Aggregation of stomach cancer history in parents and offspring in comparison with other sites

Takaaki Kondo, Hideaki Toyoshima, Yoshie Tsuzuki, Yoko Hori, Hiroshi Yatsuya, Koji Tamakoshi, Akiko Tamakoshi, Yoshiyuki Ohno, Shogo Kikuchi, Kiyoshi Sakata, Yoshiharu Hoshiyama, Norihiko Hayakawa, Noritaki Tokui, Tetsuya Mizoue, Takesumi Yoshimura

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background. The aim of this study is to evaluate the magnitude of the aggregation of a stomach cancer history in parents and their offspring in comparison with that of a history at other sites. Methods. We used the baseline data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study), which was initiated during 1988-1990 in Japan. Association of the cancer history of the subjects' parents with that of the subjects themselves and any of the subjects' siblings was evaluated with odds ratios (OR) by the crude and generalized estimating equations (GEE) technique for four sites: stomach, colorectum, liver, and lung/bronchus. Results. The aggregation of a history of stomach cancer between parents and their offspring was evident with significant OR >2.5. The magnitude of the parent-offspring association of a disease history of the colorectum and liver was found to be greater than that for stomach cancer. Conversely, lung and bronchus cancer failed to demonstrate a significant aggregation. Conclusions. The hereditary and environmental influences shared by parents and offspring are likely to play a strong aetiological role in colorectal or liver cancer versus a weaker but still significant role in stomach cancer. In contrast, the aetiological role of familial predisposition to lung cancer was indeterminate, which suggests a predominant role of non-familial factors in the development of lung cancer.

Original languageEnglish
Pages (from-to)579-583
Number of pages5
JournalInternational Journal of Epidemiology
Volume32
Issue number4
DOIs
Publication statusPublished - 01-08-2003

Fingerprint

Stomach Neoplasms
Lung Neoplasms
Bronchi
Japan
Odds Ratio
Liver
Liver Neoplasms
Colorectal Neoplasms
Neoplasms
Stomach
Cohort Studies
History
Lung

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Kondo, Takaaki ; Toyoshima, Hideaki ; Tsuzuki, Yoshie ; Hori, Yoko ; Yatsuya, Hiroshi ; Tamakoshi, Koji ; Tamakoshi, Akiko ; Ohno, Yoshiyuki ; Kikuchi, Shogo ; Sakata, Kiyoshi ; Hoshiyama, Yoshiharu ; Hayakawa, Norihiko ; Tokui, Noritaki ; Mizoue, Tetsuya ; Yoshimura, Takesumi. / Aggregation of stomach cancer history in parents and offspring in comparison with other sites. In: International Journal of Epidemiology. 2003 ; Vol. 32, No. 4. pp. 579-583.
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title = "Aggregation of stomach cancer history in parents and offspring in comparison with other sites",
abstract = "Background. The aim of this study is to evaluate the magnitude of the aggregation of a stomach cancer history in parents and their offspring in comparison with that of a history at other sites. Methods. We used the baseline data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study), which was initiated during 1988-1990 in Japan. Association of the cancer history of the subjects' parents with that of the subjects themselves and any of the subjects' siblings was evaluated with odds ratios (OR) by the crude and generalized estimating equations (GEE) technique for four sites: stomach, colorectum, liver, and lung/bronchus. Results. The aggregation of a history of stomach cancer between parents and their offspring was evident with significant OR >2.5. The magnitude of the parent-offspring association of a disease history of the colorectum and liver was found to be greater than that for stomach cancer. Conversely, lung and bronchus cancer failed to demonstrate a significant aggregation. Conclusions. The hereditary and environmental influences shared by parents and offspring are likely to play a strong aetiological role in colorectal or liver cancer versus a weaker but still significant role in stomach cancer. In contrast, the aetiological role of familial predisposition to lung cancer was indeterminate, which suggests a predominant role of non-familial factors in the development of lung cancer.",
author = "Takaaki Kondo and Hideaki Toyoshima and Yoshie Tsuzuki and Yoko Hori and Hiroshi Yatsuya and Koji Tamakoshi and Akiko Tamakoshi and Yoshiyuki Ohno and Shogo Kikuchi and Kiyoshi Sakata and Yoshiharu Hoshiyama and Norihiko Hayakawa and Noritaki Tokui and Tetsuya Mizoue and Takesumi Yoshimura",
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Kondo, T, Toyoshima, H, Tsuzuki, Y, Hori, Y, Yatsuya, H, Tamakoshi, K, Tamakoshi, A, Ohno, Y, Kikuchi, S, Sakata, K, Hoshiyama, Y, Hayakawa, N, Tokui, N, Mizoue, T & Yoshimura, T 2003, 'Aggregation of stomach cancer history in parents and offspring in comparison with other sites', International Journal of Epidemiology, vol. 32, no. 4, pp. 579-583. https://doi.org/10.1093/ije/dyg152

