Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN)

the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN)

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods: A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results: During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62; 95% confidence interval [CI], 1.35-1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13; 95% CI, 1.47-3.09) and stroke (HR 1.40; 95% CI, 1.05-1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions: The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalJournal of epidemiology
Volume27
Issue number3
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Diabetes Mellitus
Japan
Cardiovascular Diseases
Mortality
Research
Coronary Disease
Stroke
Confidence Intervals
Proportional Hazards Models
Population
Cohort Studies
Age Groups

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

@article{1a492dc2d393414398911d8b25af284b,
title = "Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN)",
abstract = "Background: Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods: A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results: During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62; 95{\%} confidence interval [CI], 1.35-1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13; 95{\%} CI, 1.47-3.09) and stroke (HR 1.40; 95{\%} CI, 1.05-1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions: The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population.",
author = "{the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN)} and Yoichiro Hirakawa and Toshiharu Ninomiya and Yutaka Kiyohara and Yoshitaka Murakami and Shigeyuki Saitoh and Hideaki Nakagawa and Akira Okayama and Akiko Tamakoshi and Kiyomi Sakata and Katsuyuki Miura and Hirotsugu Ueshima and Tomonori Okamura and Yutaka Imai and Takayoshi Ohkubo and Fujiko Irie and Hiroyasu Iso and Akihiko Kitamura and Takeo Nakayama and Toshimi Sairenchi and Ichiro Tsuji and Michiko Yamada and Masahiko Kiyama and Yoshihiro Miyamoto and Shizukiyo Ishikawa and Hiroshi Yatsuya",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.je.2016.04.001",
language = "English",
volume = "27",
pages = "123--129",
journal = "Journal of Epidemiology",
issn = "0917-5040",
publisher = "Japan Epidemiology Association",
number = "3",

}

Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality : An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN). / the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN).

In: Journal of epidemiology, Vol. 27, No. 3, 01.01.2017, p. 123-129.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality

T2 - An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN)

AU - the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN)

AU - Hirakawa, Yoichiro

AU - Ninomiya, Toshiharu

AU - Kiyohara, Yutaka

AU - Murakami, Yoshitaka

AU - Saitoh, Shigeyuki

AU - Nakagawa, Hideaki

AU - Okayama, Akira

AU - Tamakoshi, Akiko

AU - Sakata, Kiyomi

AU - Miura, Katsuyuki

AU - Ueshima, Hirotsugu

AU - Okamura, Tomonori

AU - Imai, Yutaka

AU - Ohkubo, Takayoshi

AU - Irie, Fujiko

AU - Iso, Hiroyasu

AU - Kitamura, Akihiko

AU - Nakayama, Takeo

AU - Sairenchi, Toshimi

AU - Tsuji, Ichiro

AU - Yamada, Michiko

AU - Kiyama, Masahiko

AU - Miyamoto, Yoshihiro

AU - Ishikawa, Shizukiyo

AU - Yatsuya, Hiroshi

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods: A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results: During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62; 95% confidence interval [CI], 1.35-1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13; 95% CI, 1.47-3.09) and stroke (HR 1.40; 95% CI, 1.05-1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions: The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population.

AB - Background: Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods: A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results: During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62; 95% confidence interval [CI], 1.35-1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13; 95% CI, 1.47-3.09) and stroke (HR 1.40; 95% CI, 1.05-1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions: The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=85017085566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017085566&partnerID=8YFLogxK

U2 - 10.1016/j.je.2016.04.001

DO - 10.1016/j.je.2016.04.001

M3 - Article

C2 - 28142033

AN - SCOPUS:85017085566

VL - 27

SP - 123

EP - 129

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 3

ER -