Age-related changes in surface antigens on peripheral lymphocytes of healthy children

Y. Osugi, J. Hara, H. Kurahashi, N. Sakata, M. Inoue, K. Yumura-Yagi, K. Kawa-Ha, S. Okada, A. Tawa

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49 Citations (Scopus)


The age-related changes in proportion of various subsets within lymphocytes were investigated in cord blood and peripheral blood from healthy children and adults. The percentages of T and B cells did not show age-related changes, whereas natural killer (NK) cells increased significantly with age. Within lymphocytes or the CD3+ T cell population the proportion of CD45RA(bright+) lymphocytes decreased and that of CD45RO+ cells increased, while that of CD45RA(dim+) cells showed no age-related change. Within lymphocytes, the percentage of CD45RA(bright+) CD4+ cells decreased, together with a decline of that of CD4+ cells. The proportions of CD45RA(bright+) CD8+ cells and S6F1(bright+) CD8+ cells increased with age, and the age-dependent increase of the proportion of CD8+ cells seems to be mainly attributable to the increases in these subsets. The CD45RA(dim+) CD4+ and CD45RA(dim+) CD8+ cells co-expressing CD45RO at a low level nevertheless showed no age-related changes. In γδ T cells, both δTCS1+ and δCS1- T cells increased with age, but the δTCS1- γδ T cells increased more than the δTCS1+ subset. Among lymphocytes, the percentages of CD20+, CD21+ and CD22+ cells remained similar, with no age-related changes, but the proportion of CD5+ cells within lymphocytes or B cells decreased. The proportions of CD16+ NK cells among lymphocytes increased with age, and this change was attributable to the increase of CD56+ cells.

Original languageEnglish
Pages (from-to)543-548
Number of pages6
JournalClinical and Experimental Immunology
Issue number3
Publication statusPublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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