Alcohol reduces insulin-hypertension relationship in a general population

The Hisayama study

Hisatomi Arima, Yutaka Kiyohara, Isao Kato, Yumihiro Tanizaki, Michiaki Kubo, Hiromitsu Iwamoto, Keiichi Tanaka, Isao Abe, Masatoshi Fujishima

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. We prospectively examined this hypothesis in 1,133 nonhypertensive, nondiabetic Japanese subjects, aged 40-79 years. Alcohol drinkers were more frequent among men than women at baseline (57.7 vs. 8.2%). The age-adjusted incidence of hypertension significantly increased with the elevating baseline insulin levels in women (P = .003 for trend), but not in men. The age- and sex-adjusted insulin levels and insulin resistance index decreased with elevating alcohol intake, while fasting glucose levels remained unchanged, suggesting that alcohol improves insulin sensitivity. Among nondrinkers, the age-adjusted incidence of hypertension significantly increased with elevating insulin tertiles in both sexes (P = .048 and .002 for trend in men and women, respectively), but not among drinkers. Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. However, alcohol modified and reduced this relationship.

Original languageEnglish
Pages (from-to)863-869
Number of pages7
JournalJournal of Clinical Epidemiology
Volume55
Issue number9
DOIs
Publication statusPublished - 01-09-2002

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Alcohols
Insulin Resistance
Insulin
Hypertension
Population
Incidence
Fasting
Glucose

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Arima, Hisatomi ; Kiyohara, Yutaka ; Kato, Isao ; Tanizaki, Yumihiro ; Kubo, Michiaki ; Iwamoto, Hiromitsu ; Tanaka, Keiichi ; Abe, Isao ; Fujishima, Masatoshi. / Alcohol reduces insulin-hypertension relationship in a general population : The Hisayama study. In: Journal of Clinical Epidemiology. 2002 ; Vol. 55, No. 9. pp. 863-869.
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Arima, H, Kiyohara, Y, Kato, I, Tanizaki, Y, Kubo, M, Iwamoto, H, Tanaka, K, Abe, I & Fujishima, M 2002, 'Alcohol reduces insulin-hypertension relationship in a general population: The Hisayama study', Journal of Clinical Epidemiology, vol. 55, no. 9, pp. 863-869. https://doi.org/10.1016/S0895-4356(02)00441-9

Alcohol reduces insulin-hypertension relationship in a general population : The Hisayama study. / Arima, Hisatomi; Kiyohara, Yutaka; Kato, Isao; Tanizaki, Yumihiro; Kubo, Michiaki; Iwamoto, Hiromitsu; Tanaka, Keiichi; Abe, Isao; Fujishima, Masatoshi.

In: Journal of Clinical Epidemiology, Vol. 55, No. 9, 01.09.2002, p. 863-869.

Research output: Contribution to journalArticle

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AU - Fujishima, Masatoshi

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