Alcohol consumption and breast cancer risk in Japanese women: The Miyagi Cohort Study

Masaaki Kawai, Yuko Minami, Masako Kakizaki, Yoichiro Kakugawa, Yoshikazu Nishino, Akira Fukao, Ichiro Tsuji, Noriaki Ohuchi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Alcohol consumption is known to be a risk factor for breast cancer in Western countries, but few epidemiologic data have been available in Japan. This population-based prospective cohort study evaluated the associations of alcohol consumption with breast cancer risk in a Japanese population. A total of 19,227 women aged 40-64 years were followed from 1990 to 2003. During 246,703 person-years of follow-up, 241 breast cancer cases were identified. Hazard ratios (HRs) were estimated by the Cox proportional-hazard regression model. After adjustment for potential risk factors of breast cancer and nutritional factors, the HR and 95% confidence interval (CI) for current drinkers was 1.00 (0.74-1.34) compared with never drinkers. According to the amount of alcohol intake per day, a higher amount (∼15.0 g/day) had no significant relation to breast cancer risk (HR = 0.87, 95% CI: 0.40-1.91; P for trend = 0.85). Age upon starting to drink, and the frequency of drinking, were not associated with breast cancer risk. In analysis stratified according to exogenous female hormone use, a higher alcohol intake (∼15.0 g/day) was associated with an increased risk of breast cancer among hormone users (HR = 1.67, 95% CI: 0.17-16.73); however, this was not statistically significant. Stratification according to folate intake with energy adjustment (<219, ∼219 μg/day) found that breast cancer risk tended to increase with increasing alcohol consumption among women with a low intake of folate (P for trend = 0.09). Our findings suggest that alcohol consumption has no overall effect on breast cancer risk among Japanese women, whereas nutritional factors such as folate intake may modify the alcohol-breast cancer risk relationship.

Original languageEnglish
Pages (from-to)817-825
Number of pages9
JournalBreast Cancer Research and Treatment
Volume128
Issue number3
DOIs
Publication statusPublished - 01-08-2011

Fingerprint

Alcohol Drinking
Cohort Studies
Breast Neoplasms
Folic Acid
Alcohols
Confidence Intervals
Hormones
Social Adjustment
Energy Intake
Proportional Hazards Models
Population
Drinking
Japan
Odds Ratio
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kawai, Masaaki ; Minami, Yuko ; Kakizaki, Masako ; Kakugawa, Yoichiro ; Nishino, Yoshikazu ; Fukao, Akira ; Tsuji, Ichiro ; Ohuchi, Noriaki. / Alcohol consumption and breast cancer risk in Japanese women : The Miyagi Cohort Study. In: Breast Cancer Research and Treatment. 2011 ; Vol. 128, No. 3. pp. 817-825.
@article{4e7c695f56134062bd4b49e549ee9bd6,
title = "Alcohol consumption and breast cancer risk in Japanese women: The Miyagi Cohort Study",
abstract = "Alcohol consumption is known to be a risk factor for breast cancer in Western countries, but few epidemiologic data have been available in Japan. This population-based prospective cohort study evaluated the associations of alcohol consumption with breast cancer risk in a Japanese population. A total of 19,227 women aged 40-64 years were followed from 1990 to 2003. During 246,703 person-years of follow-up, 241 breast cancer cases were identified. Hazard ratios (HRs) were estimated by the Cox proportional-hazard regression model. After adjustment for potential risk factors of breast cancer and nutritional factors, the HR and 95{\%} confidence interval (CI) for current drinkers was 1.00 (0.74-1.34) compared with never drinkers. According to the amount of alcohol intake per day, a higher amount (∼15.0 g/day) had no significant relation to breast cancer risk (HR = 0.87, 95{\%} CI: 0.40-1.91; P for trend = 0.85). Age upon starting to drink, and the frequency of drinking, were not associated with breast cancer risk. In analysis stratified according to exogenous female hormone use, a higher alcohol intake (∼15.0 g/day) was associated with an increased risk of breast cancer among hormone users (HR = 1.67, 95{\%} CI: 0.17-16.73); however, this was not statistically significant. Stratification according to folate intake with energy adjustment (<219, ∼219 μg/day) found that breast cancer risk tended to increase with increasing alcohol consumption among women with a low intake of folate (P for trend = 0.09). Our findings suggest that alcohol consumption has no overall effect on breast cancer risk among Japanese women, whereas nutritional factors such as folate intake may modify the alcohol-breast cancer risk relationship.",
author = "Masaaki Kawai and Yuko Minami and Masako Kakizaki and Yoichiro Kakugawa and Yoshikazu Nishino and Akira Fukao and Ichiro Tsuji and Noriaki Ohuchi",
year = "2011",
month = "8",
day = "1",
doi = "10.1007/s10549-011-1381-x",
language = "English",
volume = "128",
pages = "817--825",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "3",

