Age-related neointimal hyperplasia is associated with monocyte infiltration after balloon angioplasty

Sammy D.D. Eghbalieh, Paraag Chowdhary, Akihito Muto, Kenneth R. Ziegler, Fabio A. Kudo, Jose M. Pimiento, Issa Mirmehdi, Lynn S. Model, Yuka Kondo, Toshiya Nishibe, Alan Dardik

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Carotid angioplasty is associated with adverse events in elderly patients; it is unclear whether this is related to an altered inflammatory axis. The carotid arteries of young (6 months) or aged (22-24 months) Fischer 344 rats were balloon injured. Aged rats had reduced lumen area (0.18 ± 0.03 vs 0.24 ± 0.01 mm 2, p =. 02) and increased neointimal thickening (0.15 ± 0.04 vs 0.08 ± 0.03 mm 2, p =. 006). Aged rats had increased circulating monocytes (96 ± 21 vs. 54 ± 7; p =. 002) as well as increased numbers of monocytes at the post-angioplasty site. Aged rats had sustained monocyte chemotactic protein-1 expression after angioplasty but young rats did not. Aged arteries also exhibited defective vasorelaxation and abnormal eNOS localization. Aged (≥80 years) human patients with high-grade carotid stenosis had increased number of monocytes (9.1% ± 0.4%) compared with younger (65-80 years) patients (8.1% ± 0.3%, p =. 013). Aged rats develop neointimal hyperplasia after carotid angioplasty with increased numbers of monocytes, and elderly humans with carotid stenosis have increased numbers of circulating monocytes. These preliminary results may suggest a role for monocytes in the response to carotid angioplasty.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67 A
Issue number2
DOIs
Publication statusPublished - 02-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

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