Allotype-linked immune response genes: Roles in network control of the immune system

I. Nakashima, K. Isobe, T. Yoshida, T. Iwamoto, F. Nagase, Y. H. Zhang, M. Pu, T. Lwin

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Studies on allotype-linked immune response genes and related genes are overviewed with particular attention to our current results in unique models. Significance of actions of various immune response genes in relation to allelic polymorphism of molecules in the immune system is discussed. The molecules involve immunoglobulins, T cell receptors, major histocompatibility complex and a number of cell interaction molecules, many of which belong to the immunoglobulin superfamily. Differential roles of V-linked and C-linked immune response genes for network control of the immune system, preparing the V structure repertoire, controlling antigen presentation and modulating the effector mechanism, are suggested.

Original languageEnglish
Pages (from-to)121-139
Number of pages19
JournalExperimental and Clinical Immunogenetics
Volume8
Issue number3
Publication statusPublished - 01-12-1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

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  • Cite this

    Nakashima, I., Isobe, K., Yoshida, T., Iwamoto, T., Nagase, F., Zhang, Y. H., Pu, M., & Lwin, T. (1991). Allotype-linked immune response genes: Roles in network control of the immune system. Experimental and Clinical Immunogenetics, 8(3), 121-139.