TY - JOUR
T1 - Alpha-glucosidase inhibitor use is associated with decreased colorectal neoplasia risk in patients with type 2 diabetes mellitus receiving colonoscopy
T2 - A retrospective study
AU - Horibe, Yohei
AU - Adachi, Seiji
AU - Ohno, Tomohiko
AU - Goto, Naoe
AU - Okuno, Mitsuru
AU - Iwama, Midori
AU - Yamauchi, Osamu
AU - Kojima, Takao
AU - Saito, Koshiro
AU - Ibuka, Takashi
AU - Yasuda, Ichiro
AU - Araki, Hiroshi
AU - Moriwaki, Hisataka
AU - Shimizu, Masahito
N1 - Publisher Copyright:
© Horibe et al.
PY - 2017
Y1 - 2017
N2 - Purpose: The purpose of this study was to clarify the factors that influence the incidence of colorectal neoplasia in patients with type 2 diabetes mellitus (DM). Study Design and Setting: Among a total of 1176 patients who underwent total colonoscopy at our hospital, we retrospectively analyzed 168 patients with type 2 DM. Univariate and multivariate logistic regression analyses were then performed to identify the risk factors associated with colorectal neoplasia. Results: A multivariate analysis of these patients demonstrated that male gender (odds ratio [OR] = 4.04, 95% confidence interval [CI] = 1.67-10.37, p = 0.002), taking statins (OR = 4.59, 95% CI = 1.69-13.43, p = 0.003), taking alpha glucosidase inhibitor (a-GI) (OR = 0.35, 95% CI = 0.13-0.87, p = 0.023) and taking low-dose aspirin (LDA) (OR = 0.32, 95% CI = 0.10-0.95, p = 0.040) were independent factors associated with an increased (male gender and statins) or decreased (a-GI and LDA) risk of colorectal neoplasia. Conclusions: While male gender and taking statins are risk factors, taking a-GI as well as LDA may reduce the risk of colorectal neoplasia in patients with type2 DM.
AB - Purpose: The purpose of this study was to clarify the factors that influence the incidence of colorectal neoplasia in patients with type 2 diabetes mellitus (DM). Study Design and Setting: Among a total of 1176 patients who underwent total colonoscopy at our hospital, we retrospectively analyzed 168 patients with type 2 DM. Univariate and multivariate logistic regression analyses were then performed to identify the risk factors associated with colorectal neoplasia. Results: A multivariate analysis of these patients demonstrated that male gender (odds ratio [OR] = 4.04, 95% confidence interval [CI] = 1.67-10.37, p = 0.002), taking statins (OR = 4.59, 95% CI = 1.69-13.43, p = 0.003), taking alpha glucosidase inhibitor (a-GI) (OR = 0.35, 95% CI = 0.13-0.87, p = 0.023) and taking low-dose aspirin (LDA) (OR = 0.32, 95% CI = 0.10-0.95, p = 0.040) were independent factors associated with an increased (male gender and statins) or decreased (a-GI and LDA) risk of colorectal neoplasia. Conclusions: While male gender and taking statins are risk factors, taking a-GI as well as LDA may reduce the risk of colorectal neoplasia in patients with type2 DM.
KW - Colorectal neoplasia
KW - Risk factor
KW - Type 2 diabetes mellitus
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U2 - 10.18632/oncotarget.18416
DO - 10.18632/oncotarget.18416
M3 - Article
C2 - 29228657
AN - SCOPUS:85035006739
SN - 1949-2553
VL - 8
SP - 97862
EP - 97870
JO - Oncotarget
JF - Oncotarget
IS - 58
ER -