Allogeneic cryopreserved marrow transplantation in a patient with chronic myelogenous leukemia

Yoshiki Akatsuka, T. Takeshita, S. Tsuzuki, R. Suzuki, T. Sugihara, S. Minami, Y. Kodera

Research output: Contribution to journalArticle

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Abstract

A 45-year-old male with chronic myelogenous leukemia received cryopreserved allogeneic bone marrow from his HLA-identical sister. Bone marrow was harvested and cryopreserved prior to chemoradiotherapy since the donor had neurotic tendencies. The preconditioning regimen consisted of standard dosage of busulfan plus cyclophosphamide and total lymphoid irradiation (5Gy). A total of 3.1 x 10(7)/kg marrow mononuclear cells, containing 4.7 x 10(5) CD34+ cells/kg, and 8.0 x 10(6)/kg buffy coat cells collected from the donor at day 0 was infused. Marrow engraftment occurred by day 38 although hematological recovery was delayed and subsequent administration of GM-CSF, methylprednisolone and donor buffy coat cells were required. Mononuclear cells obtained from the patient's blood at day 28 had an inhibitory effect on CFU-GM formation of the donor's bone marrow mononuclear cells. We considered that this case suffered from a transient myelosuppression due to residual host cells after bone marrow transplantation.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume35
Issue number3
Publication statusPublished - 01-01-1994
Externally publishedYes

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Transplantation
Bone Marrow
Tissue Donors
Glycocalyx
Lymphatic Irradiation
Busulfan
Granulocyte-Macrophage Progenitor Cells
Methylprednisolone
Chemoradiotherapy
Granulocyte-Macrophage Colony-Stimulating Factor
Bone Marrow Transplantation
Bone Marrow Cells
Cyclophosphamide
Siblings

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Akatsuka, Y., Takeshita, T., Tsuzuki, S., Suzuki, R., Sugihara, T., Minami, S., & Kodera, Y. (1994). Allogeneic cryopreserved marrow transplantation in a patient with chronic myelogenous leukemia. [Rinshō ketsueki] The Japanese journal of clinical hematology, 35(3), 304-308.
Akatsuka, Yoshiki ; Takeshita, T. ; Tsuzuki, S. ; Suzuki, R. ; Sugihara, T. ; Minami, S. ; Kodera, Y. / Allogeneic cryopreserved marrow transplantation in a patient with chronic myelogenous leukemia. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 1994 ; Vol. 35, No. 3. pp. 304-308.
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Akatsuka, Y, Takeshita, T, Tsuzuki, S, Suzuki, R, Sugihara, T, Minami, S & Kodera, Y 1994, 'Allogeneic cryopreserved marrow transplantation in a patient with chronic myelogenous leukemia', [Rinshō ketsueki] The Japanese journal of clinical hematology, vol. 35, no. 3, pp. 304-308.

Allogeneic cryopreserved marrow transplantation in a patient with chronic myelogenous leukemia. / Akatsuka, Yoshiki; Takeshita, T.; Tsuzuki, S.; Suzuki, R.; Sugihara, T.; Minami, S.; Kodera, Y.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 35, No. 3, 01.01.1994, p. 304-308.

Research output: Contribution to journalArticle

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AU - Akatsuka, Yoshiki

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AU - Tsuzuki, S.

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AU - Minami, S.

AU - Kodera, Y.

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