Alcohol consumption and colorectal cancer risk: Findings from the JACC Study

Kenji Wakai, Masayo Kojima, Koji Tamakoshi, Yoshiyuki Watanabe, Norihiko Hayakawa, Koji Suzuki, Shuji Hashimoto, Miyuki Kawado, Shinkan Tokudome, Sadao Suzuki, Kotaro Ozasa, Hideaki Toyoshima, Yoshinori Ito, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo MikamiYutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Because alcohol drinking is a potential risk factor for colorectal cancer, the trend in alcohol consumption in Japan may partly explain the increase in incidence and mortality rates of this malignancy until 1990-1995. Methods: We analyzed data from the Japan Collaborative Cohort Study. From 1988 to 1990, 23,708 men and 34,028 women, aged 40-79 years, completed a questionnaire on lifestyle factors including drinking habits. Incidence rate ratios (IRR) were estimated by using proportional hazards models. Results: During the mean follow-up of 7.6 years through December 1997, we documented 418 incidents of colon cancer and 211 of rectal cancer. Male ex- or current drinkers demonstrated a twofold risk for colon cancer compared with nondrinkers: the multivariate-adjusted IRR was 2.01 (95% confidence interval [CI] 1.09-3.68) for ex-drinkers and 1.97 (95% Cl: 1.28-3.03) for current drinkers. The dose-response relationship between alcohol consumption and the risk, however, was not clear. Female ex-drinkers were at an increased risk without statistical significance. For rectal cancer, we found a slightly lower risk in light current drinkers who consumed less than 22 g ethanol per day: the multivariate IRR was 0.61 (95% Cl: 0.33-1.13) for men and 0.69 (95% Cl: 0.27-1.74) for women. Although the IRR for all current drinkers was almost unity in men, an increasing trend in risk was detected with increasing alcohol consumption in current drinkers (trend p = 0.027). Conclusions: Taking the findings from our study and other prospective investigations into consideration, more attention should be paid to alcohol consumption in the prevention of colon cancer in Japan.

Original languageEnglish
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 14-10-2005

Fingerprint

Alcohol Drinking
Colorectal Neoplasms
Colonic Neoplasms
Incidence
Japan
Rectal Neoplasms
Proportional Hazards Models
Drinking
Habits
Life Style
Cohort Studies
Ethanol
Prospective Studies
Confidence Intervals
Mortality
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Wakai, K., Kojima, M., Tamakoshi, K., Watanabe, Y., Hayakawa, N., Suzuki, K., ... Tajima, K. (2005). Alcohol consumption and colorectal cancer risk: Findings from the JACC Study. Journal of epidemiology, 15(SUPPL. 2). https://doi.org/10.2188/jea.15.S173
Wakai, Kenji ; Kojima, Masayo ; Tamakoshi, Koji ; Watanabe, Yoshiyuki ; Hayakawa, Norihiko ; Suzuki, Koji ; Hashimoto, Shuji ; Kawado, Miyuki ; Tokudome, Shinkan ; Suzuki, Sadao ; Ozasa, Kotaro ; Toyoshima, Hideaki ; Ito, Yoshinori ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / Alcohol consumption and colorectal cancer risk : Findings from the JACC Study. In: Journal of epidemiology. 2005 ; Vol. 15, No. SUPPL. 2.
@article{4ffb25a26767438ca667c094d4e5c413,
title = "Alcohol consumption and colorectal cancer risk: Findings from the JACC Study",
abstract = "Background: Because alcohol drinking is a potential risk factor for colorectal cancer, the trend in alcohol consumption in Japan may partly explain the increase in incidence and mortality rates of this malignancy until 1990-1995. Methods: We analyzed data from the Japan Collaborative Cohort Study. From 1988 to 1990, 23,708 men and 34,028 women, aged 40-79 years, completed a questionnaire on lifestyle factors including drinking habits. Incidence rate ratios (IRR) were estimated by using proportional hazards models. Results: During the mean follow-up of 7.6 years through December 1997, we documented 418 incidents of colon cancer and 211 of rectal cancer. Male ex- or current drinkers demonstrated a twofold risk for colon cancer compared with nondrinkers: the multivariate-adjusted IRR was 2.01 (95{\%} confidence interval [CI] 1.09-3.68) for ex-drinkers and 1.97 (95{\%} Cl: 1.28-3.03) for current drinkers. The dose-response relationship between alcohol consumption and the risk, however, was not clear. Female ex-drinkers were at an increased risk without statistical significance. For rectal cancer, we found a slightly lower risk in light current drinkers who consumed less than 22 g ethanol per day: the multivariate IRR was 0.61 (95{\%} Cl: 0.33-1.13) for men and 0.69 (95{\%} Cl: 0.27-1.74) for women. Although the IRR for all current drinkers was almost unity in men, an increasing trend in risk was detected with increasing alcohol consumption in current drinkers (trend p = 0.027). Conclusions: Taking the findings from our study and other prospective investigations into consideration, more attention should be paid to alcohol consumption in the prevention of colon cancer in Japan.",
author = "Kenji Wakai and Masayo Kojima and Koji Tamakoshi and Yoshiyuki Watanabe and Norihiko Hayakawa and Koji Suzuki and Shuji Hashimoto and Miyuki Kawado and Shinkan Tokudome and Sadao Suzuki and Kotaro Ozasa and Hideaki Toyoshima and Yoshinori Ito and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
year = "2005",
month = "10",
day = "14",
doi = "10.2188/jea.15.S173",
language = "English",
volume = "15",
journal = "Journal of Epidemiology",
issn = "0917-5040",
publisher = "Japan Epidemiology Association",
number = "SUPPL. 2",

