Abstract
Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. We prospectively examined this hypothesis in 1,133 nonhypertensive, nondiabetic Japanese subjects, aged 40-79 years. Alcohol drinkers were more frequent among men than women at baseline (57.7 vs. 8.2%). The age-adjusted incidence of hypertension significantly increased with the elevating baseline insulin levels in women (P = .003 for trend), but not in men. The age- and sex-adjusted insulin levels and insulin resistance index decreased with elevating alcohol intake, while fasting glucose levels remained unchanged, suggesting that alcohol improves insulin sensitivity. Among nondrinkers, the age-adjusted incidence of hypertension significantly increased with elevating insulin tertiles in both sexes (P = .048 and .002 for trend in men and women, respectively), but not among drinkers. Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. However, alcohol modified and reduced this relationship.
| Original language | English |
|---|---|
| Pages (from-to) | 863-869 |
| Number of pages | 7 |
| Journal | Journal of Clinical Epidemiology |
| Volume | 55 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 01-09-2002 |
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All Science Journal Classification (ASJC) codes
- Epidemiology
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Alcohol reduces insulin-hypertension relationship in a general population : The Hisayama study. / Arima, Hisatomi; Kiyohara, Yutaka; Kato, Isao; Tanizaki, Yumihiro; Kubo, Michiaki; Iwamoto, Hiromitsu; Tanaka, Keiichi; Abe, Isao; Fujishima, Masatoshi.
In: Journal of Clinical Epidemiology, Vol. 55, No. 9, 01.09.2002, p. 863-869.Research output: Contribution to journal › Article
TY - JOUR
T1 - Alcohol reduces insulin-hypertension relationship in a general population
T2 - The Hisayama study
AU - Arima, Hisatomi
AU - Kiyohara, Yutaka
AU - Kato, Isao
AU - Tanizaki, Yumihiro
AU - Kubo, Michiaki
AU - Iwamoto, Hiromitsu
AU - Tanaka, Keiichi
AU - Abe, Isao
AU - Fujishima, Masatoshi
PY - 2002/9/1
Y1 - 2002/9/1
N2 - Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. We prospectively examined this hypothesis in 1,133 nonhypertensive, nondiabetic Japanese subjects, aged 40-79 years. Alcohol drinkers were more frequent among men than women at baseline (57.7 vs. 8.2%). The age-adjusted incidence of hypertension significantly increased with the elevating baseline insulin levels in women (P = .003 for trend), but not in men. The age- and sex-adjusted insulin levels and insulin resistance index decreased with elevating alcohol intake, while fasting glucose levels remained unchanged, suggesting that alcohol improves insulin sensitivity. Among nondrinkers, the age-adjusted incidence of hypertension significantly increased with elevating insulin tertiles in both sexes (P = .048 and .002 for trend in men and women, respectively), but not among drinkers. Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. However, alcohol modified and reduced this relationship.
AB - Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. We prospectively examined this hypothesis in 1,133 nonhypertensive, nondiabetic Japanese subjects, aged 40-79 years. Alcohol drinkers were more frequent among men than women at baseline (57.7 vs. 8.2%). The age-adjusted incidence of hypertension significantly increased with the elevating baseline insulin levels in women (P = .003 for trend), but not in men. The age- and sex-adjusted insulin levels and insulin resistance index decreased with elevating alcohol intake, while fasting glucose levels remained unchanged, suggesting that alcohol improves insulin sensitivity. Among nondrinkers, the age-adjusted incidence of hypertension significantly increased with elevating insulin tertiles in both sexes (P = .048 and .002 for trend in men and women, respectively), but not among drinkers. Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. However, alcohol modified and reduced this relationship.
UR - http://www.scopus.com/inward/record.url?scp=0036709996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036709996&partnerID=8YFLogxK
U2 - 10.1016/S0895-4356(02)00441-9
DO - 10.1016/S0895-4356(02)00441-9
M3 - Article
C2 - 12393073
AN - SCOPUS:0036709996
VL - 55
SP - 863
EP - 869
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
SN - 0895-4356
IS - 9
ER -