Alteration of colonic mucin after ureterosigmoidostomy

Chikao Shimamoto, Ichiro Hirata, Yujiro Takao, Hiroya Takiuchi, Hiroshi Morikawa, Yoshihito Nakagawa, Ken Ichi Katsu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

PURPOSE: Patients undergoing urinary diversion by ureterosigmoidostomy after complete cystectomy for malignant bladder tumors show a high incidence of neoplasia at and near the site of anastomosis. We examined a risk factor for tumor occurrence in the area of anastomosis, alterations of mucus glycoproteins in the surrounding colonic mucosa. METHODS: Colonoscopy was performed in 37 patients who had undergone ureterosigmoidostomy. Biopsy specimens were obtained near the ureteral anastomosis and were stained with hematoxylin and eosin, high iron-diamine alcian blue (pH 2.5), and a fluorescent lectin conjugate (peanut agglutinin). RESULTS: At the anastomotic site colonoscopy showed protruding lesions in 26 of 37 patients (71 percent), all histologically representing inflammatory granulomas. The mucosa around the anastomosis was normal in endoscopic appearance; however, histologically, slight inflammatory cell infiltration, edema, and increased numbers of Paneth cells were observed. Alcian blue staining revealed an increase in mucosal sialomucin postoperatively compared with preoperatively. The proportion of peanut agglutinin-binding mucin, not observed in normal mucosa but seen in malignant or premalignant tissue, was increased. CONCLUSION: As postoperative interval increases, changes in properties of the 'background' mucosa become greater, which suggests an association with colonic carcinogenesis.

Original languageEnglish
Pages (from-to)526-531
Number of pages6
JournalDiseases of the Colon and Rectum
Volume43
Issue number4
DOIs
Publication statusPublished - 01-01-2000

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Mucins
Mucous Membrane
Peanut Agglutinin
Colonoscopy
Sialomucins
Paneth Cells
Alcian Blue
Urinary Diversion
Cystectomy
Hematoxylin
Eosine Yellowish-(YS)
Granuloma
Lectins
Urinary Bladder Neoplasms
Edema
Neoplasms
Carcinogenesis
Staining and Labeling
Biopsy
Incidence

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Shimamoto, C., Hirata, I., Takao, Y., Takiuchi, H., Morikawa, H., Nakagawa, Y., & Katsu, K. I. (2000). Alteration of colonic mucin after ureterosigmoidostomy. Diseases of the Colon and Rectum, 43(4), 526-531. https://doi.org/10.1007/BF02237199
Shimamoto, Chikao ; Hirata, Ichiro ; Takao, Yujiro ; Takiuchi, Hiroya ; Morikawa, Hiroshi ; Nakagawa, Yoshihito ; Katsu, Ken Ichi. / Alteration of colonic mucin after ureterosigmoidostomy. In: Diseases of the Colon and Rectum. 2000 ; Vol. 43, No. 4. pp. 526-531.
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Shimamoto, C, Hirata, I, Takao, Y, Takiuchi, H, Morikawa, H, Nakagawa, Y & Katsu, KI 2000, 'Alteration of colonic mucin after ureterosigmoidostomy', Diseases of the Colon and Rectum, vol. 43, no. 4, pp. 526-531. https://doi.org/10.1007/BF02237199

Alteration of colonic mucin after ureterosigmoidostomy. / Shimamoto, Chikao; Hirata, Ichiro; Takao, Yujiro; Takiuchi, Hiroya; Morikawa, Hiroshi; Nakagawa, Yoshihito; Katsu, Ken Ichi.

In: Diseases of the Colon and Rectum, Vol. 43, No. 4, 01.01.2000, p. 526-531.

Research output: Contribution to journalArticle

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AU - Shimamoto, Chikao

AU - Hirata, Ichiro

AU - Takao, Yujiro

AU - Takiuchi, Hiroya

AU - Morikawa, Hiroshi

AU - Nakagawa, Yoshihito

AU - Katsu, Ken Ichi

PY - 2000/1/1

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N2 - PURPOSE: Patients undergoing urinary diversion by ureterosigmoidostomy after complete cystectomy for malignant bladder tumors show a high incidence of neoplasia at and near the site of anastomosis. We examined a risk factor for tumor occurrence in the area of anastomosis, alterations of mucus glycoproteins in the surrounding colonic mucosa. METHODS: Colonoscopy was performed in 37 patients who had undergone ureterosigmoidostomy. Biopsy specimens were obtained near the ureteral anastomosis and were stained with hematoxylin and eosin, high iron-diamine alcian blue (pH 2.5), and a fluorescent lectin conjugate (peanut agglutinin). RESULTS: At the anastomotic site colonoscopy showed protruding lesions in 26 of 37 patients (71 percent), all histologically representing inflammatory granulomas. The mucosa around the anastomosis was normal in endoscopic appearance; however, histologically, slight inflammatory cell infiltration, edema, and increased numbers of Paneth cells were observed. Alcian blue staining revealed an increase in mucosal sialomucin postoperatively compared with preoperatively. The proportion of peanut agglutinin-binding mucin, not observed in normal mucosa but seen in malignant or premalignant tissue, was increased. CONCLUSION: As postoperative interval increases, changes in properties of the 'background' mucosa become greater, which suggests an association with colonic carcinogenesis.

AB - PURPOSE: Patients undergoing urinary diversion by ureterosigmoidostomy after complete cystectomy for malignant bladder tumors show a high incidence of neoplasia at and near the site of anastomosis. We examined a risk factor for tumor occurrence in the area of anastomosis, alterations of mucus glycoproteins in the surrounding colonic mucosa. METHODS: Colonoscopy was performed in 37 patients who had undergone ureterosigmoidostomy. Biopsy specimens were obtained near the ureteral anastomosis and were stained with hematoxylin and eosin, high iron-diamine alcian blue (pH 2.5), and a fluorescent lectin conjugate (peanut agglutinin). RESULTS: At the anastomotic site colonoscopy showed protruding lesions in 26 of 37 patients (71 percent), all histologically representing inflammatory granulomas. The mucosa around the anastomosis was normal in endoscopic appearance; however, histologically, slight inflammatory cell infiltration, edema, and increased numbers of Paneth cells were observed. Alcian blue staining revealed an increase in mucosal sialomucin postoperatively compared with preoperatively. The proportion of peanut agglutinin-binding mucin, not observed in normal mucosa but seen in malignant or premalignant tissue, was increased. CONCLUSION: As postoperative interval increases, changes in properties of the 'background' mucosa become greater, which suggests an association with colonic carcinogenesis.

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Shimamoto C, Hirata I, Takao Y, Takiuchi H, Morikawa H, Nakagawa Y et al. Alteration of colonic mucin after ureterosigmoidostomy. Diseases of the Colon and Rectum. 2000 Jan 1;43(4):526-531. https://doi.org/10.1007/BF02237199