TY - JOUR
T1 - Age-related impairment in Addenbrooke’s cognitive examination revised scores in patients with amyotrophic lateral sclerosis
AU - Masuda, Michihito
AU - Watanabe, Hirohisa
AU - Tanaka, Yasuhiro
AU - Ohdake, Reiko
AU - Ogura, Aya
AU - Yokoi, Takamasa
AU - Imai, Kazunori
AU - Kawabata, Kazuya
AU - Riku, Yuichi
AU - Hara, Kazuhiro
AU - Nakamura, Ryoichi
AU - Atsuta, Naoki
AU - Katsuno, Masahisa
AU - Sobue, Gen
N1 - Funding Information:
This study was partially supported by a Grant-in-Aid from the Research Committee of Central Nervous System Degenerative Diseases by the Ministry of Health, Labor, and Welfare, Integrated Research on Neuropsychiatric Disorders project carried out Strategic Research Program for Brain Sciences (SRPBS), a Grant-in-Aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control 26117002) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, as well as Integrated Research on neuropsychiatric disorders carried out under the SRPBS, Scientific Research on Innovative Areas (Comprehensive Brain Science Network), and Integrated Research on Depression, Dementia and Development Disorders by SRPBS from Japan Agency for Medical Research and development.
Publisher Copyright:
© 2018, © 2018 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases.
PY - 2018/10/2
Y1 - 2018/10/2
N2 - Objective: Older age is thought to be a risk factor for cognitive impairment in amyotrophic lateral sclerosis (ALS). However, very few clinical studies have investigated this relationship using sufficient numbers of healthy controls that correspond to each generation. The purpose of this study was to determine the age-related changes of Addenbrooke’s Cognitive Examination-Revised (ACE-R) score in ALS patients by comparing healthy controls of various ages. Methods: 131 ALS patients (86 males, 45 females; mean age: 64.8 ± 10.2; mean education: 12.5 ± 2.7) and 151 age-, gender-, and education-matched healthy controls were enrolled. We applied ACE-R, which could evaluate not only global cognition but five cognitive subdomains that included orientation/attention, memory, verbal fluency, language, and visuospatial ability. Results: ALS patients had significantly lower total and subdomain scores of ACE-R than healthy controls. Multiple regression analysis suggested that age at examination and age at onset had significant influence on ACE-R scores. When we divided ALS patients and healthy controls into 4 groups according to age at examination for ALS, total and each subdomain scores were significantly lower with age, particularly in the older-middle and the oldest group (66.31 years or more) of ALS compared with healthy controls. Locally weighted scatterplot smoothing analysis supported that these reductions of ACE-R total and subdomain scores in ALS patients were more accelerated by approximately 60 years as compared with healthy controls. Conclusion: ALS patients showed accelerated age-related ACE-R score reduction beyond normal ageing processes.
AB - Objective: Older age is thought to be a risk factor for cognitive impairment in amyotrophic lateral sclerosis (ALS). However, very few clinical studies have investigated this relationship using sufficient numbers of healthy controls that correspond to each generation. The purpose of this study was to determine the age-related changes of Addenbrooke’s Cognitive Examination-Revised (ACE-R) score in ALS patients by comparing healthy controls of various ages. Methods: 131 ALS patients (86 males, 45 females; mean age: 64.8 ± 10.2; mean education: 12.5 ± 2.7) and 151 age-, gender-, and education-matched healthy controls were enrolled. We applied ACE-R, which could evaluate not only global cognition but five cognitive subdomains that included orientation/attention, memory, verbal fluency, language, and visuospatial ability. Results: ALS patients had significantly lower total and subdomain scores of ACE-R than healthy controls. Multiple regression analysis suggested that age at examination and age at onset had significant influence on ACE-R scores. When we divided ALS patients and healthy controls into 4 groups according to age at examination for ALS, total and each subdomain scores were significantly lower with age, particularly in the older-middle and the oldest group (66.31 years or more) of ALS compared with healthy controls. Locally weighted scatterplot smoothing analysis supported that these reductions of ACE-R total and subdomain scores in ALS patients were more accelerated by approximately 60 years as compared with healthy controls. Conclusion: ALS patients showed accelerated age-related ACE-R score reduction beyond normal ageing processes.
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U2 - 10.1080/21678421.2018.1510009
DO - 10.1080/21678421.2018.1510009
M3 - Article
C2 - 30379106
AN - SCOPUS:85055860937
VL - 19
SP - 578
EP - 584
JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
SN - 2167-8421
IS - 7-8
ER -