA(bright+) CD4+ cells decreased, together with a decline of that of CD4+ cells. The proportions of CD45RA(bright+) CD8+ cells and S6F1(bright+) CD8+ cells increased with age, and the age-dependent increase of the proportion of CD8+ cells seems to be mainly attributable to the increases in these subsets. The CD45RA(dim+) CD4+ and CD45RA(dim+) CD8+ cells co-expressing CD45RO at a low level nevertheless showed no age-related changes. In γδ T cells, both δTCS1+ and δCS1- T cells increased with age, but the δTCS1- γδ T cells increased more than the δTCS1+ subset. Among lymphocytes, the percentages of CD20+, CD21+ and CD22+ cells remained similar, with no age-related changes, but the proportion of CD5+ cells within lymphocytes or B cells decreased. The proportions of CD16+ NK cells among lymphocytes increased with age, and this change was attributable to the increase of CD56+ cells.

Original languageEnglish
Pages (from-to)543-548
Number of pages6
JournalClinical and Experimental Immunology
Volume100
Issue number3
Publication statusPublished - 01-01-1995
Externally publishedYes

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Surface Antigens
Lymphocytes
T-Lymphocytes
Natural Killer Cells
B-Lymphocytes
Lymphocyte Subsets
Fetal Blood

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Osugi, Y., Hara, J., Kurahashi, H., Sakata, N., Inoue, M., Yumura-Yagi, K., ... Tawa, A. (1995). Age-related changes in surface antigens on peripheral lymphocytes of healthy children. Clinical and Experimental Immunology, 100(3), 543-548.
Osugi, Y. ; Hara, J. ; Kurahashi, Hiroki ; Sakata, N. ; Inoue, M. ; Yumura-Yagi, K. ; Kawa-Ha, K. ; Okada, S. ; Tawa, A. / Age-related changes in surface antigens on peripheral lymphocytes of healthy children. In: Clinical and Experimental Immunology. 1995 ; Vol. 100, No. 3. pp. 543-548.
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Osugi, Y, Hara, J, Kurahashi, H, Sakata, N, Inoue, M, Yumura-Yagi, K, Kawa-Ha, K, Okada, S & Tawa, A 1995, 'Age-related changes in surface antigens on peripheral lymphocytes of healthy children', Clinical and Experimental Immunology, vol. 100, no. 3, pp. 543-548.

Age-related changes in surface antigens on peripheral lymphocytes of healthy children. / Osugi, Y.; Hara, J.; Kurahashi, Hiroki; Sakata, N.; Inoue, M.; Yumura-Yagi, K.; Kawa-Ha, K.; Okada, S.; Tawa, A.

In: Clinical and Experimental Immunology, Vol. 100, No. 3, 01.01.1995, p. 543-548.

Research output: Contribution to journalArticle

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AU - Osugi, Y.

AU - Hara, J.

AU - Kurahashi, Hiroki

AU - Sakata, N.

AU - Inoue, M.

AU - Yumura-Yagi, K.

AU - Kawa-Ha, K.

AU - Okada, S.

AU - Tawa, A.

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Y1 - 1995/1/1

N2 - The age-related changes in proportion of various subsets within lymphocytes were investigated in cord blood and peripheral blood from healthy children and adults. The percentages of T and B cells did not show age-related changes, whereas natural killer (NK) cells increased significantly with age. Within lymphocytes or the CD3+ T cell population the proportion of CD45RA(bright+) lymphocytes decreased and that of CD45RO+ cells increased, while that of CD45RA(dim+) cells showed no age-related change. Within lymphocytes, the percentage of CD45RA(bright+) CD4+ cells decreased, together with a decline of that of CD4+ cells. The proportions of CD45RA(bright+) CD8+ cells and S6F1(bright+) CD8+ cells increased with age, and the age-dependent increase of the proportion of CD8+ cells seems to be mainly attributable to the increases in these subsets. The CD45RA(dim+) CD4+ and CD45RA(dim+) CD8+ cells co-expressing CD45RO at a low level nevertheless showed no age-related changes. In γδ T cells, both δTCS1+ and δCS1- T cells increased with age, but the δTCS1- γδ T cells increased more than the δTCS1+ subset. Among lymphocytes, the percentages of CD20+, CD21+ and CD22+ cells remained similar, with no age-related changes, but the proportion of CD5+ cells within lymphocytes or B cells decreased. The proportions of CD16+ NK cells among lymphocytes increased with age, and this change was attributable to the increase of CD56+ cells.

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