}

Kawai, M, Minami, Y, Kakizaki, M, Kakugawa, Y, Nishino, Y, Fukao, A, Tsuji, I & Ohuchi, N 2011, 'Alcohol consumption and breast cancer risk in Japanese women: The Miyagi Cohort Study', Breast Cancer Research and Treatment, vol. 128, no. 3, pp. 817-825. https://doi.org/10.1007/s10549-011-1381-x

Alcohol consumption and breast cancer risk in Japanese women : The Miyagi Cohort Study. / Kawai, Masaaki; Minami, Yuko; Kakizaki, Masako; Kakugawa, Yoichiro; Nishino, Yoshikazu; Fukao, Akira; Tsuji, Ichiro; Ohuchi, Noriaki.

In: Breast Cancer Research and Treatment, Vol. 128, No. 3, 01.08.2011, p. 817-825.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alcohol consumption and breast cancer risk in Japanese women

T2 - The Miyagi Cohort Study

AU - Kawai, Masaaki

AU - Minami, Yuko

AU - Kakizaki, Masako

AU - Kakugawa, Yoichiro

AU - Nishino, Yoshikazu

AU - Fukao, Akira

AU - Tsuji, Ichiro

AU - Ohuchi, Noriaki

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Alcohol consumption is known to be a risk factor for breast cancer in Western countries, but few epidemiologic data have been available in Japan. This population-based prospective cohort study evaluated the associations of alcohol consumption with breast cancer risk in a Japanese population. A total of 19,227 women aged 40-64 years were followed from 1990 to 2003. During 246,703 person-years of follow-up, 241 breast cancer cases were identified. Hazard ratios (HRs) were estimated by the Cox proportional-hazard regression model. After adjustment for potential risk factors of breast cancer and nutritional factors, the HR and 95% confidence interval (CI) for current drinkers was 1.00 (0.74-1.34) compared with never drinkers. According to the amount of alcohol intake per day, a higher amount (∼15.0 g/day) had no significant relation to breast cancer risk (HR = 0.87, 95% CI: 0.40-1.91; P for trend = 0.85). Age upon starting to drink, and the frequency of drinking, were not associated with breast cancer risk. In analysis stratified according to exogenous female hormone use, a higher alcohol intake (∼15.0 g/day) was associated with an increased risk of breast cancer among hormone users (HR = 1.67, 95% CI: 0.17-16.73); however, this was not statistically significant. Stratification according to folate intake with energy adjustment (<219, ∼219 μg/day) found that breast cancer risk tended to increase with increasing alcohol consumption among women with a low intake of folate (P for trend = 0.09). Our findings suggest that alcohol consumption has no overall effect on breast cancer risk among Japanese women, whereas nutritional factors such as folate intake may modify the alcohol-breast cancer risk relationship.

AB - Alcohol consumption is known to be a risk factor for breast cancer in Western countries, but few epidemiologic data have been available in Japan. This population-based prospective cohort study evaluated the associations of alcohol consumption with breast cancer risk in a Japanese population. A total of 19,227 women aged 40-64 years were followed from 1990 to 2003. During 246,703 person-years of follow-up, 241 breast cancer cases were identified. Hazard ratios (HRs) were estimated by the Cox proportional-hazard regression model. After adjustment for potential risk factors of breast cancer and nutritional factors, the HR and 95% confidence interval (CI) for current drinkers was 1.00 (0.74-1.34) compared with never drinkers. According to the amount of alcohol intake per day, a higher amount (∼15.0 g/day) had no significant relation to breast cancer risk (HR = 0.87, 95% CI: 0.40-1.91; P for trend = 0.85). Age upon starting to drink, and the frequency of drinking, were not associated with breast cancer risk. In analysis stratified according to exogenous female hormone use, a higher alcohol intake (∼15.0 g/day) was associated with an increased risk of breast cancer among hormone users (HR = 1.67, 95% CI: 0.17-16.73); however, this was not statistically significant. Stratification according to folate intake with energy adjustment (<219, ∼219 μg/day) found that breast cancer risk tended to increase with increasing alcohol consumption among women with a low intake of folate (P for trend = 0.09). Our findings suggest that alcohol consumption has no overall effect on breast cancer risk among Japanese women, whereas nutritional factors such as folate intake may modify the alcohol-breast cancer risk relationship.

UR - http://www.scopus.com/inward/record.url?scp=79960844795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960844795&partnerID=8YFLogxK

U2 - 10.1007/s10549-011-1381-x

DO - 10.1007/s10549-011-1381-x

M3 - Article

C2 - 21318600

AN - SCOPUS:79960844795

VL - 128

SP - 817

EP - 825

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 3

ER -