TY - JOUR
T1 - Alcohol consumption and risk of stroke and coronary heart disease among Japanese women
T2 - The Japan Public Health Center-based prospective study
AU - Ikehara, Satoyo
AU - Iso, Hiroyasu
AU - Yamagishi, Kazumasa
AU - Kokubo, Yoshihiro
AU - Saito, Isao
AU - Yatsuya, Hiroshi
AU - Inoue, Manami
AU - Tsugane, Shoichiro
N1 - Funding Information:
This study was supported by National Cancer Center Research and Development Fund , a Grant-in-Aid for Cancer Research , a Grant-in-Aid for the Third-Term Comprehensive Ten-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan and Strategic Funds for the Promotion of Science and Technology Program to Improve Preventive Medicine by Analysis of Cohort Data Linked to Medical Records . The authors thank all staff members in each study area and in the central office for their substantial efforts to conduct the baseline survey and follow-up.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/11
Y1 - 2013/11
N2 - Objective: The study aims to examine the association between a wide range of alcohol consumption and risk of stroke and coronary heart disease. Methods: The Japan Public Health Center-based prospective study was initiated in 1990 in Cohort I and in 1993 in Cohort II, with follow-up until 2009. The sample consisted of 47,100 women aged 40-69. years. Results: During an average of 16.7-years, the incidence of 1846 strokes and 292 coronary heart diseases was observed. Heavy drinking (≥ 300. g. ethanol/week) was associated with increased risk of total stroke. The multivariable hazard ratios for heavy versus occasional drinkers were 2.19 (95% confidence interval: 1.45-3.30) for total stroke, 2.25 (1.29-3.91) for hemorrhagic stroke, 2.24 (1.05-4.76) for intraparenchymal hemorrhage, 2.26 (1.01-5.09) for subarachnoid hemorrhage and 2.04 (1.09-3.82) for ischemic stroke. In the exposure-updated analysis, the positive association between heavy drinking and risks of total stroke, hemorrhagic stroke and intraparenchymal hemorrhage became more evident. Light drinking (< 150. g. ethanol/week) was not associated with risk of ischemic stroke. There was also no association between alcohol consumption and risk of coronary heart disease. Conclusion: Heavy drinking was associated with increased risk of hemorrhagic and ischemic strokes among Japanese women.
AB - Objective: The study aims to examine the association between a wide range of alcohol consumption and risk of stroke and coronary heart disease. Methods: The Japan Public Health Center-based prospective study was initiated in 1990 in Cohort I and in 1993 in Cohort II, with follow-up until 2009. The sample consisted of 47,100 women aged 40-69. years. Results: During an average of 16.7-years, the incidence of 1846 strokes and 292 coronary heart diseases was observed. Heavy drinking (≥ 300. g. ethanol/week) was associated with increased risk of total stroke. The multivariable hazard ratios for heavy versus occasional drinkers were 2.19 (95% confidence interval: 1.45-3.30) for total stroke, 2.25 (1.29-3.91) for hemorrhagic stroke, 2.24 (1.05-4.76) for intraparenchymal hemorrhage, 2.26 (1.01-5.09) for subarachnoid hemorrhage and 2.04 (1.09-3.82) for ischemic stroke. In the exposure-updated analysis, the positive association between heavy drinking and risks of total stroke, hemorrhagic stroke and intraparenchymal hemorrhage became more evident. Light drinking (< 150. g. ethanol/week) was not associated with risk of ischemic stroke. There was also no association between alcohol consumption and risk of coronary heart disease. Conclusion: Heavy drinking was associated with increased risk of hemorrhagic and ischemic strokes among Japanese women.
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U2 - 10.1016/j.ypmed.2013.07.003
DO - 10.1016/j.ypmed.2013.07.003
M3 - Article
C2 - 23859928
AN - SCOPUS:84885842869
SN - 0091-7435
VL - 57
SP - 505
EP - 510
JO - Preventive Medicine
JF - Preventive Medicine
IS - 5
ER -
