TY - JOUR
T1 - Age-related neointimal hyperplasia is associated with monocyte infiltration after balloon angioplasty
AU - Eghbalieh, Sammy D.D.
AU - Chowdhary, Paraag
AU - Muto, Akihito
AU - Ziegler, Kenneth R.
AU - Kudo, Fabio A.
AU - Pimiento, Jose M.
AU - Mirmehdi, Issa
AU - Model, Lynn S.
AU - Kondo, Yuka
AU - Nishibe, Toshiya
AU - Dardik, Alan
PY - 2012/2
Y1 - 2012/2
N2 - Carotid angioplasty is associated with adverse events in elderly patients; it is unclear whether this is related to an altered inflammatory axis. The carotid arteries of young (6 months) or aged (22-24 months) Fischer 344 rats were balloon injured. Aged rats had reduced lumen area (0.18 ± 0.03 vs 0.24 ± 0.01 mm 2, p =. 02) and increased neointimal thickening (0.15 ± 0.04 vs 0.08 ± 0.03 mm 2, p =. 006). Aged rats had increased circulating monocytes (96 ± 21 vs. 54 ± 7; p =. 002) as well as increased numbers of monocytes at the post-angioplasty site. Aged rats had sustained monocyte chemotactic protein-1 expression after angioplasty but young rats did not. Aged arteries also exhibited defective vasorelaxation and abnormal eNOS localization. Aged (≥80 years) human patients with high-grade carotid stenosis had increased number of monocytes (9.1% ± 0.4%) compared with younger (65-80 years) patients (8.1% ± 0.3%, p =. 013). Aged rats develop neointimal hyperplasia after carotid angioplasty with increased numbers of monocytes, and elderly humans with carotid stenosis have increased numbers of circulating monocytes. These preliminary results may suggest a role for monocytes in the response to carotid angioplasty.
AB - Carotid angioplasty is associated with adverse events in elderly patients; it is unclear whether this is related to an altered inflammatory axis. The carotid arteries of young (6 months) or aged (22-24 months) Fischer 344 rats were balloon injured. Aged rats had reduced lumen area (0.18 ± 0.03 vs 0.24 ± 0.01 mm 2, p =. 02) and increased neointimal thickening (0.15 ± 0.04 vs 0.08 ± 0.03 mm 2, p =. 006). Aged rats had increased circulating monocytes (96 ± 21 vs. 54 ± 7; p =. 002) as well as increased numbers of monocytes at the post-angioplasty site. Aged rats had sustained monocyte chemotactic protein-1 expression after angioplasty but young rats did not. Aged arteries also exhibited defective vasorelaxation and abnormal eNOS localization. Aged (≥80 years) human patients with high-grade carotid stenosis had increased number of monocytes (9.1% ± 0.4%) compared with younger (65-80 years) patients (8.1% ± 0.3%, p =. 013). Aged rats develop neointimal hyperplasia after carotid angioplasty with increased numbers of monocytes, and elderly humans with carotid stenosis have increased numbers of circulating monocytes. These preliminary results may suggest a role for monocytes in the response to carotid angioplasty.
UR - https://www.scopus.com/pages/publications/84856206761
UR - https://www.scopus.com/pages/publications/84856206761#tab=citedBy
U2 - 10.1093/gerona/glr190
DO - 10.1093/gerona/glr190
M3 - Article
C2 - 22016364
AN - SCOPUS:84856206761
SN - 1079-5006
VL - 67 A
SP - 109
EP - 117
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 2
ER -