Alcohol intake and future incidence of hypertension in a general Japanese population

The Hisayama study

Susumu Ohmori, Yutaka Kiyohara, Isao Kato, Michiaki Kubo, Yumihiro Tanizaki, Hiromitsu Iwamoto, Keizo Nakayama, Isao Abe, Masatoshi Fujishima

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: The question remains as to whether light to moderate alcohol intake is associated with an increased risk of hypertension. Methods: In 1978, a total of 1101 residents (433 men and 668 women) in a subrural community, Hisayama, in Japan, aged 40 years or more, with normal blood pressure, who were free from cardiovascular disease, were enrolled in a 10-year follow-up study. Inquiries regarding regular drinking were made in an interview based on a self-administered questionnaire. Results: During the follow-up, 101 men and 166 women developed hypertension (blood pressure ≥140/90 mm Hg or use of antihypertensive drugs). The age-adjusted incidence of hypertension among current male drinkers increased significantly even with a light intake of alcohol (<23 g of ethanol per day). In women, the incidence was also significantly higher in drinkers than in nondrinkers. In multivariate analysis, alcohol intake, in addition to age and body mass index, remained a significant independent risk factor for hypertension in men, but not in women. In men, all three categories of current drinking were found to be significant risk factors for the development of hypertension after adjustment for age and body mass index [relative risk (RR), 2.00; 95% confidence interval (CI), 1.07-3.76 for light drinking compared with nondrinking; RR, 2.60; 95% CI, 1.50-4.49 for moderate drinking (23-45 g per day); and RR, 2.24; 95% CI, 1.26-3.99 for heavy drinking (≥46 g/day)]. Conclusions: Our results suggest that alcohol intake, even light drinking, is a predictor of future hypertension among Japanese men.

Original languageEnglish
Pages (from-to)1010-1016
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume26
Issue number7
DOIs
Publication statusPublished - 01-01-2002
Externally publishedYes

Fingerprint

Drinking
Alcohols
Hypertension
Incidence
Population
Light
Blood pressure
Confidence Intervals
Body Mass Index
Blood Pressure
Antihypertensive Agents
Japan
Ethanol
Cardiovascular Diseases
Multivariate Analysis
Interviews

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Ohmori, Susumu ; Kiyohara, Yutaka ; Kato, Isao ; Kubo, Michiaki ; Tanizaki, Yumihiro ; Iwamoto, Hiromitsu ; Nakayama, Keizo ; Abe, Isao ; Fujishima, Masatoshi. / Alcohol intake and future incidence of hypertension in a general Japanese population : The Hisayama study. In: Alcoholism: Clinical and Experimental Research. 2002 ; Vol. 26, No. 7. pp. 1010-1016.
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abstract = "Background: The question remains as to whether light to moderate alcohol intake is associated with an increased risk of hypertension. Methods: In 1978, a total of 1101 residents (433 men and 668 women) in a subrural community, Hisayama, in Japan, aged 40 years or more, with normal blood pressure, who were free from cardiovascular disease, were enrolled in a 10-year follow-up study. Inquiries regarding regular drinking were made in an interview based on a self-administered questionnaire. Results: During the follow-up, 101 men and 166 women developed hypertension (blood pressure ≥140/90 mm Hg or use of antihypertensive drugs). The age-adjusted incidence of hypertension among current male drinkers increased significantly even with a light intake of alcohol (<23 g of ethanol per day). In women, the incidence was also significantly higher in drinkers than in nondrinkers. In multivariate analysis, alcohol intake, in addition to age and body mass index, remained a significant independent risk factor for hypertension in men, but not in women. In men, all three categories of current drinking were found to be significant risk factors for the development of hypertension after adjustment for age and body mass index [relative risk (RR), 2.00; 95{\%} confidence interval (CI), 1.07-3.76 for light drinking compared with nondrinking; RR, 2.60; 95{\%} CI, 1.50-4.49 for moderate drinking (23-45 g per day); and RR, 2.24; 95{\%} CI, 1.26-3.99 for heavy drinking (≥46 g/day)]. Conclusions: Our results suggest that alcohol intake, even light drinking, is a predictor of future hypertension among Japanese men.",
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Alcohol intake and future incidence of hypertension in a general Japanese population : The Hisayama study. / Ohmori, Susumu; Kiyohara, Yutaka; Kato, Isao; Kubo, Michiaki; Tanizaki, Yumihiro; Iwamoto, Hiromitsu; Nakayama, Keizo; Abe, Isao; Fujishima, Masatoshi.

