Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: The Japan Public Health Center-based prospective study

Satoyo Ikehara, Hiroyasu Iso, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Manami Inoue, Shoichiro Tsugane

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: The study aims to examine the association between a wide range of alcohol consumption and risk of stroke and coronary heart disease. Methods: The Japan Public Health Center-based prospective study was initiated in 1990 in Cohort I and in 1993 in Cohort II, with follow-up until 2009. The sample consisted of 47,100 women aged 40-69. years. Results: During an average of 16.7-years, the incidence of 1846 strokes and 292 coronary heart diseases was observed. Heavy drinking (≥ 300. g. ethanol/week) was associated with increased risk of total stroke. The multivariable hazard ratios for heavy versus occasional drinkers were 2.19 (95% confidence interval: 1.45-3.30) for total stroke, 2.25 (1.29-3.91) for hemorrhagic stroke, 2.24 (1.05-4.76) for intraparenchymal hemorrhage, 2.26 (1.01-5.09) for subarachnoid hemorrhage and 2.04 (1.09-3.82) for ischemic stroke. In the exposure-updated analysis, the positive association between heavy drinking and risks of total stroke, hemorrhagic stroke and intraparenchymal hemorrhage became more evident. Light drinking (< 150. g. ethanol/week) was not associated with risk of ischemic stroke. There was also no association between alcohol consumption and risk of coronary heart disease. Conclusion: Heavy drinking was associated with increased risk of hemorrhagic and ischemic strokes among Japanese women.

Original languageEnglish
Pages (from-to)505-510
Number of pages6
JournalPreventive Medicine
Volume57
Issue number5
DOIs
Publication statusPublished - 01-11-2013

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Alcohol Drinking
Coronary Disease
Japan
Public Health
Stroke
Prospective Studies
Drinking
Ethanol
Hemorrhage
Subarachnoid Hemorrhage
Confidence Intervals
Light
Incidence

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Ikehara, Satoyo ; Iso, Hiroyasu ; Yamagishi, Kazumasa ; Kokubo, Yoshihiro ; Saito, Isao ; Yatsuya, Hiroshi ; Inoue, Manami ; Tsugane, Shoichiro. / Alcohol consumption and risk of stroke and coronary heart disease among Japanese women : The Japan Public Health Center-based prospective study. In: Preventive Medicine. 2013 ; Vol. 57, No. 5. pp. 505-510.
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abstract = "Objective: The study aims to examine the association between a wide range of alcohol consumption and risk of stroke and coronary heart disease. Methods: The Japan Public Health Center-based prospective study was initiated in 1990 in Cohort I and in 1993 in Cohort II, with follow-up until 2009. The sample consisted of 47,100 women aged 40-69. years. Results: During an average of 16.7-years, the incidence of 1846 strokes and 292 coronary heart diseases was observed. Heavy drinking (≥ 300. g. ethanol/week) was associated with increased risk of total stroke. The multivariable hazard ratios for heavy versus occasional drinkers were 2.19 (95{\%} confidence interval: 1.45-3.30) for total stroke, 2.25 (1.29-3.91) for hemorrhagic stroke, 2.24 (1.05-4.76) for intraparenchymal hemorrhage, 2.26 (1.01-5.09) for subarachnoid hemorrhage and 2.04 (1.09-3.82) for ischemic stroke. In the exposure-updated analysis, the positive association between heavy drinking and risks of total stroke, hemorrhagic stroke and intraparenchymal hemorrhage became more evident. Light drinking (< 150. g. ethanol/week) was not associated with risk of ischemic stroke. There was also no association between alcohol consumption and risk of coronary heart disease. Conclusion: Heavy drinking was associated with increased risk of hemorrhagic and ischemic strokes among Japanese women.",
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Alcohol consumption and risk of stroke and coronary heart disease among Japanese women : The Japan Public Health Center-based prospective study. / Ikehara, Satoyo; Iso, Hiroyasu; Yamagishi, Kazumasa; Kokubo, Yoshihiro; Saito, Isao; Yatsuya, Hiroshi; Inoue, Manami; Tsugane, Shoichiro.

In: Preventive Medicine, Vol. 57, No. 5, 01.11.2013, p. 505-510.

Research output: Contribution to journalArticle

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T1 - Alcohol consumption and risk of stroke and coronary heart disease among Japanese women

T2 - The Japan Public Health Center-based prospective study

AU - Ikehara, Satoyo

AU - Iso, Hiroyasu

AU - Yamagishi, Kazumasa

AU - Kokubo, Yoshihiro

AU - Saito, Isao

AU - Yatsuya, Hiroshi

AU - Inoue, Manami

AU - Tsugane, Shoichiro

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N2 - Objective: The study aims to examine the association between a wide range of alcohol consumption and risk of stroke and coronary heart disease. Methods: The Japan Public Health Center-based prospective study was initiated in 1990 in Cohort I and in 1993 in Cohort II, with follow-up until 2009. The sample consisted of 47,100 women aged 40-69. years. Results: During an average of 16.7-years, the incidence of 1846 strokes and 292 coronary heart diseases was observed. Heavy drinking (≥ 300. g. ethanol/week) was associated with increased risk of total stroke. The multivariable hazard ratios for heavy versus occasional drinkers were 2.19 (95% confidence interval: 1.45-3.30) for total stroke, 2.25 (1.29-3.91) for hemorrhagic stroke, 2.24 (1.05-4.76) for intraparenchymal hemorrhage, 2.26 (1.01-5.09) for subarachnoid hemorrhage and 2.04 (1.09-3.82) for ischemic stroke. In the exposure-updated analysis, the positive association between heavy drinking and risks of total stroke, hemorrhagic stroke and intraparenchymal hemorrhage became more evident. Light drinking (< 150. g. ethanol/week) was not associated with risk of ischemic stroke. There was also no association between alcohol consumption and risk of coronary heart disease. Conclusion: Heavy drinking was associated with increased risk of hemorrhagic and ischemic strokes among Japanese women.

AB - Objective: The study aims to examine the association between a wide range of alcohol consumption and risk of stroke and coronary heart disease. Methods: The Japan Public Health Center-based prospective study was initiated in 1990 in Cohort I and in 1993 in Cohort II, with follow-up until 2009. The sample consisted of 47,100 women aged 40-69. years. Results: During an average of 16.7-years, the incidence of 1846 strokes and 292 coronary heart diseases was observed. Heavy drinking (≥ 300. g. ethanol/week) was associated with increased risk of total stroke. The multivariable hazard ratios for heavy versus occasional drinkers were 2.19 (95% confidence interval: 1.45-3.30) for total stroke, 2.25 (1.29-3.91) for hemorrhagic stroke, 2.24 (1.05-4.76) for intraparenchymal hemorrhage, 2.26 (1.01-5.09) for subarachnoid hemorrhage and 2.04 (1.09-3.82) for ischemic stroke. In the exposure-updated analysis, the positive association between heavy drinking and risks of total stroke, hemorrhagic stroke and intraparenchymal hemorrhage became more evident. Light drinking (< 150. g. ethanol/week) was not associated with risk of ischemic stroke. There was also no association between alcohol consumption and risk of coronary heart disease. Conclusion: Heavy drinking was associated with increased risk of hemorrhagic and ischemic strokes among Japanese women.

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