Alteration of Ammonia and Carnitine Levels in Short-Term Treatment with Pivalic Acid-Containing Prodrug

Tetsuya Ito, Naruji Sugiyama, Masanori Kobayashi, Kiyoshi Kidouchi, Tamiko Itoh, Osamu Uemura, Kohachiro Sugiyama, Hajime Togari

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We investigated the influence on mitochondrial functions in carnitine deficiency caused by short-term treatment of cefteram-pivoxil (CFTM-PI) which is one of pivaloyloxymethyl-esterified antibiotics in adult volunteers and diseased children. Administration of CFTM-PI caused hypocarnitinemia in all cases, and we observed a significant elevation of blood ammonia levels compared with those after its withdrawal in diseased children. A significant negative correlation was found between the levels of serum free carnitine and blood ammonia, and a positive correlation was observed between serum carnitine and blood glutamine levels in all adult samples and samples during administration in diseased children. Our data suggest that these antibiotic medications affect the mitochondrial function even in a short-term treatment and that l-carnitine supplementation would be necessary for patients treated with CFTM-PI.

Original languageEnglish
Pages (from-to)43-53
Number of pages11
JournalTohoku Journal of Experimental Medicine
Volume175
Issue number1
DOIs
Publication statusPublished - 01-01-1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Alteration of Ammonia and Carnitine Levels in Short-Term Treatment with Pivalic Acid-Containing Prodrug'. Together they form a unique fingerprint.

  • Cite this