Alpha-glucosidase inhibitor use is associated with decreased colorectal neoplasia risk in patients with type 2 diabetes mellitus receiving colonoscopy: A retrospective study

Yohei Horibe, Seiji Adachi, Tomohiko Ohno, Naoe Goto, Mitsuru Okuno, Midori Iwama, Osamu Yamauchi, Takao Kojima, Koshiro Saito, Takashi Ibuka, Ichiro Yasuda, Hiroshi Araki, Hisataka Moriwaki, Masahito Shimizu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to clarify the factors that influence the incidence of colorectal neoplasia in patients with type 2 diabetes mellitus (DM). Study Design and Setting: Among a total of 1176 patients who underwent total colonoscopy at our hospital, we retrospectively analyzed 168 patients with type 2 DM. Univariate and multivariate logistic regression analyses were then performed to identify the risk factors associated with colorectal neoplasia. Results: A multivariate analysis of these patients demonstrated that male gender (odds ratio [OR] = 4.04, 95% confidence interval [CI] = 1.67-10.37, p = 0.002), taking statins (OR = 4.59, 95% CI = 1.69-13.43, p = 0.003), taking alpha glucosidase inhibitor (a-GI) (OR = 0.35, 95% CI = 0.13-0.87, p = 0.023) and taking low-dose aspirin (LDA) (OR = 0.32, 95% CI = 0.10-0.95, p = 0.040) were independent factors associated with an increased (male gender and statins) or decreased (a-GI and LDA) risk of colorectal neoplasia. Conclusions: While male gender and taking statins are risk factors, taking a-GI as well as LDA may reduce the risk of colorectal neoplasia in patients with type2 DM.

Original languageEnglish
Pages (from-to)97862-97870
Number of pages9
JournalOncotarget
Volume8
Issue number58
DOIs
Publication statusPublished - 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology

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