TY - JOUR
T1 - Airway involvement in inflammatory bowel disease
T2 - Inflammatory bowel disease patients have bronchial wall thickening
AU - Majima, Suguru
AU - Wakahara, Keiko
AU - Iwano, Shingo
AU - Kinoshita, Fumie
AU - Nakamura, Masanao
AU - Hashimoto, Naozumi
AU - Fujishiro, Mitsuhiro
AU - Hasegawa, Yoshinori
N1 - Publisher Copyright:
© 2022 The Japanese Respiratory Society
PY - 2022/9
Y1 - 2022/9
N2 - Background: Recent epidemiological studies have revealed a high co-occurrence of asthma or COPD and IBD. Herein, we examined the impact of IBD on the bronchial wall structure using three-dimensional computed tomography (3D-CT). Methods: Subjects who were diagnosed with IBD and had undergone chest CT were recruited from consecutive medical records. Screening chest CT scan data during the same period were used as normal controls. Airway dimensions were measured by validated software. Results: Overall, 136 IBD and 99 control subjects were recruited. The bronchial walls of patients with IBD were significantly thicker than those of control subjects. Multiple linear regression analysis showed that Crohn's disease and ulcerative colitis were independent determinants of wall area percentage after adjusting for age, sex, and smoking status. Conclusions: Airway walls in patients with IBD were thicker than those in normal control subjects. Airway involvement in IBD may be more frequent than recognized.
AB - Background: Recent epidemiological studies have revealed a high co-occurrence of asthma or COPD and IBD. Herein, we examined the impact of IBD on the bronchial wall structure using three-dimensional computed tomography (3D-CT). Methods: Subjects who were diagnosed with IBD and had undergone chest CT were recruited from consecutive medical records. Screening chest CT scan data during the same period were used as normal controls. Airway dimensions were measured by validated software. Results: Overall, 136 IBD and 99 control subjects were recruited. The bronchial walls of patients with IBD were significantly thicker than those of control subjects. Multiple linear regression analysis showed that Crohn's disease and ulcerative colitis were independent determinants of wall area percentage after adjusting for age, sex, and smoking status. Conclusions: Airway walls in patients with IBD were thicker than those in normal control subjects. Airway involvement in IBD may be more frequent than recognized.
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U2 - 10.1016/j.resinv.2022.06.003
DO - 10.1016/j.resinv.2022.06.003
M3 - Article
C2 - 35821190
AN - SCOPUS:85133664702
SN - 2212-5345
VL - 60
SP - 713
EP - 719
JO - Respiratory Investigation
JF - Respiratory Investigation
IS - 5
ER -