}

Wakai, K, Kojima, M, Tamakoshi, K, Watanabe, Y, Hayakawa, N, Suzuki, K, Hashimoto, S, Kawado, M, Tokudome, S, Suzuki, S, Ozasa, K, Toyoshima, H, Ito, Y, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Kikuchi, S, Koizumi, A, Kawamura, T, Miki, T, Date, C, Sakata, K, Nose, T, Yoshimura, T, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T & Tajima, K 2005, 'Alcohol consumption and colorectal cancer risk: Findings from the JACC Study', Journal of epidemiology, vol. 15, no. SUPPL. 2. https://doi.org/10.2188/jea.15.S173

Alcohol consumption and colorectal cancer risk : Findings from the JACC Study. / Wakai, Kenji; Kojima, Masayo; Tamakoshi, Koji; Watanabe, Yoshiyuki; Hayakawa, Norihiko; Suzuki, Koji; Hashimoto, Shuji; Kawado, Miyuki; Tokudome, Shinkan; Suzuki, Sadao; Ozasa, Kotaro; Toyoshima, Hideaki; Ito, Yoshinori; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

In: Journal of epidemiology, Vol. 15, No. SUPPL. 2, 14.10.2005.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alcohol consumption and colorectal cancer risk

T2 - Findings from the JACC Study

AU - Wakai, Kenji

AU - Kojima, Masayo

AU - Tamakoshi, Koji

AU - Watanabe, Yoshiyuki

AU - Hayakawa, Norihiko

AU - Suzuki, Koji

AU - Hashimoto, Shuji

AU - Kawado, Miyuki

AU - Tokudome, Shinkan

AU - Suzuki, Sadao

AU - Ozasa, Kotaro

AU - Toyoshima, Hideaki

AU - Ito, Yoshinori

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2005/10/14

Y1 - 2005/10/14

N2 - Background: Because alcohol drinking is a potential risk factor for colorectal cancer, the trend in alcohol consumption in Japan may partly explain the increase in incidence and mortality rates of this malignancy until 1990-1995. Methods: We analyzed data from the Japan Collaborative Cohort Study. From 1988 to 1990, 23,708 men and 34,028 women, aged 40-79 years, completed a questionnaire on lifestyle factors including drinking habits. Incidence rate ratios (IRR) were estimated by using proportional hazards models. Results: During the mean follow-up of 7.6 years through December 1997, we documented 418 incidents of colon cancer and 211 of rectal cancer. Male ex- or current drinkers demonstrated a twofold risk for colon cancer compared with nondrinkers: the multivariate-adjusted IRR was 2.01 (95% confidence interval [CI] 1.09-3.68) for ex-drinkers and 1.97 (95% Cl: 1.28-3.03) for current drinkers. The dose-response relationship between alcohol consumption and the risk, however, was not clear. Female ex-drinkers were at an increased risk without statistical significance. For rectal cancer, we found a slightly lower risk in light current drinkers who consumed less than 22 g ethanol per day: the multivariate IRR was 0.61 (95% Cl: 0.33-1.13) for men and 0.69 (95% Cl: 0.27-1.74) for women. Although the IRR for all current drinkers was almost unity in men, an increasing trend in risk was detected with increasing alcohol consumption in current drinkers (trend p = 0.027). Conclusions: Taking the findings from our study and other prospective investigations into consideration, more attention should be paid to alcohol consumption in the prevention of colon cancer in Japan.

AB - Background: Because alcohol drinking is a potential risk factor for colorectal cancer, the trend in alcohol consumption in Japan may partly explain the increase in incidence and mortality rates of this malignancy until 1990-1995. Methods: We analyzed data from the Japan Collaborative Cohort Study. From 1988 to 1990, 23,708 men and 34,028 women, aged 40-79 years, completed a questionnaire on lifestyle factors including drinking habits. Incidence rate ratios (IRR) were estimated by using proportional hazards models. Results: During the mean follow-up of 7.6 years through December 1997, we documented 418 incidents of colon cancer and 211 of rectal cancer. Male ex- or current drinkers demonstrated a twofold risk for colon cancer compared with nondrinkers: the multivariate-adjusted IRR was 2.01 (95% confidence interval [CI] 1.09-3.68) for ex-drinkers and 1.97 (95% Cl: 1.28-3.03) for current drinkers. The dose-response relationship between alcohol consumption and the risk, however, was not clear. Female ex-drinkers were at an increased risk without statistical significance. For rectal cancer, we found a slightly lower risk in light current drinkers who consumed less than 22 g ethanol per day: the multivariate IRR was 0.61 (95% Cl: 0.33-1.13) for men and 0.69 (95% Cl: 0.27-1.74) for women. Although the IRR for all current drinkers was almost unity in men, an increasing trend in risk was detected with increasing alcohol consumption in current drinkers (trend p = 0.027). Conclusions: Taking the findings from our study and other prospective investigations into consideration, more attention should be paid to alcohol consumption in the prevention of colon cancer in Japan.

UR - http://www.scopus.com/inward/record.url?scp=26244443522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26244443522&partnerID=8YFLogxK

U2 - 10.2188/jea.15.S173

DO - 10.2188/jea.15.S173

M3 - Article

C2 - 16127230

AN - SCOPUS:26244443522

VL - 15

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - SUPPL. 2

ER -