In: Alcoholism: Clinical and Experimental Research, Vol. 26, No. 7, 01.01.2002, p. 1010-1016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alcohol intake and future incidence of hypertension in a general Japanese population

T2 - The Hisayama study

AU - Ohmori, Susumu

AU - Kiyohara, Yutaka

AU - Kato, Isao

AU - Kubo, Michiaki

AU - Tanizaki, Yumihiro

AU - Iwamoto, Hiromitsu

AU - Nakayama, Keizo

AU - Abe, Isao

AU - Fujishima, Masatoshi

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Background: The question remains as to whether light to moderate alcohol intake is associated with an increased risk of hypertension. Methods: In 1978, a total of 1101 residents (433 men and 668 women) in a subrural community, Hisayama, in Japan, aged 40 years or more, with normal blood pressure, who were free from cardiovascular disease, were enrolled in a 10-year follow-up study. Inquiries regarding regular drinking were made in an interview based on a self-administered questionnaire. Results: During the follow-up, 101 men and 166 women developed hypertension (blood pressure ≥140/90 mm Hg or use of antihypertensive drugs). The age-adjusted incidence of hypertension among current male drinkers increased significantly even with a light intake of alcohol (<23 g of ethanol per day). In women, the incidence was also significantly higher in drinkers than in nondrinkers. In multivariate analysis, alcohol intake, in addition to age and body mass index, remained a significant independent risk factor for hypertension in men, but not in women. In men, all three categories of current drinking were found to be significant risk factors for the development of hypertension after adjustment for age and body mass index [relative risk (RR), 2.00; 95% confidence interval (CI), 1.07-3.76 for light drinking compared with nondrinking; RR, 2.60; 95% CI, 1.50-4.49 for moderate drinking (23-45 g per day); and RR, 2.24; 95% CI, 1.26-3.99 for heavy drinking (≥46 g/day)]. Conclusions: Our results suggest that alcohol intake, even light drinking, is a predictor of future hypertension among Japanese men.

AB - Background: The question remains as to whether light to moderate alcohol intake is associated with an increased risk of hypertension. Methods: In 1978, a total of 1101 residents (433 men and 668 women) in a subrural community, Hisayama, in Japan, aged 40 years or more, with normal blood pressure, who were free from cardiovascular disease, were enrolled in a 10-year follow-up study. Inquiries regarding regular drinking were made in an interview based on a self-administered questionnaire. Results: During the follow-up, 101 men and 166 women developed hypertension (blood pressure ≥140/90 mm Hg or use of antihypertensive drugs). The age-adjusted incidence of hypertension among current male drinkers increased significantly even with a light intake of alcohol (<23 g of ethanol per day). In women, the incidence was also significantly higher in drinkers than in nondrinkers. In multivariate analysis, alcohol intake, in addition to age and body mass index, remained a significant independent risk factor for hypertension in men, but not in women. In men, all three categories of current drinking were found to be significant risk factors for the development of hypertension after adjustment for age and body mass index [relative risk (RR), 2.00; 95% confidence interval (CI), 1.07-3.76 for light drinking compared with nondrinking; RR, 2.60; 95% CI, 1.50-4.49 for moderate drinking (23-45 g per day); and RR, 2.24; 95% CI, 1.26-3.99 for heavy drinking (≥46 g/day)]. Conclusions: Our results suggest that alcohol intake, even light drinking, is a predictor of future hypertension among Japanese men.

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