Aggregation of stomach cancer history in parents and offspring in comparison with other sites. / Kondo, Takaaki; Toyoshima, Hideaki; Tsuzuki, Yoshie; Hori, Yoko; Yatsuya, Hiroshi; Tamakoshi, Koji; Tamakoshi, Akiko; Ohno, Yoshiyuki; Kikuchi, Shogo; Sakata, Kiyoshi; Hoshiyama, Yoshiharu; Hayakawa, Norihiko; Tokui, Noritaki; Mizoue, Tetsuya; Yoshimura, Takesumi.

In: International Journal of Epidemiology, Vol. 32, No. 4, 01.08.2003, p. 579-583.

Research output: Contribution to journalArticle

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T1 - Aggregation of stomach cancer history in parents and offspring in comparison with other sites

AU - Kondo, Takaaki

AU - Toyoshima, Hideaki

AU - Tsuzuki, Yoshie

AU - Hori, Yoko

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Koji

AU - Tamakoshi, Akiko

AU - Ohno, Yoshiyuki

AU - Kikuchi, Shogo

AU - Sakata, Kiyoshi

AU - Hoshiyama, Yoshiharu

AU - Hayakawa, Norihiko

AU - Tokui, Noritaki

AU - Mizoue, Tetsuya

AU - Yoshimura, Takesumi

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Background. The aim of this study is to evaluate the magnitude of the aggregation of a stomach cancer history in parents and their offspring in comparison with that of a history at other sites. Methods. We used the baseline data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study), which was initiated during 1988-1990 in Japan. Association of the cancer history of the subjects' parents with that of the subjects themselves and any of the subjects' siblings was evaluated with odds ratios (OR) by the crude and generalized estimating equations (GEE) technique for four sites: stomach, colorectum, liver, and lung/bronchus. Results. The aggregation of a history of stomach cancer between parents and their offspring was evident with significant OR >2.5. The magnitude of the parent-offspring association of a disease history of the colorectum and liver was found to be greater than that for stomach cancer. Conversely, lung and bronchus cancer failed to demonstrate a significant aggregation. Conclusions. The hereditary and environmental influences shared by parents and offspring are likely to play a strong aetiological role in colorectal or liver cancer versus a weaker but still significant role in stomach cancer. In contrast, the aetiological role of familial predisposition to lung cancer was indeterminate, which suggests a predominant role of non-familial factors in the development of lung cancer.

AB - Background. The aim of this study is to evaluate the magnitude of the aggregation of a stomach cancer history in parents and their offspring in comparison with that of a history at other sites. Methods. We used the baseline data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study), which was initiated during 1988-1990 in Japan. Association of the cancer history of the subjects' parents with that of the subjects themselves and any of the subjects' siblings was evaluated with odds ratios (OR) by the crude and generalized estimating equations (GEE) technique for four sites: stomach, colorectum, liver, and lung/bronchus. Results. The aggregation of a history of stomach cancer between parents and their offspring was evident with significant OR >2.5. The magnitude of the parent-offspring association of a disease history of the colorectum and liver was found to be greater than that for stomach cancer. Conversely, lung and bronchus cancer failed to demonstrate a significant aggregation. Conclusions. The hereditary and environmental influences shared by parents and offspring are likely to play a strong aetiological role in colorectal or liver cancer versus a weaker but still significant role in stomach cancer. In contrast, the aetiological role of familial predisposition to lung cancer was indeterminate, which suggests a predominant role of non-familial factors in the development of lung cancer.

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